ATG9A

Last updated
ATG9A
Identifiers
Aliases ATG9A , APG9L1, MGD3208, mATG9, autophagy related 9A
External IDs OMIM: 612204 MGI: 2138446 HomoloGene: 34495 GeneCards: ATG9A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077198
NM_024085

NM_001003917
NM_001288612
NM_001288613

RefSeq (protein)

NP_001070666
NP_076990
NP_001070666.1
NP_076990.4

Location (UCSC) Chr 2: 219.22 – 219.23 Mb Chr 1: 75.16 – 75.17 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Autophagy-related protein 9A is a protein that in humans is encoded by the ATG9A gene. [5]

Contents

Functional studies indicate that ATG9A plays a role in autophagy. [6] [7] and other non-autophagy membrane remodeling processes such as plasma membrane repair. [8] Enzymatically, it is a lipid scramblase. [6] [7] ATG9A interacts with IQGAP1 and the ESCRT machinery in membrane remodeling. [8]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198925 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033124 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae)".
  6. 1 2 Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, et al. (December 2020). "Structure, lipid scrambling activity and role in autophagosome formation of ATG9A". Nature Structural & Molecular Biology. 27 (12): 1194–1201. doi:10.1038/s41594-020-00520-2. PMC   7718406 . PMID   33106659.
  7. 1 2 Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, et al. (December 2020). "Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion". Nature Structural & Molecular Biology. 27 (12): 1185–1193. doi:10.1038/s41594-020-00518-w. PMID   33106658. S2CID   225081989.
  8. 1 2 Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GP, et al. (July 2021). "ATG9A protects the plasma membrane from programmed and incidental permeabilization". Nature Cell Biology. 23 (8): 846–858. doi:10.1038/s41556-021-00706-w. ISSN   1465-7392. PMC   8276549 . PMID   34257406.

Further reading