Alcohol dehydrogenase, iron containing 1

ADHFE1
Identifiers
Aliases	ADHFE1 , ADH8, HOT, HMFT2263, alcohol dehydrogenase, iron containing 1, alcohol dehydrogenase iron containing 1
External IDs	OMIM: 611083; MGI: 1923437; HomoloGene: 5865; GeneCards: ADHFE1; OMA:ADHFE1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q13.1 Start 66,432,492 bp [1] End 66,468,907 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 A2 Start 9,618,173 bp [2] End 9,650,898 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver gastric mucosa myocardium of left ventricle muscle of thigh tibialis anterior muscle deltoid muscle gastrocnemius muscle quadriceps femoris muscle apex of heart vastus lateralis muscle Top expressed in right kidney muscle of thigh zygote proximal tubule esophagus nucleus pulposus dentate gyrus of hippocampal formation granule cell morula superior frontal gyrus renal pelvis More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity metal ion binding hydroxyacid-oxoacid transhydrogenase activity alcohol dehydrogenase (NAD+) activity Cellular component mitochondrial matrix mitochondrion cytosol Biological process 2-oxoglutarate metabolic process glutamate catabolic process via 2-oxoglutarate Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 137872 76187 Ensembl ENSG00000147576 ENSMUSG00000025911 UniProt Q8IWW8 Q8R0N6 RefSeq (mRNA) NM_144650 NM_175236 NM_001357376 NM_001357377 NM_001357378 RefSeq (protein) NP_653251 NP_780445 NP_001344305 NP_001344306 NP_001344307 Location (UCSC) Chr 8: 66.43 – 66.47 Mb Chr 1: 9.62 – 9.65 Mb PubMed search [3] [4]
Wikidata
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Alcohol dehydrogenase, iron containing 1 is a protein that in humans is encoded by the ADHFE1 gene. ^[5]

Function

The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000147576 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025911 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Alcohol dehydrogenase, iron containing 1" . Retrieved 2017-06-16.
6. Kardon T, Noël G, Vertommen D, Schaftingen EV (April 2006). "Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate". FEBS Letters. 580 (9): 2347–50. doi: 10.1016/j.febslet.2006.02.082 . PMID   16616524. S2CID   46525441.

Further reading

• Deng Y, Wang Z, Gu S, Ji C, Ying K, Xie Y, Mao Y (October 2002). "Cloning and characterization of a novel human alcohol dehydrogenase gene (ADHFe1)". DNA Sequence. 13 (5): 301–6. doi:10.1080/1042517021000011636. PMID   12592711. S2CID   24529446.
• Lyon RC, Johnston SM, Panopoulos A, Alzeer S, McGarvie G, Ellis EM (March 2009). "Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1". Chemico-Biological Interactions. 178 (1–3): 283–7. Bibcode:2009CBI...178..283L. doi:10.1016/j.cbi.2008.10.025. PMID   19013439.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (September 2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9) e12862. Bibcode:2010PLoSO...512862H. doi: 10.1371/journal.pone.0012862 . PMC   2943476 . PMID   20877624.
• Tae CH, Ryu KJ, Kim SH, Kim HC, Chun HK, Min BH, Chang DK, Rhee PL, Kim JJ, Rhee JC, Kim YH (March 2013). "Alcohol dehydrogenase, iron containing, 1 promoter hypermethylation associated with colorectal cancer differentiation". BMC Cancer. 13: 142. doi: 10.1186/1471-2407-13-142 . PMC   3618294 . PMID   23517143.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.