Coccidia

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Coccidia
Coccidia.JPG
Coccidia oocysts in a fecal flotation from a cat. The cat was underweight and had diarrhea, showing signs of coccidiosis.
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Clade: Diaphoretickes
Clade: SAR
Clade: Alveolata
Phylum: Apicomplexa
Class: Conoidasida
Subclass: Coccidia
Leuckart, 1879
Orders
Synonyms
  • Coccidiasina

Coccidia (Coccidiasina) are a subclass of microscopic, spore-forming, single-celled obligate intracellular parasites belonging to the apicomplexan class Conoidasida. [1] As obligate intracellular parasites, they must live and reproduce within an animal cell. Coccidian parasites infect the intestinal tracts of animals, [2] and are the largest group of apicomplexan protozoa.

Contents

Infection with these parasites is known as coccidiosis. Coccidia can infect all mammals, some birds, some fish, some reptiles, and some amphibians. Most species of coccidia are species-specific in their host. An exception is Toxoplasma gondii , which can infect all mammals, although it can only undergo sexual reproduction in cats. Depending on the species of coccidia, infection can cause fever, vomiting, diarrhea, muscle pain, and nervous system effects and changes to behavior, and may lead to death. Healthy adults may recover without medication—but those who are immunocompromised or young almost certainly require medication to prevent death. Humans generally become infected by eating under-cooked meat, but can contract infection with T. gondii by poor hygiene when handling cat waste.

Taxonomy

The class is divided into four orders, which are distinguished by the presence or absence of various asexual and sexual stages:

The order Eucoccidiorida is divided into two suborders. These two groups differ in their sexual development: syzygy for Adeleorina and independent gametes for Eimeriorina.

The first suborder, Adeleorina, comprises coccidia of invertebrates and the coccidia that alternate between blood-sucking invertebrates and various vertebrates; this group includes Haemogregarina and Hepatozoon . There are seven families in this suborder.

The second suborder, Eimeriorina, comprises coccidia of a variety of coccidia many of form cysts. A number of genera, including Toxoplasma and Sarcocystis , infect vertebrates.

Coccidiosis

Transmission

Infected animals spread spores called oocysts in their stool. The oocysts mature, called sporulation. When another animal passes over the location where the feces were deposited, it may pick up the spores, which it then ingests when grooming itself. Mice may ingest the spores and become infected. When another animal eats the mouse, it becomes infected.

Some species of coccidia are transmissible to humans, including toxoplasma and cryptosporidium. [3]

Infection

Inside the host, the sporulated oocyst opens, and eight sporozoites are released. Each one finds a home in an intestinal cell and starts the process of reproduction. These offspring are called merozoites. When the cell is stuffed full of merozoites, it bursts open, and each merozoite finds its own intestinal cell to continue the cycle. [3]

Symptoms of infection

As the infection continues, millions of intestinal cells may become infected. As they break open, they produce a bloody, watery diarrhea. This can cause dehydration, and can lead to death in young or small pets. [3] Coccidian infections display symptoms mainly from the digestive tract including diarrhea, inflammation, intestinal pain or damage, vomiting, and irregular nutrition. These can lead to weight loss or reduced growth development, anemia, exhaustion, and even death in severe cases. [4]

Diagnosis and treatment

Coccidiosis can be diagnosed by finding oocysts in fecal smears. In early stages of the disease, there may be very few oocysts being shed, and a negative test does not rule out the disease.

Coccidiosis is most commonly treated through the administration of coccidiostats, a group of medications that stop coccidia from reproducing. In dogs and cats, the most commonly administered coccidiostat is sulfa-based antibiotics. Once reproduction stops, the animal can usually recover on its own, a process that can take a few weeks, depending on the severity of the infection and the strength of the animal's immune system. [3]

See also

Related Research Articles

<span class="mw-page-title-main">Apicomplexa</span> Phylum of parasitic alveolates

The Apicomplexa are organisms of a large phylum of mainly parasitic alveolates. Most possess a unique form of organelle structure that comprises a type of (non-photosynthetic) plastid called an apicoplast—with an apical complex membrane. The organelle's apical shape is an adaptation that the apicomplexan applies in penetrating a host cell.

<i>Toxoplasma gondii</i> Type of protozoan parasite

Toxoplasma gondii is a parasitic protozoan that causes toxoplasmosis. Found worldwide, T. gondii is capable of infecting virtually all warm-blooded animals, but felids are the only known definitive hosts in which the parasite may undergo sexual reproduction.

