ATRAID

ATRAID
Identifiers
Aliases	ATRAID , APR--3, APR-3, APR3, C2orf28, PRO240, p18, HSPC013, all-trans retinoic acid induced differentiation factor
External IDs	MGI: 1918918; HomoloGene: 15412; GeneCards: ATRAID; OMA:ATRAID - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.3 Start 27,212,041 bp [1] End 27,217,178 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B1 Start 31,205,656 bp [2] End 31,211,967 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell corpus epididymis right uterine tube apex of heart left ovary right ovary right auricle of heart right testis left lobe of thyroid gland right lobe of thyroid gland Top expressed in right kidney optic nerve arcuate nucleus umbilical cord median eminence islet of Langerhans vestibular sensory epithelium human kidney yolk sac white adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component perinuclear region of cytoplasm integral component of membrane lysosomal membrane plasma membrane nuclear envelope membrane nucleus Biological process regulation of gene expression negative regulation of osteoblast proliferation cell differentiation positive regulation of osteoblast differentiation positive regulation of bone mineralization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51374 381629 Ensembl ENSG00000138085 ENSMUSG00000013622 UniProt Q6UW56 Q6PGD0 RefSeq (mRNA) NM_080592 NM_001170795 NM_016085 NM_027855 NM_212470 RefSeq (protein) NP_001164266 NP_057169 NP_082131 NP_997635 Location (UCSC) Chr 2: 27.21 – 27.22 Mb Chr 5: 31.21 – 31.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Apoptosis-related protein 3 is a protein that in humans is encoded by the ATRAID gene. ^{[5] [6] [7]}

This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138085 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000013622 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
6. Zhu F, Yan W, Zhao ZL, Chai YB, Lu F, Wang Q, Peng WD, Yang AG, Wang CJ (Nov 2000). "Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes". BioTechniques. 29 (2): 310–3. doi: 10.2144/00292st06 . PMID   10948432.
7. "Entrez Gene: C2orf28 chromosome 2 open reading frame 28".

External links

• Human ATRAID genome location and ATRAID gene details page in the UCSC Genome Browser .

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Yang G, Yu F, Fu H, et al. (2007). "Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB". Mol. Cell. Biochem. 302 (1–2): 187–94. doi:10.1007/s11010-007-9440-7. PMID   17387583. S2CID   1525070.
• Yu F, Yang G, Zhao Z, et al. (2007). "Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1". Biochem. Biophys. Res. Commun. 358 (4): 1041–6. doi:10.1016/j.bbrc.2007.05.049. PMID   17524364.