Agamid adenovirus

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Agamid adenovirus 1
Adenovirus 4.jpg
Transmission electron micrograph of two adenovirus particles
Virus classification
Group:
Group I (dsDNA)
Family:
Genus:
Species:
Agamid adenovirus 1

Wellehan

Agamid adenovirus (Agamid AdV1) is a type of virus in the Adenoviridae family. The virus is widespread in captive populations of Pogona vitticeps , known commonly as the central bearded dragon, in the United States. Other countries with confirmed cases are Australia, Japan, Germany, The Netherlands, Belgium, the UK, and El Salvador. [1] It is often discovered in association with other infections, and causes increased juvenile mortality and adult deaths. [2]

Contents

History

The first detection of adenovirus-like particles in Bearded Dragons was reported from New Zealand in 1982 (Julian and Durham, 1985). [2] Since then multiple studies have come out about the virus. University of Florida seems to lead with the most detailed and up to date reports, however University of Illinois is also known to be involved in research of the virus.

Diversity of agamid adenoviruses

Data have recently been published on the diversity of Agamid adenovirus 1 in the United States [3]

Agamid adenovirus 1 has also been identified in bearded dragons in Austria:

Infection and consequences

In a study published by the Journal of Virology, [4] intranuclear inclusions, or infected cells, were found in the intestinal mucosa, hepatocytes, and bile ducts. Even where an Agamid shows no signs of infection, many are believed to be sub-clinically infected, or carriers of the virus. Although they show no signs they can infect others. It is known that the virus is transferable through fecal-oral contact, however it is speculated that it can be passed in ways as of current research are unknown. Agamid Adenovirus is becoming widespread in the United States, with several breeders admitting infection and shutting down their current projects. However some breeders are still not convinced of the dangers of Agamid Adenovirus, thus they do not test, they could be selling Adenovirus positive offspring. A report from Louisiana State University [5] found that baby and juvenile Bearded Dragons have a high mortality rate associated with this virus.

The following is quoted from Cheri Smith's compilation of Adenovirus symptoms: [6] "Any animal that is suspected of having this virus should be isolated, never breed and great care taken when handling between animals. All animals in contact with another that is suspected of having it or confirmed should be isolated from each other, never bred, certainly never sold to others that may unknowingly start the cycle again with other animals. One confirmed case had a couple with an ill animal that brought it to a breeder to look at and he followed all safety precautions, only to find the couple handling some of his babies while he was looking at theirs, 10 days later his entire clutch was ill and dying, it passes that easily! Another breeder at a show in NY, returned from the show and had babies dying that tested positive within 2 weeks (since that time, 2 other breeders that attend the same show have also lost their colony of dragons to the virus)"

In 2005 it was noted by Cheri Smith that "Sibling clutches have been tested and some are positive, some are negative in the same clutch. This leads to the theory that some are infected when the eggs pass through the cloaca and pick up viral particles or some are infected before they are shelled when others are spared." [6]

Symptoms

Symptoms of Agamid Adenovirus 1 in bearded dragons are variable, and range from asymptomatic infection to enteritis to death. It is probable that there is a relationship between dose of infection and clinical disease. Coinfections with other agents such as Isospora amphibolouri, a coccidia, and dependovirus, a genus of [5] Parvovirus may play roles in clinical presentation of disease. Husbandry factors such as temperature range, diet, population density, and other stressors also are likely to play significant roles in clinical presentation.

Testing

Treatment

As of this revision of this article no vaccine, treatment or cure for Agamid Adenovirus 1 has been found.

Related Research Articles

<i>Pogona</i> genus of reptiles known as bearded dragons

Pogona is a genus of reptiles containing six lizard species which are often known by the common name bearded dragons. The name "bearded dragon" refers to the "beard" of the dragon, the underside of the throat, which can turn black and puff out for a number of reasons, most often as a result of stress, or if they feel threatened. They are a semi-arboreal species, spending significant amounts of time on branches, in bushes, and near human habitation. Pogona species bask on rocks and exposed branches in the mornings and afternoons. They are found throughout much of Australia in a wide range of habitats such as deserts, shrublands and Eucalyptus woodlands.

Central bearded dragon Species of lizard

The central bearded dragon, also known as the inland bearded dragon, is a species of agamid lizard found in a wide range of arid to semiarid regions of eastern and central Australia. It is the most popularly kept pet reptile, and often exhibited in zoos.

<i>Adenoviridae</i> Family of viruses

Adenoviruses are medium-sized, nonenveloped viruses with an icosahedral nucleocapsid containing a double stranded DNA genome. Their name derives from their initial isolation from human adenoids in 1953.

