AZI2

AZI2
Identifiers
Aliases	AZI2 , AZ2, NAP1, TILP, 5-azacytidine induced 2
External IDs	OMIM: 609916 MGI: 1351332 HomoloGene: 8443 GeneCards: AZI2
Gene location (Human)
Chr.	Chromosome 3 (human)
End	28,349,050 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	118,069,794 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; monocyte; ; Achilles tendon; ; gastric mucosa; ; right lung; ; lower lobe of lung; ; ganglionic eminence; ; anterior pituitary; ; canal of the cervix; ; upper lobe of left lung;
	Top expressed in
	spermatid; ; spermatocyte; ; parotid gland; ; atrioventricular valve; ; seminal vesicula; ; colon; ; left colon; ; duodenum; ; right ventricle; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	cytoplasm ;
Biological process	interleukin-6 production ; dendritic cell differentiation ; cytokine production ; tumor necrosis factor production ; interferon-alpha production ; I-kappaB kinase/NF-kappaB signaling ; T cell activation ; dendritic cell proliferation ; mitotic cell cycle ; viral process ;
	Sources:Amigo / QuickGO
Orthologs
	64343
	27215
	ENSG00000163512
	ENSMUSG00000039285
	Q9H6S1
	Q9QYP6
	NM_001134432 ; NM_001134433 ; NM_001271650 ; NM_022461 ; NM_203326 Contents References ; External links ; Further reading ;
	NM_001048146 ; NM_001286507 ; NM_001286508 ; NM_013727
	NP_001127904 ; NP_001127905 ; NP_001258579 ; NP_071906
	NP_001041611 ; NP_001273436 ; NP_001273437 ; NP_038755
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 10, 2024

5-azacytidine-induced protein 2 is a protein that in humans is encoded by the AZI2 gene.^[5]^[6]

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003).[supplied by OMIM]^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163512 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039285 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.
1 2 "Entrez Gene: AZI2 5-azacytidine induced 2".

External links

Human AZI2 genome location and AZI2 gene details page in the UCSC Genome Browser .

Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M (2007). "Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA". J. Immunol. 179 (10): 6867–72. doi: 10.4049/jimmunol.179.10.6867 . PMID 17982077.
Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, et al. (2007). "NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction". J. Immunol. 177 (12): 8676–83. doi: 10.4049/jimmunol.177.12.8676 . PMID 17142768.
Sasai M, Oshiumi H, Matsumoto M, Inoue N, Fujita F, Nakanishi M, et al. (2005). "Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation". J. Immunol. 174 (1): 27–30. doi: 10.4049/jimmunol.174.1.27 . PMID 15611223.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Bouwmeester T, Bauch A, Ruffner H, Angrand P, Bergamini G, Croughton K, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, et al. (2003). "Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling". Mol. Cell. Biol. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC 207563 . PMID 14560022.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163512 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039285 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10580148-5] Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene. 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.

[entrez-6] 1 2 "Entrez Gene: AZI2 5-azacytidine induced 2".

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AZI2

Contents

Related Research Articles

References

External links

Further reading