African meningitis belt

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The meningitis belt, showing the distribution of meningococcal meningitis in Africa Meningococcal Meningitis Range.svg
The meningitis belt, showing the distribution of meningococcal meningitis in Africa

The African meningitis belt is a region in sub-Saharan Africa where the rate of incidence of meningitis is very high. It extends from Senegal to Ethiopia, and the primary cause of meningitis in the belt is Neisseria meningitidis .

Contents

The belt was first proposed by Léon Lapeyssonnie of the World Health Organization (WHO) in 1963. Lapeyssonnie noticed that the disease occurred in areas receiving 300–1,100 mm of mean annual rainfall, which is the case in sub-Saharan Africa. [1] The intercontinental spread of meningitis has also been traced to South Asia, brought by those making the Hajj, a pilgrimage to Saudi Arabia, in 1987, leading to epidemics in Nepal, Saudi Arabia, and Chad. [2]

Regions

It consists of part of or all of (from West to East), the Gambia, Senegal, Guinea-Bissau, Guinea, Mali, Burkina Faso, Ghana, Niger, Nigeria, Cameroon, Chad, Central African Republic, Sudan, South Sudan, Uganda, Kenya, Ethiopia, Eritrea. Many other countries in Africa experience outbreaks as well, but they are less frequent and less interepidemic. The "belt" has an estimated 300 million people in its total area. This region is not only prone to meningitis, [3] but also very prone to epidemics such as malaria.

The most affected countries in the region are Burkina Faso, Chad, Ethiopia, and Niger. Burkina Faso, Ethiopia, and Niger were accountable for 65% of all cases in Africa. In major epidemics, the attack rate range is 100 to 800 people per 100,000. However, communities can have attack rates as high as 1000 per 100,000. During these epidemics, young children have the highest attack rates. [4] More than 90,000 cases were reported in the belt in 2009, in comparison, less than 800 cases were reported in the United States [5] in 2011.

Epidemiology

Neisseria meningitidis is found in other parts of the world as well, but the highest rates occur in the “meningitis belt.” Meningococcal disease is persistently high in this region. Large epidemics occur every 5–12 years, typically during the dry season (December–June). Incidence of the disease declines from May to June in the more humid weather. [6] Other factors contributing to the sustained transmission of meningococcal disease include dust, other respiratory viruses that co-circulate, as well as close social contact. [7]

Historically, 90% of outbreaks in the meningitis belt were primarily due to Neisseria meningitidis serogroup A (NmA). [8] However, a monovalent serogroup A meningococcal conjugate vaccine (MenAfriVac) was introduced in the region in 2010. Since then, meningococcal outbreaks in the meningitis belt have primarily been due to serogroups C and W. A few serogroup X outbreaks have also been reported. [9]

In the African meningitis belt, the WHO defines a meningococcal epidemic as at least 100 cases per 100,000 inhabitants in a year. [10] At its peak, the incidence of meningococcal disease has reached rates of up to 1,000 cases per 100,000 inhabitants, such as during the epidemics of 1996 and 2000–2001. [11] In the belt, fatality from NmA disease has been estimated at 10–15%, although higher rates have been seen in some settings. [12] Around 10–20% of survivors of meningococcal meningitis are left with permanent neuropsychological conditions such as hearing loss, vision loss, epilepsy, or other neurological disorders. Young children are particularly vulnerable due to immaturity in their immune systems, which contributes to the disproportionate burden of the disease in Africa due to its young population. [13]

Meningitis vaccine

The Meningitis Vaccine Project was conceived in 2001 as an effort to stop the spread of meningitis in this region. [14]

