AZI2

AZI2
Identifiers
Aliases	AZI2 , AZ2, NAP1, TILP, 5-azacytidine induced 2
External IDs	OMIM: 609916; MGI: 1351332; HomoloGene: 8443; GeneCards: AZI2; OMA:AZI2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p24.1 Start 28,315,003 bp [1] End 28,349,050 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F3 Start 118,040,499 bp [2] End 118,069,794 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium monocyte mucosa of paranasal sinus Achilles tendon buccal mucosa cell gastric mucosa right lung lower lobe of lung ganglionic eminence ventricular zone Top expressed in neural layer of retina spermatid genital tubercle tail of embryo spermatocyte ventricular zone dentate gyrus of hippocampal formation granule cell parotid gland atrioventricular valve seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm Biological process interleukin-6 production dendritic cell differentiation cytokine production tumor necrosis factor production interferon-alpha production I-kappaB kinase/NF-kappaB signaling T cell activation dendritic cell proliferation mitotic cell cycle viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64343 27215 Ensembl ENSG00000163512 ENSMUSG00000039285 UniProt Q9H6S1 Q9QYP6 RefSeq (mRNA) NM_001134432 NM_001134433 NM_001271650 NM_022461 NM_203326 NM_001048146 NM_001286507 NM_001286508 NM_013727 RefSeq (protein) NP_001127904 NP_001127905 NP_001258579 NP_071906 NP_001041611 NP_001273436 NP_001273437 NP_038755 Location (UCSC) Chr 3: 28.32 – 28.35 Mb Chr 9: 118.04 – 118.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

5-azacytidine-induced protein 2 is a protein that in humans is encoded by the AZI2 gene. ^{[5] [6]}

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003).[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000163512 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039285 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID   10580148.
6. "Entrez Gene: AZI2 5-azacytidine induced 2".

External links

• Human AZI2 genome location and AZI2 gene details page in the UCSC Genome Browser .

Further reading

• Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M (2007). "Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA". J. Immunol. 179 (10): 6867–72. doi: 10.4049/jimmunol.179.10.6867 . PMID   17982077.
• Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, et al. (2007). "NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction". J. Immunol. 177 (12): 8676–83. doi: 10.4049/jimmunol.177.12.8676 . PMID   17142768.
• Sasai M, Oshiumi H, Matsumoto M, Inoue N, Fujita F, Nakanishi M, et al. (2005). "Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation". J. Immunol. 174 (1): 27–30. doi: 10.4049/jimmunol.174.1.27 . PMID   15611223.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, et al. (2003). "Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling". Mol. Cell. Biol. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC   207563 . PMID   14560022.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.