Author | Adam Rutherford |
---|---|
Country | United Kingdom |
Language | English |
Subject | Genetics |
Genre | Popular science |
Publisher | Weidenfeld & Nicolson (UK) The Experiment (US) |
Publication date | 8 September 2016 (UK) 3 October 2017 (US) |
Media type | Print (hardcover) |
Pages | 432 (UK) 416 (US) |
Awards |
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ISBN | 978-0297609377 (UK) 978-1615194049 (US) |
A Brief History of Everyone Who Ever Lived: The Stories in Our Genes (published in the United States as A Brief History of Everyone Who Ever Lived: The Human Story Retold Through Our Genes) is a popular science book by British geneticist, author and broadcaster Adam Rutherford. It was first published in 2016 in the United Kingdom by Weidenfeld & Nicolson. An updated edition [lower-alpha 1] was published in the United States in 2017, with a different subtitle, by The Experiment. [1] The book is about human genetics and what it reveals about human identity and their history.
A Brief History of Everyone Who Ever Lived won gold at the 2017 Foreword INDIE Book Awards for Science, [2] and won the 2018 Thomas Bonner Book Prize. [3] The book was also a 2017 National Book Critics Circle Award non-fiction finalist, [4] featured on the 2017 Wellcome Book Prize longlist, [5] and appeared on National Geographic's top 12 books from 2017. [6]
[*] 2017 US edition
A Brief History of Everyone Who Ever Lived explains the Out of Africa hypothesis that Homo sapiens originated in Africa about 200,000 years ago. They began slowly migrating to Europe around 100,000 years ago, where they encountered Neanderthals. DNA extracted from Neanderthal remains and compared to contemporary human DNA showed that Homo sapiens mated with Homo neanderthalensis. Today, about 2% of the sequence in European genomes is of Neanderthal origin. The book also investigates the lineage of European kings. DNA has enabled geneticists to construct their family trees going back to Charlemagne in the 8th century. Rutherford shows that family trees are not neat and tidy, but tangled webs. They often collapse in on themselves as a result of inbreeding. King Charles II's family tree was particularly bad as a result of incest in the family. Their rational for this practice was to preserve their "royal blood", and this often had an adverse effect on their health; Charles himself was disabled, epileptic and mentally unstable.
The book discusses the genes responsible for some human traits, including red hair, earwax and lactose intolerance/lactase persistence. Racial classification is shown to be a scientifically invalid concept. The genome encodes a huge number of characteristics that differ from person to person, which far outnumber the physical differences between black and white people. Rutherford concludes that genetics cannot be used to define race. Francis Galton and his contribution to the development of eugenics is also examined. The Human Genome Project revealed that humans only have about 20,000 genes, far fewer than scientists expected, and ended up posing more questions than it answered. The project also highlighted the limits of genetics and that it is no panacea for diseases. Rutherford criticises the popular press for their inaccurate reporting on genetics, and companies conducting DNA ancestry tests that produce impossibly accurate results. He says these companies and the press often overlook the fact that genetics is not an exact science – it is probabilistic.
In a review in The Guardian , Colin Grant described A Brief History of Everyone Who Ever Lived as an "effervescent work, brimming with tales and confounding ideas". [7] He called the author "an enthusiastic guide" who disentangles the maze of collapsed family trees and inbreeding. Grant felt that he was "especially illuminating" on the ill-defined notion of race, and "how it both does and doesn't exist". He said that Rutherford aims high: the rewriting human history, but called him "a commendable historian ... who is determined to illuminate the commonality of Homo sapiens". [7]
Robin McKie described Rutherford's exposition of the Human Genome Project as "elegant". Writing in another review of the book in The Guardian, McKie noted how the author is careful to bring the project's "dreams of a medical revolution" down to earth, emphasising that its "greatest achievement ... was working out exactly how little we knew." [8] McKie praised Rutherford for highlighting modern genetics' limitations, that it is better at describing humans as a species than as individuals. He called the book "a polished, thoroughly entertaining history of Homo sapiens", adding that it is "popular science writing at its best". [8]
