Alison Rodger

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Alison Rodger
2019-09-06 Joanne Stephan-119 (2).jpg
Alma mater University of Sydney
Moore Theological College
University of Oxford
University of Chester
Known forBiomacromolecules
Scientific career
Institutions Macquarie University
University of Warwick
University of Oxford
University of Cambridge

Alison Rodger FRSC FRACI FAA CChem (born November 21, 1959) is a professor of chemistry at Macquarie University. Her research considers biomacromolecular structures and their characterisation. She is currently developing Raman Linear Difference Spectroscopy and fluorescence detected liner dichroism to understand biomacromolecular structure and interactions with application to the division of bacterial cells.

Contents

Early life and education

Rodger was born in Edinburgh to John and Margaret McDougall. [1] She earned her bachelor's, PhD and DSc from University of Sydney. [2] She was awarded the University of Sydney University Medal for theoretical chemistry. Whilst a student, Roger developed Classical Selection Rule (CSR), a procedure that can be used to analyse reaction mechanisms. [3] [4] In 1985 she completed a diploma in Biblical Studies at Moore Theological College. She gained a master's degree at the University of Oxford in 1988. She moved to the University of Warwick for a second DSc, and earned a bachelor's degree in theology at the University of Chester. [5] Rodger was appointed a Beatrice Dale Fellowship at Newnham College, Cambridge from 1985 to 1988. [5]

Research and career

In 1985 Rodger joined Newnham College Cambridge as a Beatrice Dale Research fellow. 1988 Rodger she moved to the University of Oxford as a Unilever Fellow in St Catherine's College. She moved to St Hilda's College in 1991.[ citation needed ] She developed the UK's first Couette flow linear dichroism facilities. [6] [7] In 1994 Rodger joined the University of Warwick as a Lecturer. She was made a Senior Lecturer in 1998, a Reader in 2003 and a Professor in 2005. Rodger was Head of the Department of Chemistry at the University of Warwick from 2014 to 2016. [5] She was the only woman academic in the Physical Chemistry Laboratory at Oxford and the Department of Chemistry at the University of Warwick for over 11 years. [8] She has been involved with several initiatives to improve gender balance in academic chemistry, including Athena SWAN and a European partnership, PLOTINA (Promoting Gender Balance and Inclusion in Research, Innovation and Training). [9] [10] [11] [12] PLOTINA looked to drive cultural change by developing diverse, inclusive work environments. [9] Under Rodger's leadership, Warwick achieved the fourth institution to achieve silver Athena SWAN status. [10] She was the founder and Director of the Doctoral Training Centre in Molecular Organisation and Assembly in Cells. [13] [14] The Doctoral Training Centre was one of the first EPSRC-funded DTCs. [14] She developed a postgraduate certificate in transferable skills to support early career researchers. [5]

Rodger is interested in how the structure and arrangement of biomolecules impact their function. [15] She developed the technology for UV- Linear Dichroism spectroscopy. [15] Her lab became the national and international hub of Couette flow Linear Dichroism, allowing scientists to obtain structural and kinetic information about several systems. [16] She demonstrated that it is possible to orient membrane systems of liposomes. [16] Rodgers developed Raman Linear Difference Spectroscopy to study the division of bacterial cells. [15] She designed a new instrument that could measure Raman optical activity and Raman Linear Difference Spectroscopy in an effort to probe the secondary and tertiary structures of biomacromolecules. [15] [17] Her research in the UK was supported by the Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council. [18] Rodger serves on the advisory board of the Protein Circular Dichroism Data Bank. [19] In 2015 she was named on the Analytical Science Power List. She joined the council at St John's College, Nottingham in 2015. [1] Rodger completed a bachelor's degree in Theology at St John's College whilst working as a Professor of Biophysical Chemistry. [20] She serves on the Australian Research Council Science and Technology Advisory Panel. [21] [22]

She moved to Macquarie University in 2017, where she is establishing an open-access biophysical spectroscopy facility for collaborators. [23] Alongside investigating circular dichroism of biomacromolecules, Rodgers has studied molecular electronic systems. [24] [25] She co-led the UK Circular and Linear Dichroism Summer School for over 10 years. [26] She was a member of the Royal Society of Chemistry Council until she left the UK in 2017. She was very involved in Athena SWAN in the UK and is part of the Athena SWAN expansion in Australia, SAGE. [27] She is a member of Barker College Council and an Honorary Member of the British Biophysical Society.

In 2021 she received the accolade of election as Fellow of the Australian Academy of Science. [28]

Books

Related Research Articles

<span class="mw-page-title-main">Dichroism</span> Phenomenon where the material is splitting two or more beams of different colours

In optics, a dichroic material is either one which causes visible light to be split up into distinct beams of different wavelengths (colours), or one in which light rays having different polarizations are absorbed by different amounts.

