ATPase ASNA1

ASNA1
Identifiers
Aliases	ASNA1 , ARSA-I, ARSA1, ASNA-I, GET3, TRC40, hASNA-I, arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
External IDs	OMIM: 601913; MGI: 1928379; HomoloGene: 31513; GeneCards: ASNA1; OMA:ASNA1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.13 Start 12,737,139 bp [1] End 12,748,323 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 C3 Start 85,744,560 bp [2] End 85,751,910 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte stromal cell of endometrium prefrontal cortex right adrenal gland apex of heart right adrenal cortex right frontal lobe left adrenal gland right testis islet of Langerhans Top expressed in choroid plexus of fourth ventricle yolk sac epiblast dentate gyrus of hippocampal formation granule cell neural layer of retina superior frontal gyrus primary visual cortex central gray substance of midbrain perirhinal cortex medulla oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity protein binding hydrolase activity ATP binding arsenite transmembrane transporter activity metal ion binding transporter activity ATPase-coupled transmembrane transporter activity Cellular component cytoplasm nucleolus extracellular exosome endoplasmic reticulum membrane nucleus endoplasmic reticulum GET complex Biological process IRE1-mediated unfolded protein response inorganic anion transport transport posttranslational protein targeting to endoplasmic reticulum membrane arsenite transport protein insertion into ER membrane tail-anchored membrane protein insertion into ER membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 439 56495 Ensembl ENSG00000198356 ENSMUSG00000052456 UniProt O43681 O54984 RefSeq (mRNA) NM_004317 NM_019652 NM_001357202 NM_001357203 RefSeq (protein) NP_004308 NP_001358417 NP_001358418 NP_062626 NP_001344131 NP_001344132 Location (UCSC) Chr 19: 12.74 – 12.75 Mb Chr 8: 85.74 – 85.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATPase ASNA1 also known as arsenical pump-driving ATPase and arsenite-stimulated ATPase is an enzyme that in humans is encoded by the ASNA1 gene. ^{[5] [6]}

Function

ASNA1 is the human homolog of the bacterial arsA gene. In E. coli , arsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials. ^[6]

Interactions

ASNA1 is found to interact with FAM71D according to STRING ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000198356 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052456 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kurdi-Haidar B, Aebi S, Heath D, Enns RE, Naredi P, Hom DK, Howell SB (Feb 1997). "Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter". Genomics. 36 (3): 486–91. doi:10.1006/geno.1996.0494. PMID   8884272.
6. "Entrez Gene: ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)".
7. "STRING 10". Archived from the original on 2013-05-15. Retrieved 2015-05-11.

External links

• Human ASNA1 genome location and ASNA1 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Kurdi-Haidar B, Heath D, Aebi S, Howell SB (1998). "Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I)". J. Biol. Chem. 273 (35): 22173–6. doi: 10.1074/jbc.273.35.22173 . PMID   9712828.
• Kurdi-Haidar B, Hom DK, Flittner DE, et al. (1998). "Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I)". J. Cell. Biochem. 71 (1): 1–10. doi:10.1002/(SICI)1097-4644(19981001)71:1<1::AID-JCB1>3.0.CO;2-#. PMID   9736449. S2CID   196597195.
• Kurdi-Haidar B, Heath D, Lennon G, Howell SB (2000). "Chromosomal localization and genomic structure of the human arsenite-stimulated ATPase (hASNA-I)". Somat. Cell Mol. Genet. 24 (5): 307–11. doi:10.1023/B:SCAM.0000007134.16744.8b. PMID   10696239. S2CID   11936516.
• Kao G, Nordenson C, Still M, et al. (2007). "ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells". Cell. 128 (3): 577–87. doi: 10.1016/j.cell.2006.12.031 . PMID   17289575. S2CID   2120123.
• Stefanovic S, Hegde RS (2007). "Identification of a targeting factor for posttranslational membrane protein insertion into the ER". Cell. 128 (6): 1147–59. doi: 10.1016/j.cell.2007.01.036 . PMID   17382883. S2CID   16802797.