AZIN1

AZIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZGZ
Identifiers
Aliases	AZIN1 , AZI, AZIA1, OAZI, OAZIN, ODC1L, antizyme inhibitor 1, AZI1
External IDs	OMIM: 607909 MGI: 1859169 HomoloGene: 22933 GeneCards: AZIN1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	102,893,864 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	38,519,510 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; ganglionic eminence; ; placenta; ; bone marrow cells; ; jejunal mucosa; ; body of pancreas; ; caput epididymis; ; parotid gland; ; germinal epithelium; ; sperm;
	Top expressed in
	atrioventricular valve; ; barrel cortex; ; spermatocyte; ; lacrimal gland; ; atrium; ; spermatid; ; salivary gland; ; parotid gland; ; cingulate gyrus; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ornithine decarboxylase activator activity ; protein binding ; catalytic activity ; ornithine decarboxylase activity ;
Cellular component	cytosol ; nucleus ; cytoplasm ;
Biological process	polyamine biosynthetic process ; positive regulation of polyamine transmembrane transport ; regulation of cellular amino acid metabolic process ; putrescine biosynthetic process from ornithine ; positive regulation of catalytic activity ; negative regulation of protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	51582
	54375
	ENSG00000155096
	ENSMUSG00000037458
	O14977
	O35484
NM_001301668 ; NM_015878 ; NM_148174 ; NM_001363010 ; NM_001363011 ;
	NM_001363012 ; NM_001363013 ; NM_001363014 ; NM_001363024 ; NM_001363083 Contents References ; External links ; Further reading ;
	NM_001102458 ; NM_001301688 ; NM_018745
NP_001288597 ; NP_056962 ; NP_680479 ; NP_001349939 ; NP_001349940 ;
	NP_001349941 ; NP_001349942 ; NP_001349943 ; NP_001349953 ; NP_001350012
	NP_001095928 ; NP_001288617 ; NP_061215
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.^[5]^[6]^[7]

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.^[7]

Related Research Articles

<span class="mw-page-title-main">Ornithine decarboxylase</span>

The enzyme ornithine decarboxylase catalyzes the decarboxylation of ornithine to form putrescine. This reaction is the committed step in polyamine synthesis. In humans, this protein has 461 amino acids and forms a homodimer.

In molecular biology, Ornithine decarboxylase antizyme (ODC-AZ) is an ornithine decarboxylase inhibitor. It binds to, and destabilises, ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. ODC is then rapidly degraded. It was first characterized in 1981. The expression of ODC-AZ requires programmed, ribosomal frameshifting which is modulated according to the cellular concentration of polyamines. High levels of polyamines induce a +1 ribosomal frameshift in the translation of mRNA for the antizyme leading to the expression of a full-length protein. At least two forms of ODC-AZ exist in mammals and the protein has been found in Drosophila as well as in Saccharomyces yeast.

Ornithine decarboxylase is an enzyme that in humans is encoded by the ODC1 gene.

Plasminogen activator inhibitor 1 RNA-binding protein (serbp1) is a protein that in humans is encoded by the SERBP1 gene.

Ornithine decarboxylase antizyme is an enzyme that in humans is encoded by the OAZ1 gene.

Zinc finger protein 281 is a protein that in humans is encoded by the ZNF281 gene.

Protein FAM107A is a protein that in humans is encoded by the FAM107A gene.

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.

BAI1-associated protein 3 is a protein that in humans is encoded by the BAIAP3 gene.

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene.

Mitochondrial fission regulator 1 like is a protein that in humans is encoded by the MTFR1L gene.

Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene. In contrast to initial suggestions, Antizyme inhibitor 2 does not act as arginine decarboxylase (ADC) in mammalian cells

Transmembrane and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the TMCO1 gene.

E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene. It is a member of the MARCH family of E3 ligases, and plays an important role in the turnover of membrane proteins. MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial infections.

Forkhead box protein J2 is a protein that in humans is encoded by the FOXJ2 gene.

SEC14-like protein 1 is a protein that in humans is encoded by the SEC14L1 gene.

Ornithine decarboxylase antizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene.

Caspase activity and apoptosis inhibitor 1 is a protein that in humans is encoded by the CAAP1 gene.

Myotubularin related protein 14 also known as MTMR14 is a protein which in humans is encoded by the MTMR14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155096 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037458 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S (Nov 1997). "Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor". Biochim Biophys Acta. 1353 (3): 209–16. doi:10.1016/s0167-4781(97)00106-1. PMID 9349715.
↑ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
1 2 "Entrez Gene: AZIN1 antizyme inhibitor 1".

External links

Human AZIN1 genome location and AZIN1 gene details page in the UCSC Genome Browser .

Murakami Y, Matsufuji S, Hayashi S, et al. (2000). "Degradation of ornithine decarboxylase by the 26S proteasome". Biochem. Biophys. Res. Commun. 267 (1): 1–6. doi:10.1006/bbrc.1999.1706. PMID 10623564.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155096 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037458 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9349715-5] Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S (Nov 1997). "Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor". Biochim Biophys Acta. 1353 (3): 209–16. doi:10.1016/s0167-4781(97)00106-1. PMID 9349715.

[pmid9110174-6] Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.

[entrez-7] 1 2 "Entrez Gene: AZIN1 antizyme inhibitor 1".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

AZIN1

Contents

Related Research Articles

References

External links

Further reading