Acrosin binding protein

ACRBP
Identifiers
Aliases	ACRBP , CT23, OY-TES-1, SP32, acrosin binding protein
External IDs	OMIM: 608352; MGI: 1859515; HomoloGene: 9641; GeneCards: ACRBP; OMA:ACRBP - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.31 Start 6,638,075 bp [1] End 6,647,433 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 F2 Start 125,026,652 bp [2] End 125,040,230 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis monocyte sperm granulocyte blood spleen right lung gonad testicle Top expressed in superior surface of tongue gallbladder seminiferous tubule spermatid spermatocyte saccule otic placode otic vesicle neural layer of retina granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component cytoplasmic vesicle nucleus acrosomal vesicle extracellular region acrosomal membrane Biological process sperm capacitation biological process acrosome assembly spermatid development fertilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84519 54137 Ensembl ENSG00000111644 ENSMUSG00000072770 UniProt Q8NEB7 Q3V140 RefSeq (mRNA) NM_032489 NM_001127340 NM_016845 RefSeq (protein) NP_115878 NP_001120812 NP_058541 Location (UCSC) Chr 12: 6.64 – 6.65 Mb Chr 6: 125.03 – 125.04 Mb PubMed search [3] [4]
Wikidata
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Acrosin binding protein is a protein that in humans is encoded by the ACRBP gene. ^[5]

Function

The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon.

References

1. GRCh38: Ensembl release 89: ENSG00000111644 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000072770 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Acrosin binding protein" . Retrieved 2016-08-01.

Further reading

• Okumura H, Noguchi Y, Uenaka A, Aji T, Ono T, Nakagawa K, Aoe M, Shimizu N, Nakayama E (2005). "Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T-cells". Microbiol. Immunol. 49 (11): 1009–16. doi: 10.1111/j.1348-0421.2005.tb03688.x . PMID   16301813. S2CID   24003855.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.