In a review in The New York Times , Misha Angrist described A Brief History of Everyone Who Ever Lived as "nothing less than a tour de force". [1] Despite the book's ambitious tile, he felt that Rutherford "deliver[s] on its great promise". Angrist complimented the author on his "captivating storytelling" that is "entertaining and engaging" and "never feels pedantic". [1] He was impressed by the way Rutherford dealt with such sensitive topics as race and eugenics, and that he used examples like earwax and lactose intolerance, rather than Mendel's exhumed pea plants to demonstrate how genetics work. Angrist concluded his review by stating: "If genetics can ever offer us words to live by, I reckon these are probably the best it can do." [1]
Nancy R. Curtis wrote in the Library Journal that A Brief History of Everyone Who Ever Lived should attract readers of both popular and technical science books. She said it is "amusing and provocative", and "may bruise the egos of a few genealogists". [9] Curtis did, however, complain that Rutherford gives too much attention to European and British issues, and from time to time "succumbs to editorializing on peripheral topics", for example creationism and genetic determinism. [9] In a review in The Wall Street Journal , Charles C. Mann was a little critical of the book's title, saying that it "is not particularly brief, not exactly a history and not concerned with everyone who ever lived". [10] But he was pleased that Rutherford did not fall into the trap of "hyping the science to sell the story" that popular science books often do. He said the author is "an enthusiastic guide and a good story-teller", although Mann did complain about Rutherford's many digressions that interrupt the flow of the text. [10]
Award | Year | Result |
---|---|---|
Wellcome Book Prize | 2017 | Longlisted [5] |
National Book Critics Circle Award | 2017 | Shortlisted [4] |
Foreword INDIE Gold Award for Science | 2017 | Won [2] |
Thomas Bonner Book Prize | 2018 | Won [3] |
Human evolution is the evolutionary process within the history of primates that led to the emergence of Homo sapiens as a distinct species of the hominid family, which includes all the great apes. This process involved the gradual development of traits such as human bipedalism, dexterity and complex language, as well as interbreeding with other hominins, indicating that human evolution was not linear but weblike. The study of human evolution involves several scientific disciplines, including physical and evolutionary anthropology, paleontology, and genetics.
Early modern human (EMH), or anatomically modern human (AMH), are terms used to distinguish Homo sapiens that are anatomically consistent with the range of phenotypes seen in contemporary humans, from extinct archaic human species. This distinction is useful especially for times and regions where anatomically modern and archaic humans co-existed, for example, in Paleolithic Europe. Among the oldest known remains of Homo sapiens are those found at the Omo-Kibish I archaeological site in south-western Ethiopia, dating to about 233,000 to 196,000 years ago, the Florisbad site in South Africa, dating to about 259,000 years ago, and the Jebel Irhoud site in Morocco, dated about 315,000 years ago.
Homo is the genus that emerged from the genus Australopithecus and encompasses the extant species Homo sapiens and several extinct species classified as either ancestral to or closely related to modern humans, including Homo erectus and Homo neanderthalensis. The oldest member of the genus is Homo habilis, with records of just over 2 million years ago. Homo, together with the genus Paranthropus, is probably sister to Australopithecus africanus, which itself had split from the lineage of Pan, the chimpanzees.
The Max Planck Institute for Evolutionary Anthropology is a research institute based in Leipzig, Germany, that was founded in 1997. It is part of the Max Planck Society network.
Microcephalin (MCPH1) is a gene that is expressed during fetal brain development. Certain mutations in MCPH1, when homozygous, cause primary microcephaly—a severely diminished brain. Hence, it has been assumed that variants have a role in brain development. However, in normal individuals no effect on mental ability or behavior has yet been demonstrated in either this or another similarly studied microcephaly gene, ASPM. However, an association has been established between normal variation in brain structure, as measured with MRI but only in females, and common genetic variants within both the MCPH1 gene and another similarly studied microcephaly gene, CDK5RAP2.
Paleogenetics is the study of the past through the examination of preserved genetic material from the remains of ancient organisms. Emile Zuckerkandl and Linus Pauling introduced the term in 1963, long before the sequencing of DNA, in reference to the possible reconstruction of the corresponding polypeptide sequences of past organisms. The first sequence of ancient DNA, isolated from a museum specimen of the extinct quagga, was published in 1984 by a team led by Allan Wilson.
The timeline of human evolution outlines the major events in the evolutionary lineage of the modern human species, Homo sapiens, throughout the history of life, beginning some 4 billion years ago down to recent evolution within H. sapiens during and since the Last Glacial Period.