<i>Carnivore protoparvovirus 1</i> Species of parvovirus

Carnivore protoparvovirus 1 is a species of parvovirus that infects carnivorans. It causes a highly contagious disease in both dogs and cats. The disease is generally divided into two major genogroups: CPV-1 containing the classical feline panleukopenia virus (FPLV), and CPV-2 containing the canine parvovirus (CPV) which appeared in the 1970s.

Aviadenoviruses are adenoviruses that affect birds—particularly chickens, ducks, geese, turkeys and pheasants. There are currently fourteen species in this genus including the type species Fowl aviadenovirus A. Viruses in this genus cause specific disease syndromes such as Quail Bronchitis (QB), Egg Drop Syndrome (EDS), Haemorrhagic Enteritis (HE), Pheasant Marble Spleen Disease (MSD), Falcon adenovirus A and Inclusion Body Hepatitis (IBH). Avian adenoviruses have a worldwide distribution and it is common to find multiple species on a single farm. The most common serogroups are serogroup 1, 2 and 3.

Eastern bearded dragon Species of lizard

The eastern bearded dragon, also known as common bearded dragon or simply bearded lizard, is an agamid lizard found in wooded parts of Australia. It is one of a group of species known commonly as bearded dragons. Other common names for this species include Jew lizard and frilly lizard, the latter being a confusion between this and another dragon, the frill-necked lizard. This species was originally described in 1829 by Georges Cuvier, who named it Amphibolurus barbatus.

Viral pneumonia is a pneumonia caused by a virus. Pneumonia is an infection that causes inflammation in one or both of the lungs. The pulmonary alveoli fill with fluid or pus making it difficult to breathe. Pneumonia can be caused by bacteria, viruses, fungi, or parasites. Viruses are the most common cause of pneumonia in children, while in adults bacteria are a more common cause.

Adenovirus infections most commonly cause illness of the respiratory system; however, depending on the infecting serotype, they may also cause various other illnesses and presentations.

Astrovirus Family of viruses

Astroviruses are a type of virus that was first discovered in 1975 using electron microscopes following an outbreak of diarrhea in humans. In addition to humans, astroviruses have now been isolated from numerous mammalian animal species and from avian species such as ducks, chickens, and turkey poults. Astroviruses are 28–35 nm diameter, icosahedral viruses that have a characteristic five- or sixpointed star-like surface structure when viewed by electron microscopy. Along with the Picornaviridae and the Caliciviridae, the Astroviridae comprise a third family of nonenveloped viruses whose genome is composed of plus-sense, single-stranded RNA. Astrovirus has a non-segmented, single stranded, positive sense RNA genome within a non-enveloped icosahedral capsid. Human astroviruses have been shown in numerous studies to be an important cause of gastroenteritis in young children worldwide. In animals, Astroviruses also cause infection of the gastrointestinal tract but may also result in encephalitis, hepatitis (avian) and nephritis (avian).

Bovine alphaherpesvirus 1 (BoHV-1) is a virus of the family Herpesviridae and the subfamily Alphaherpesvirinae, known to cause several diseases worldwide in cattle, including rhinotracheitis, vaginitis, balanoposthitis, abortion, conjunctivitis, and enteritis. BoHV-1 is also a contributing factor in shipping fever, also known as bovine respiratory disease (BRD). It is spread horizontally through sexual contact, artificial insemination, and aerosol transmission and it may also be transmitted vertically across the placenta. BoHV-1 can cause both clinical and subclinical infections, depending on the virulence of the strain. Although these symptoms are mainly non-life-threatening it is an economically important disease as infection may cause a drop in production and affect trade restrictions. Like other herpesviruses, BoHV-1 causes a lifelong latent infection and sporadic shedding of the virus. The sciatic nerve and trigeminal nerve are the sites of latency. A reactivated latent carrier is normally the source of infection in a herd. The clinical signs displayed are dependent on the virulence of the strain. There is a vaccine available which reduces the severity and incidence of disease. Some countries in Europe have successfully eradicated the disease by applying a strict culling policy.

Aujeszky's disease, usually called pseudorabies in the United States, is a viral disease in swine that has been endemic in most parts of the world. It is caused by Suid herpesvirus 1 (SuHV-1). Aujeszky's disease is considered to be the most economically important viral disease of swine in areas where classical swine fever has been eradicated. Other mammals, such as cattle, sheep, goats, cats, dogs, and raccoons, are also susceptible. The disease is usually fatal in these animal species.