References

  1. ↑ Lapeyssonnie, L. (November 1968). "[Comparative epidemiologic study of meningococcic cerebrospinal meningitis in temperate regions and in the meningitis belt in Africa. Attempt at synthesis]". Médecine Tropicale: Revue du Corps de Santé Colonial. 28 (6): 709–720. ISSN   0025-682X. PMID   5739513.
  2. ↑ Moore, P. S.; Reeves, M. W.; Schwartz, B.; Gellin, B. G.; Broome, C. V. (1989-07-29). "Intercontinental spread of an epidemic group A Neisseria meningitidis strain". Lancet. 2 (8657): 260–263. doi:10.1016/s0140-6736(89)90439-x. ISSN   0140-6736. PMID   2569063. S2CID   46601999.
  3. ↑ "Meningitis: Meningitis Belt". Archived from the original on 2008-05-19. Retrieved 2009-10-20.
  4. ↑ "Meningitis Vaccine Project: Epidemics in Africa". Archived from the original on 2014-04-29. Retrieved 2014-04-28.
  5. ↑ Murray, Patrick R.; Rosenthal, Ken S.; Pfaller, Michael A. (28 October 2015). Medical microbiology (8th ed.). Philadelphia, PA. ISBN   9780323299565. OCLC   914223501.{{cite book}}: CS1 maint: location missing publisher (link)
  6. ↑ Paireau, Juliette; Chen, Angelica; Broutin, Helene; Grenfell, Bryan; Basta, Nicole E (June 2016). "Seasonal dynamics of bacterial meningitis: a time-series analysis". The Lancet. Global Health. 4 (6): e370 –e377. doi:10.1016/S2214-109X(16)30064-X. ISSN   2214-109X. PMC   5516123 . PMID   27198841.
  7. ↑ Mustapha, Mustapha M.; Harrison, Lee H. (2018-01-16). "Vaccine prevention of meningococcal disease in Africa: Major advances, remaining challenges". Human Vaccines & Immunotherapeutics. 14 (5): 1107–1115. doi:10.1080/21645515.2017.1412020. ISSN   2164-5515. PMC   5989898 . PMID   29211624.
  8. ↑ Lingani, Clément; Bergeron-Caron, Cassi; Stuart, James M.; Fernandez, Katya; Djingarey, Mamoudou H.; Ronveaux, Olivier; Schnitzler, Johannes C.; Perea, William A. (2015-11-15). "Meningococcal Meningitis Surveillance in the African Meningitis Belt, 2004-2013". Clinical Infectious Diseases. 61 (Suppl 5): S410–415. doi:10.1093/cid/civ597. ISSN   1537-6591. PMC   4639499 . PMID   26553668.
  9. ↑ "Meningococcal Disease - Chapter 4 - 2020 Yellow Book | Travelers' Health | CDC". wwwnc.cdc.gov. Retrieved 2020-11-18.
  10. ↑ World Health Organization. "Weekly epidemiological record" (PDF).
  11. ↑ Al-Tawfiq, Jaffar (2010). "Meningococcal Disease: The Organism, Clinical Presentation, and Worldwide Epidemiology". Journal of Travel Medicine. 7: 3–8. doi: 10.1111/j.1708-8305.2010.00448.x . PMID   20849427.
  12. ↑ Greenwood, B. M.; Bradley, A. K.; Smith, A. W.; Wall, R. A. (1987). "Mortality from meningococcal disease during an epidemic in The Gambia, West Africa". Transactions of the Royal Society of Tropical Medicine and Hygiene. 81 (4): 536–538. doi:10.1016/0035-9203(87)90397-x. ISSN   0035-9203. PMID   3445333.
  13. ↑ Ramakrishnan, Meenakshi; Ulland, Aaron J; Steinhardt, Laura C; Moïsi, Jennifer C; Were, Fred; Levine, Orin S (2009-09-14). "Sequelae due to bacterial meningitis among African children: a systematic literature review". BMC Medicine. 7 47. doi: 10.1186/1741-7015-7-47 . ISSN   1741-7015. PMC   2759956 . PMID   19751516.
  14. ↑ Tiffay, Kathleen; Jodar, Luis; Kieny, Marie-Paule; Socquet, Muriel; LaForce, F. Marc (2015-11-09). "The Evolution of the Meningitis Vaccine Project". Clinical Infectious Diseases. 61 (suppl_5). Oxford University Press (OUP): S396 –S403. doi:10.1093/cid/civ594. ISSN   1537-6591. PMC   4639496 . PMID   26553666.
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