AZIN2

Last updated
AZIN2
Identifiers
Aliases AZIN2 , ADC, AZI2, ODC-p, ODC1L, ODCp, AZIB1, antizyme inhibitor 2
External IDs OMIM: 608353 MGI: 2442093 HomoloGene: 62172 GeneCards: AZIN2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301841
NM_172875

RefSeq (protein)

NP_001288770
NP_766463

Location (UCSC) Chr 1: 33.08 – 33.12 Mb Chr 4: 128.82 – 128.86 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene. [5] [6] [7] In contrast to initial suggestions, [5] Antizyme inhibitor 2 does not act as arginine decarboxylase (ADC) in mammalian cells [8] [9]

Related Research Articles

Ornithine decarboxylase

The enzyme ornithine decarboxylase catalyzes the decarboxylation of ornithine to form putrescine. This reaction is the committed step in polyamine synthesis. In humans, this protein has 461 amino acids and forms a homodimer.

Arginase Manganese-containing enzyme

Arginase (EC 3.5.3.1, arginine amidinase, canavanase, L-arginase, arginine transamidinase) is a manganese-containing enzyme. The reaction catalyzed by this enzyme is: arginine + H2O → ornithine + urea. It is the final enzyme of the urea cycle. It is ubiquitous to all domains of life.

Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It is found as a polycation at physiological pH. Spermine is associated with nucleic acids and is thought to stabilize helical structure, particularly in viruses.

<i>N</i>-Acetylglutamate synthase

N-Acetylglutamate synthase (NAGS) is an enzyme that catalyses the production of N-acetylglutamate (NAG) from glutamate and acetyl-CoA.

Complement component 1s

Complement component 1s is a protein involved in the complement system. C1s is part of the C1 complex. In humans, it is encoded by the C1S gene.

Complement factor B

Complement factor B is a protein that in humans is encoded by the CFB gene.

Malonyl-CoA decarboxylase

Malonyl-CoA decarboxylase, is found in bacteria and humans and has important roles in regulating fatty acid metabolism and food intake, and it is an attractive target for drug discovery. It is an enzyme associated with Malonyl-CoA decarboxylase deficiency. In humans, it is encoded by the MLYCD gene.

Ornithine decarboxylase antizyme

In molecular biology, Ornithine decarboxylase antizyme (ODC-AZ) is an ornithine decarboxylase inhibitor. It binds to, and destabilises, ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. ODC is then rapidly degraded. It was first characterized in 1981. The expression of ODC-AZ requires programmed, ribosomal frameshifting which is modulated according to the cellular concentration of polyamines. High levels of polyamines induce a +1 ribosomal frameshift in the translation of mRNA for the antizyme leading to the expression of a full-length protein. At least two forms of ODC-AZ exist in mammals and the protein has been found in Drosophila as well as in Saccharomyces yeast.

SOD3

Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene.

ODC1

Ornithine decarboxylase is an enzyme that in humans is encoded by the ODC1 gene.

Diaminopimelate decarboxylase

The enzyme diaminopimelate decarboxylase (EC 4.1.1.20) catalyzes the cleavage of carbon-carbon bonds in meso 2,6 diaminoheptanedioate to produce CO2 and L-lysine, the essential amino acid. It employs the cofactor pyridoxal phosphate, also known as PLP, which participates in numerous enzymatic transamination, decarboxylation and deamination reactions.

ZNF148 Gene of the species Homo sapiens

Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene.

OAZ1 Protein-coding gene in the species Homo sapiens

Ornithine decarboxylase antizyme is an enzyme that in humans is encoded by the OAZ1 gene.

SENP1

Sentrin-specific protease 1 is an enzyme that in humans is encoded by the SENP1 gene.

PRMT2 Protein-coding gene in the species Homo sapiens

Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.

CPD (gene)

Carboxypeptidase D is an enzyme that in humans is encoded by the CPD gene.

ADAM23 Protein-coding gene in the species Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 23 is a non-catalytic protein that in humans is encoded by the ADAM23 gene. It is a member of the ADAM family of extracellular matrix metalloproteinases.

AZIN1

Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.

OAZ2

Ornithine decarboxylase antizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene.

Y+L amino acid transporter 2

Y+L amino acid transporter 2, also known as cationic amino acid transporter, y+ system, is a protein that in humans is encoded by the SLC7A6 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000142920 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028789 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Pitkänen LT, Heiskala M, Andersson LC (October 2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochemical and Biophysical Research Communications. 287 (5): 1051–1057. doi:10.1006/bbrc.2001.5703. PMID   11587527.
  6. Zhu MY, Iyo A, Piletz JE, Regunathan S (January 2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochimica et Biophysica Acta (BBA) - General Subjects. 1670 (2): 156–164. doi:10.1016/j.bbagen.2003.11.006. PMC   3118518 . PMID   14738999.
  7. "Entrez Gene: ADC arginine decarboxylase".
  8. Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (January 2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase" (PDF). The Biochemical Journal. 409 (1): 187–192. doi:10.1042/BJ20071004. PMID   17900240.
  9. López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (October 2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". The Journal of Biological Chemistry. 281 (41): 30896–30906. doi: 10.1074/jbc.M602840200 . PMID   16916800.

Further reading