A number of varieties of Homo are grouped into the broad category of archaic humans in the period that precedes and is contemporary to the emergence of the earliest early modern humans around 300 ka. Among the earliest remains of H. sapiens are Omo-Kibish I from southern Ethiopia, the remains from Jebel Irhoud in Morocco and Florisbad in South Africa (259 ka). The term typically includes H. antecessor, H. bodoensis, Denisovans (H. denisova), H. heidelbergensis (600–200 ka), Neanderthals, and H. rhodesiensis (300–125 ka).
Human evolutionary genetics studies how one human genome differs from another human genome, the evolutionary past that gave rise to the human genome, and its current effects. Differences between genomes have anthropological, medical, historical and forensic implications and applications. Genetic data can provide important insights into human evolution.
The Neanderthal genome project is an effort of a group of scientists to sequence the Neanderthal genome, founded in July 2006.
Early human migrations are the earliest migrations and expansions of archaic and modern humans across continents. They are believed to have begun approximately 2 million years ago with the early expansions out of Africa by Homo erectus. This initial migration was followed by other archaic humans including H. heidelbergensis, which lived around 500,000 years ago and was the likely ancestor of Denisovans and Neanderthals as well as modern humans. Early hominids had likely crossed land bridges that have now sunk.
Self-domestication is a scientific hypothesis that suggests that, similar to domesticated animals, there has been a process of artificial selection among members of the human species conducted by humans themselves. In this way, during the process of hominization, a preference for individuals with collaborative and social behaviors would have been shown to optimize the benefit of the entire group: docility, language, and emotional intelligence would have been enhanced during this process of artificial selection. The hypothesis is raised that this is what differentiated Homo sapiens from Homo neanderthalensis and Homo erectus.
Bruce Lahn is a Chinese-born American geneticist. Lahn came to the U.S. from China to continue his education in the late 1980s. He is the William B. Graham professor of Human Genetics at the University of Chicago. He is also the founder of the Center for Stem Cell Biology and Tissue Engineering at Sun Yat-sen University in Guangzhou, China. Lahn currently serves as the chief scientist of VectorBuilder, Inc.
In paleoanthropology, the recent African origin of modern humans or the "Out of Africa" theory (OOA) is the most widely accepted model of the geographic origin and early migration of anatomically modern humans. It follows the early expansions of hominins out of Africa, accomplished by Homo erectus and then Homo neanderthalensis.
The multiregional hypothesis, multiregional evolution (MRE), or polycentric hypothesis, is a scientific model that provides an alternative explanation to the more widely accepted "Out of Africa" model of monogenesis for the pattern of human evolution.
Adam David Rutherford is a British geneticist and science populariser. He was an audio-visual content editor for the journal Nature for a decade, and is a frequent contributor to the newspaper The Guardian. He hosts the BBC Radio 4 programmes Inside Science and The Curious Cases of Rutherford and Fry; has produced several science documentaries; and has published books related to genetics and the origin of life.
Yuval Noah Harari is an Israeli author, public intellectual, historian and professor in the Department of History at the Hebrew University of Jerusalem. He is the author of the popular science bestsellers Sapiens: A Brief History of Humankind (2014), Homo Deus: A Brief History of Tomorrow (2016), and 21 Lessons for the 21st Century (2018). His writings examine free will, consciousness, intelligence, happiness, and suffering.
Recent human evolution refers to evolutionary adaptation, sexual and natural selection, and genetic drift within Homo sapiens populations, since their separation and dispersal in the Middle Paleolithic about 50,000 years ago. Contrary to popular belief, not only are humans still evolving, their evolution since the dawn of agriculture is faster than ever before. It has been proposed that human culture acts as a selective force in human evolution and has accelerated it; however, this is disputed. With a sufficiently large data set and modern research methods, scientists can study the changes in the frequency of an allele occurring in a tiny subset of the population over a single lifetime, the shortest meaningful time scale in evolution. Comparing a given gene with that of other species enables geneticists to determine whether it is rapidly evolving in humans alone. For example, while human DNA is on average 98% identical to chimp DNA, the so-called Human Accelerated Region 1 (HAR1), involved in the development of the brain, is only 85% similar.
Carles Lalueza Fox is a Spanish biologist specialized in the study of ancient DNA. A doctor in Biology for the University of Barcelona, he worked in Cambridge and Oxford as well as in the private genetics company CODE Genetics of Iceland. Since 2008, he has served as a research Scientist in the Institute of Evolutionary Biology.