Equid alphaherpesvirus 1, formerly Equine herpesvirus 1 (EHV-1), is a virus of the family Herpesviridae that causes abortion, respiratory disease and occasionally neonatal mortality in horses. Initial spread of EHV-1 by a newly introduced horse through direct and indirect contact can lead to abortion and perinatal infection in up to 70 percent of a previously unexposed herd. Abortion usually occurs in the last four months of gestation, two to four weeks after infection of the mare. Perinatal infection can lead to pneumonia and death. Encephalitis can occur in affected animals, leading to ataxia, paralysis, and death. There is a vaccine available, however its efficacy is questionable. The virus varies in severity from sub-clinical to very severe. Most horses have been infected with EHV-1, but the virus can become latent and persist without ever causing signs of infection. In 2006, an outbreak of EHV-1 among stables in Florida resulted in the institution of quarantine measures. The outbreak was determined to have originated in horses imported from Europe via New York, before being shipped to Florida.

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Rankins dragon Species of lizard

Rankin's dragon is a species of Australian agamid lizard. It may also be called the pygmy bearded dragon and the black-soiled bearded dragon.

In the diagnostic laboratory virus infections can be confirmed by a multitude of methods. Diagnostic virology has changed rapidly due to the advent of molecular techniques and increased clinical sensitivity of serological assays.

Titi monkey adenovirus (TMAdV) is an adenovirus first identified in a New World titi monkey of the genus Callicebus, and the virus also infected at least two humans. It is a large DNA-based virus which can cause death in monkeys, and respiratory illness has been recorded in humans. It was first discovered in Davis, California, at the California National Primate Research Center. The discovery of TMAdV was made by the laboratory of Charles Chiu and the UCSF-Abbott Viral Diagnostics and Discovery Center, using a DNA microarray test called the ViroChip that is able to detect all known as well as novel viruses. The virus is genetically different from any other adenovirus, and the origin or reservoir for TMAdV is still unknown. The significance of the discovery lies in the fact that adenovirus infections have always been thought to be species-specific, and the existence of adenoviruses that can infect both monkeys and humans raises the possibility of zoonotic transmission of adenoviruses.

Adenovirus varieties have been explored extensively as a viral vector for gene therapy and also as an oncolytic virus.

Falcon aviadenovirus A is an avian adenovirus that infects birds of the genus Falco, commonly called falcons. The virus was first discovered in 1996 in an epizootic of inclusion body hepatitis and enteritis in aplomado and peregrine falcons. It can also infect orange-breasted falcons, taitas, merlins, and American kestrels.

Brincidofovir

Brincidofovir (CMX001) is an experimental antiviral drug being developed by Chimerix of Durham, NC, for the treatment of cytomegalovirus, adenovirus, poxvirus, and ebolavirus infections. Brincidofovir is a prodrug of cidofovir. Conjugated to a lipid, the compound is designed to release cidofovir intracellularly, allowing for higher intracellular and lower plasma concentrations of cidofovir, effectively increasing its activity against dsDNA viruses, as well as oral bioavailability.

Egg drop syndrome

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References

  1. "Adeno Knowledgebase Articles". Archived from the original on 2008-05-09. Retrieved 2008-03-17.
  2. 1 2 3 "Reptile Adenovirus PCR and Sequencing at the University of Florida PVM" (PDF). Archived from the original (PDF) on July 1, 2007.
  3. Parkin, Derek B; Archer, Linda L; Childress, April L; Wellehan Jr, James F.X (2009). "Genotype differentiation of Agamid Adenovirus 1 in bearded dragons (Pogona vitticeps) in the USA by hexon gene sequence". Infection, Genetics and Evolution. 9 (4): 501–6. doi:10.1016/j.meegid.2009.01.010. PMID   19460315.
  4. Wellehan, J. F. X; Johnson, A. J; Harrach, B; Benko, M; Pessier, A. P; Johnson, C. M; Garner, M. M; Childress, A; Jacobson, E. R (2004). "Detection and Analysis of Six Lizard Adenoviruses by Consensus Primer PCR Provides Further Evidence of a Reptilian Origin for the Atadenoviruses". Journal of Virology. 78 (23): 13366–9. doi:10.1128/JVI.78.23.13366-13369.2004. PMC   525023 . PMID   15542689.
  5. 1 2 Kim, Dae Young; Mitchell, Mark A; Bauer, Rudy W; Poston, Rob; Cho, Doo-Youn (2016). "An Outbreak of Adenoviral Infection in Inland Bearded Dragons (Pogona Vitticeps) Coinfected with Dependovirus and Coccidial Protozoa (Isospora Sp.)". Journal of Veterinary Diagnostic Investigation. 14 (4): 332–4. doi: 10.1177/104063870201400411 . PMID   12152815.
  6. 1 2 "Cheri Smith on "Adenovirus Symptoms"". Archived from the original on 2008-05-12.

Further reading