<span class="mw-page-title-main">Cryptosporidiosis</span> Parasitic disease

Cryptosporidiosis, sometimes informally called crypto, is a parasitic disease caused by Cryptosporidium, a genus of protozoan parasites in the phylum Apicomplexa. It affects the distal small intestine and can affect the respiratory tract in both immunocompetent and immunocompromised individuals, resulting in watery diarrhea with or without an unexplained cough. In immunosuppressed individuals, the symptoms are particularly severe and can be fatal. It is primarily spread through the fecal-oral route, often through contaminated water; recent evidence suggests that it can also be transmitted via fomites contaminated with respiratory secretions.

<span class="mw-page-title-main">Isosporiasis</span> Human intestinal disease

Isosporiasis, also known as cystoisosporiasis, is a human intestinal disease caused by the parasite Cystoisospora belli. It is found worldwide, especially in tropical and subtropical areas. Infection often occurs in immuno-compromised individuals, notably AIDS patients, and outbreaks have been reported in institutionalized groups in the United States. The first documented case was in 1915. It is usually spread indirectly, normally through contaminated food or water (CDC.gov).

Coccidiosis is a parasitic disease of the intestinal tract of animals caused by coccidian protozoa. The disease spreads from one animal to another by contact with infected feces or ingestion of infected tissue. Diarrhea, which may become bloody in severe cases, is the primary symptom. Most animals infected with coccidia are asymptomatic, but young or immunocompromised animals may suffer severe symptoms and death.

<i>Eimeria tenella</i> Species of single-celled organism

Eimeria tenella is a species of Eimeria that causes hemorrhagic cecal coccidiosis in young poultry. It is found worldwide.

<i>Eimeria</i> Genus of single-celled organisms

Eimeria is a genus of apicomplexan parasites that includes various species capable of causing the disease coccidiosis in animals such as cattle, poultry and smaller ruminants including sheep and goats. Eimeria species are considered to be monoxenous because the life cycle is completed within a single host, and stenoxenous because they tend to be host specific, although a number of exceptions have been identified. Species of this genus infect a wide variety of hosts. Thirty-one species are known to occur in bats (Chiroptera), two in turtles, and 130 named species infect fish. Two species infect seals. Five species infect llamas and alpacas: E. alpacae, E. ivitaensis, E. lamae, E. macusaniensis, and E. punonensis. A number of species infect rodents, including E. couesii, E. kinsellai, E. palustris, E. ojastii and E. oryzomysi. Others infect poultry, rabbits and cattle. For full species list, see below.

<i>Cryptosporidium parvum</i> Species of single-celled organism

Cryptosporidium parvum is one of several species that cause cryptosporidiosis, a parasitic disease of the mammalian intestinal tract.

<i>Cryptosporidium</i> Genus of single-celled organisms

Cryptosporidium, sometimes called crypto, is an apicomplexan genus of alveolates which are parasites that can cause a respiratory and gastrointestinal illness (cryptosporidiosis) that primarily involves watery diarrhea, sometimes with a persistent cough.

<span class="mw-page-title-main">Gregarinasina</span> Subclass of protists

The gregarines are a group of Apicomplexan alveolates, classified as the Gregarinasina or Gregarinia. The large parasites inhabit the intestines of many invertebrates. They are not found in any vertebrates. Gregarines are closely related to both Toxoplasma and Plasmodium, which cause toxoplasmosis and malaria, respectively. Both protists use protein complexes similar to those that are formed by the gregarines for gliding motility and for invading target cells. This makes the gregarines excellent models for studying gliding motility, with the goal of developing treatment options for both toxoplasmosis and malaria. Thousands of different species of gregarine are expected to be found in insects, and 99% of these gregarine species still need to be described. Each insect species can be the host of multiple gregarine species. One of the most-studied gregarines is Gregarina garnhami. In general, gregarines are regarded as a very successful group of parasites, as their hosts are distributed over the entire planet.

<i>Sarcocystis</i> Genus of protists in the apicomplex phylum

Sarcocystis is a genus of protozoan parasites, with many species infecting mammals, reptiles and birds. Its name is dervived from Greek sarx = flesh and kystis = bladder.

<span class="mw-page-title-main">Eucoccidiorida</span> Order of microscopic, spore-forming, single-celled parasites in the apicomplex phylum

The Eucoccidiorida are an order of microscopic, spore-forming, single-celled parasites belonging to the apicomplexan class Conoidasida. Protozoans of this order include parasites of humans, and both domesticated and wild animals including birds. Among these parasites are the Toxoplasma gondii that cause toxoplasmosis and Isospora belli, which results in isosporiasis.