Circular dichroism (CD) is dichroism involving circularly polarized light, i.e., the differential absorption of left- and right-handed light. Left-hand circular (LHC) and right-hand circular (RHC) polarized light represent two possible spin angular momentum states for a photon, and so circular dichroism is also referred to as dichroism for spin angular momentum. This phenomenon was discovered by Jean-Baptiste Biot, Augustin Fresnel, and Aimé Cotton in the first half of the 19th century. Circular dichroism and circular birefringence are manifestations of optical activity. It is exhibited in the absorption bands of optically active chiral molecules. CD spectroscopy has a wide range of applications in many different fields. Most notably, UV CD is used to investigate the secondary structure of proteins. UV/Vis CD is used to investigate charge-transfer transitions. Near-infrared CD is used to investigate geometric and electronic structure by probing metal d→d transitions. Vibrational circular dichroism, which uses light from the infrared energy region, is used for structural studies of small organic molecules, and most recently proteins and DNA.

<span class="mw-page-title-main">Raman optical activity</span>

Raman optical activity (ROA) is a vibrational spectroscopic technique that is reliant on the difference in intensity of Raman scattered right and left circularly polarised light due to molecular chirality.

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<span class="mw-page-title-main">Molecular biophysics</span> Interdisciplinary research area

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Vibrational circular dichroism (VCD) is a spectroscopic technique which detects differences in attenuation of left and right circularly polarized light passing through a sample. It is the extension of circular dichroism spectroscopy into the infrared and near infrared ranges.

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The following outline is provided as an overview of and topical guide to biophysics:

<span class="mw-page-title-main">Macromolecular assembly</span>

The term macromolecular assembly (MA) refers to massive chemical structures such as viruses and non-biologic nanoparticles, cellular organelles and membranes and ribosomes, etc. that are complex mixtures of polypeptide, polynucleotide, polysaccharide or other polymeric macromolecules. They are generally of more than one of these types, and the mixtures are defined spatially, and with regard to their underlying chemical composition and structure. Macromolecules are found in living and nonliving things, and are composed of many hundreds or thousands of atoms held together by covalent bonds; they are often characterized by repeating units. Assemblies of these can likewise be biologic or non-biologic, though the MA term is more commonly applied in biology, and the term supramolecular assembly is more often applied in non-biologic contexts. MAs of macromolecules are held in their defined forms by non-covalent intermolecular interactions, and can be in either non-repeating structures, or in repeating linear, circular, spiral, or other patterns. The process by which MAs are formed has been termed molecular self-assembly, a term especially applied in non-biologic contexts. A wide variety of physical/biophysical, chemical/biochemical, and computational methods exist for the study of MA; given the scale of MAs, efforts to elaborate their composition and structure and discern mechanisms underlying their functions are at the forefront of modern structure science.

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<span class="mw-page-title-main">Hyper–Rayleigh scattering</span> Optical phenomenon

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Synchrotron radiation circular dichroism spectroscopy, commonly referred to as SRCD and also known as VUV-circular dichroism or VUVCD spectroscopy, is a powerful extension to the technique of circular dichroism (CD) spectroscopy, often used to study structural properties of biological molecules such as proteins and nucleic acids. The physical principles of SRCD are essentially identical to those of CD, in that the technique measures the difference in absorption (ΔA) of left (AL) and right (AR) circularly polarized light (ΔA=AL-AR) by a sample in solution. To obtain a CD(SRCD) spectrum the sample must be innately optically active (chiral), or, in some way be induced to have chiral properties, as only then will there be an observable difference in absorption of the left and right circularly polarized light. The major advantages of SRCD over CD arise from the ability to measure data over an extended wavelength range into the vacuum ultra violet (VUV) end of the spectrum. As these measurements are utilizing a light source with a higher photon flux than a bench-top CD machine it means data are more accurate at these extended wavelengths because there is a larger signal over the background noise and, generally, less sample is needed when recording the spectra and there is more information content available in the data. Many beamlines now exist around the world to enable the measurement of SRCD data.

References

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  3. Rodger, Alison; Schipper, Pieter E. (1 February 1988). "Symmetry selection rules for reaction mechanisms: application to metal-ligand isomerizations". Inorganic Chemistry. 27 (3): 458–466. doi:10.1021/ic00276a006. ISSN   0020-1669.
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  7. Marrington, R.; Dafforn, T. R.; Halsall, D. J.; Rodger, A. (September 2004). "Micro-Volume Couette Flow Sample Orientation for Absorbance and Fluorescence Linear Dichroism". Biophysical Journal. 87 (3): 2002–2012. Bibcode:2004BpJ....87.2002M. doi:10.1529/biophysj.103.035022. PMC   1304603 . PMID   15345576.
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  30. Nordén, Bengt; Rodger, Alison; Dafforn, Tim (2010). Linear Dichroism and Circular Dichroism: A Textbook on Polarized-light Spectroscopy. Royal Society of Chemistry. ISBN   9781847559029.