ATG9A

ATG9A
Identifiers
Aliases	ATG9A , APG9L1, MGD3208, mATG9, autophagy related 9A
External IDs	OMIM: 612204; MGI: 2138446; HomoloGene: 34495; GeneCards: ATG9A; OMA:ATG9A - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q35 Start 219,219,380 bp [1] End 219,229,717 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C4 Start 75,157,504 bp [2] End 75,168,840 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue apex of heart muscle of thigh left testis right testis blood stromal cell of endometrium left ventricle prefrontal cortex Top expressed in muscle of thigh testicle skeletal muscle tissue quadriceps femoris muscle spermatid granulocyte striatum of neuraxis superior frontal gyrus primary visual cortex cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane recycling endosome endosome late endosome Golgi apparatus endoplasmic reticulum membrane membrane late endosome membrane phagophore assembly site trans-Golgi network autophagosome membrane endoplasmic reticulum cytoplasmic vesicle autophagosome intracellular membrane-bounded organelle cytoplasmic vesicle membrane Biological process protein localization to phagophore assembly site autophagosome assembly autophagy autophagy of mitochondrion late nucleophagy protein transport response to nutrient levels transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79065 245860 Ensembl ENSG00000198925 ENSMUSG00000033124 UniProt Q7Z3C6 Q68FE2 RefSeq (mRNA) NM_001077198 NM_024085 NM_001003917 NM_001288612 NM_001288613 RefSeq (protein) NP_001070666 NP_076990 NP_001070666.1 NP_076990.4 NP_001003917 NP_001275541 NP_001275542 NP_001395154 NP_001395156 NP_001395158 NP_001395159 NP_001395160 Location (UCSC) Chr 2: 219.22 – 219.23 Mb Chr 1: 75.16 – 75.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Autophagy-related protein 9A is a protein that in humans is encoded by the ATG9A gene. ^[5]

Functional studies indicate that ATG9A plays a role in autophagy. ^{[6] [7]} and other non-autophagy membrane remodeling processes such as plasma membrane repair. ^[8] Enzymatically, it is a lipid scramblase. ^{[6] [7]} ATG9A interacts with IQGAP1 and the ESCRT machinery in membrane remodeling. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000198925 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033124 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae)".
6. Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, et al. (December 2020). "Structure, lipid scrambling activity and role in autophagosome formation of ATG9A". Nature Structural & Molecular Biology. 27 (12): 1194–1201. doi:10.1038/s41594-020-00520-2. PMC   7718406 . PMID   33106659.
7. Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, et al. (December 2020). "Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion". Nature Structural & Molecular Biology. 27 (12): 1185–1193. doi:10.1038/s41594-020-00518-w. PMID   33106658. S2CID   225081989.
8. Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GP, et al. (July 2021). "ATG9A protects the plasma membrane from programmed and incidental permeabilization". Nature Cell Biology. 23 (8): 846–858. doi:10.1038/s41556-021-00706-w. ISSN   1465-7392. PMC   8276549 . PMID   34257406.

Further reading

• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Yamada T, Carson AR, Caniggia I, Umebayashi K, Yoshimori T, Nakabayashi K, Scherer SW (May 2005). "Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast". The Journal of Biological Chemistry. 280 (18): 18283–90. doi: 10.1074/jbc.M413957200 . PMID   15755735.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• Human ATG9A genome location and ATG9A gene details page in the UCSC Genome Browser .