<span class="mw-page-title-main">Protozoan infection</span> Parasitic disease caused by a protozoan

Protozoan infections are parasitic diseases caused by organisms formerly classified in the kingdom Protozoa. These organisms are now classified in the supergroups Excavata, Amoebozoa, Harosa, and Archaeplastida. They are usually contracted by either an insect vector or by contact with an infected substance or surface.

<span class="mw-page-title-main">Adeleorina</span> Suborder of microscopic, spore-forming, single-celled parasites in the aplcomplex phylum

Adeleorina is a suborder of parasites in the phylum Apicomplexa.

<span class="mw-page-title-main">Apicomplexan life cycle</span> Apicomplexa life cycle

Apicomplexans, a group of intracellular parasites, have life cycle stages that allow them to survive the wide variety of environments they are exposed to during their complex life cycle. Each stage in the life cycle of an apicomplexan organism is typified by a cellular variety with a distinct morphology and biochemistry.

Goussia is a taxonomic genus, first described in 1896 by Labbé, containing parasitic protists which largely target fish and amphibians as their hosts. Members of this genus are homoxenous and often reside in the gastrointestinal tract of the host, however others may be found in organs such as the gallbladder or liver. The genera Goussia, as current phylogenies indicate, is part of the class Conoidasida, which is a subset of the parasitic phylum Apicomplexa; features of this phylum, such as a distinct apical complex containing specialized secretory organelles, an apical polar ring, and a conoid are all present within Goussia, and assist in the mechanical invasion of host tissue. The name Goussia is derived from the French word gousse, meaning pod. This name is based on the bi-valve sporocyst morphology which some Goussians display. Of the original 8 classified Goussians, 6 fit the “pod” morphology. As of this writing, the genera consists of 59 individual species.

<i>Cystoisospora belli</i> Species of single-celled organism

Cystoisospora belli, previously known as Isospora belli, is a parasite that causes an intestinal disease known as cystoisosporiasis. This protozoan parasite is opportunistic in immune suppressed human hosts. It primarily exists in the epithelial cells of the small intestine, and develops in the cell cytoplasm. The distribution of this coccidian parasite is cosmopolitan, but is mainly found in tropical and subtropical areas of the world such as the Caribbean, Central and S. America, India, Africa, and S.E. Asia. In the U.S., it is usually associated with HIV infection and institutional living.

Hammondia hammondi is a species of obligate heteroxenous parasitic alveolates of domestic cats. Intracellular cysts develop mainly in striated muscle. After the ingestion of cysts by cats, a multiplicative cycle precedes the development of gametocytes in the epithelium of the small intestine. Oocyst shedding persists for 10 to 28 days followed by immunity. Cysts in skeletal muscle measure between 100 and 340 μm in length and 40 and 95 μm in width. Some of the intermediate hosts develop low levels of antibody and some cross-immunity against Toxoplasma.

Cystoisospora canis, previously known as Isospora canis, is a microscopic, coccidian parasite that causes an intestinal tract infection in dogs. The intestinal tract infection is coccidiosis caused by a protozoa called coccidia.

Eimeria zuernii is a species of the parasite Eimeria that causes diarrheic disease known as eimeriosis in cattle, and mainly affects younger animals. The disease is also commonly referred to as coccidiosis. The parasite can be found in cattle around the globe.

References

  1. Brands SJ (2000). "The Taxonomicon & Systema Naturae" (Website database). Taxon: Genus Cryptosporidium. Amsterdam, the Netherlands: Universal Taxonomic Services.
  2. "Biodiversity explorer: Apicomplexa (apicomplexans, sporozoans)". Iziko Museums of Cape Town. Archived from the original on 2006-09-23. Retrieved 2006-10-13.
  3. 1 2 3 4 "Coccidia". Mar Vista Animal Medical Center. Archived from the original on 1 November 2015. Retrieved 28 September 2015.
  4. Yan X, Liu M, He S, Tong T, Liu Y, Ding K, et al. (2021-05-19). Clegg S (ed.). "An epidemiological study of gastrointestinal nematode and Eimeria coccidia infections in different populations of Kazakh sheep". PLOS ONE. 16 (5): e0251307. doi: 10.1371/journal.pone.0251307 . PMC   8133398 . PMID   34010315.

Further reading