Alcohol dehydrogenase, iron containing 1

Last updated
ADHFE1
Identifiers
Aliases ADHFE1 , ADH8, HOT, HMFT2263, alcohol dehydrogenase, iron containing 1, alcohol dehydrogenase iron containing 1
External IDs MGI: 1923437 HomoloGene: 5865 GeneCards: ADHFE1
Gene location (Human)
Ideogram human chromosome 8.svg
Chr. Chromosome 8 (human) [1]
Human chromosome 8 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 8q13.1Start66,432,486 bp [1]
End66,468,907 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

137872

76187

Ensembl

ENSG00000147576

ENSMUSG00000025911

UniProt

Q8IWW8

Q8R0N6

RefSeq (mRNA)

NM_144650

NM_175236
NM_001357376
NM_001357377
NM_001357378

RefSeq (protein)

NP_653251

NP_780445
NP_001344305
NP_001344306
NP_001344307

Location (UCSC) Chr 8: 66.43 – 66.47 Mb Chr 1: 9.55 – 9.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alcohol dehydrogenase, iron containing 1 is a protein that in humans is encoded by the ADHFE1 gene. [5]

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Contents

Function

The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues. [6]

In enzymology, a hydroxyacid-oxoacid transhydrogenase is an enzyme that catalyzes the chemical reaction

Related Research Articles

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Dihydropyrimidine dehydrogenase

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SDHA protein-coding gene in the species Homo sapiens

Succinate dehydrogenase complex, subunit A, flavoprotein variant is a protein that in humans is encoded by the SDHA gene. This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. SDHA contains the FAD binding site where succinate is deprotonated and converted to fumarate. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Long-chain-aldehyde dehydrogenase protein-coding gene in the species Homo sapiens

Fatty aldehyde dehydrogenase is an aldehyde dehydrogenase enzyme that in human is encoded in the ALDH3A2 gene on chromosome 17. Aldehyde dehydrogenase enzymes function to remove toxic aldehydes that are generated by the metabolism of alcohol and by lipid peroxidation.

In enzymology, a 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) is an enzyme that catalyzes the chemical reaction

Xanthine dehydrogenase protein-coding gene in the species Homo sapiens

Xanthine dehydrogenase, also known as XDH, is a protein that, in humans, is encoded by the XDH gene.

UDP-glucose 6-dehydrogenase protein-coding gene in the species Homo sapiens

UDP-glucose 6-dehydrogenase is a cytosolic enzyme that in humans is encoded by the UGDH gene.

ADH1B protein-coding gene in the species Homo sapiens

Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene.

AKR1C3 protein-coding gene in the species Homo sapiens

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene.

AKR1C1 protein-coding gene in the species Homo sapiens

Aldo-keto reductase family 1 member C1 also known as 20α-hydroxysteroid dehydrogenase, 3α-hydroxysteroid dehydrogenase, and dihydrodiol dehydrogenase 1/2 is an enzyme that in humans is encoded by the AKR1C1 gene.

3α-Hydroxysteroid dehydrogenase protein-coding gene in the species Homo sapiens

3α-Hydroxysteroid dehydrogenase is an enzyme that in humans is encoded by the AKR1C4 gene. It is known to be necessary for the synthesis of the endogenous neurosteroids allopregnanolone, THDOC, and 3α-androstanediol. It is also known to catalyze the reversible conversion of 3α-androstanediol (5α-androstane-3α,17β-diol) to dihydrotestosterone and vice versa.

D2HGDH protein-coding gene in the species Homo sapiens

D-2-hydroxyglutarate dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the D2HGDH gene.

ADH7 protein-coding gene in the species Homo sapiens

Alcohol dehydrogenase class 4 mu/sigma chain is an enzyme that in humans is encoded by the ADH7 gene.

IDH3B protein-coding gene in the species Homo sapiens

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial is an enzyme that in humans is encoded by the IDH3B gene.

BDH1 protein-coding gene in the species Homo sapiens

D-beta-hydroxybutyrate dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the BDH1 gene.

ADH6 protein-coding gene in the species Homo sapiens

Alcohol dehydrogenase 6 is an enzyme that in humans is encoded by the ADH6 gene.

ACAD8 protein-coding gene in the species Homo sapiens

Isobutyryl-CoA dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ACAD8 gene on chromosome 11.

L2HGDH protein-coding gene in the species Homo sapiens

L-2-hydroxyglutarate dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the L2HGDH gene, also known as C14orf160, on chromosome 14.

Lactate dehydrogenase b protein-coding gene in the species Homo sapiens

Lactate dehydrogenase B is a protein that in humans is encoded by the LDHB gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000147576 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025911 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Alcohol dehydrogenase, iron containing 1" . Retrieved 2017-06-16.
  6. ↑ Kardon T, Noël G, Vertommen D, Schaftingen EV (April 2006). "Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate". FEBS Letters. 580 (9): 2347–50. doi:10.1016/j.febslet.2006.02.082. PMID   16616524.

Further reading

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