Allograft inflammatory factor 1-like

AIF1L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JJZ, 2VTG
Identifiers
Aliases	AIF1L , C9orf58, IBA2, allograft inflammatory factor 1 like
External IDs	MGI: 1919598 HomoloGene: 12863 GeneCards: AIF1L
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.12-q34.13 Start 131,096,476 bp [1] End 131,123,152 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 31,840,151 bp [2] End 31,863,454 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla inferior ganglion of vagus nerve kidney spleen internal globus pallidus ventral tegmental area medulla oblongata substantia nigra spinal ganglia trigeminal ganglion Top expressed in stria vascularis cumulus cell ciliary body subiculum Region I of hippocampus proper retinal pigment epithelium maxillary prominence piriform cortex superior colliculus atrium More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding actin filament binding actin binding metal ion binding Cellular component cytoplasm actin cytoskeleton ruffle membrane plasma membrane cell projection extracellular exosome cytoskeleton membrane focal adhesion actin filament protein-containing complex Biological process actin filament bundle assembly ruffle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83543 108897 Ensembl ENSG00000126878 ENSMUSG00000001864 UniProt Q9BQI0 Q9EQX4 RefSeq (mRNA) NM_001002260 NM_001185095 NM_001185096 NM_031426 NM_145144 RefSeq (protein) NP_001172024 NP_001172025 NP_113614 NP_660126 Location (UCSC) Chr 9: 131.1 – 131.12 Mb Chr 2: 31.84 – 31.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Allograft inflammatory factor 1-like is a protein that is encoded by the AIF1L gene in humans. ^{[5] [6]}

AIF1L is an actin-binding protein that promotes actin bundling. It may neither bind calcium nor depend on calcium for function. ^[7] It has biased expression in kidney (RPKM 130.1), spleen (RPKM 121.3) and 8 other tissues. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000126878 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001864 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. "Entrez Gene: C9orf58 chromosome 9 open reading frame 58".
7. "Aif1l - Allograft inflammatory factor 1-like - Mus musculus (Mouse) - Aif1l gene & protein". www.uniprot.org. Retrieved 3 December 2017.
8. "AIF1L allograft inflammatory factor 1 like [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 3 December 2017.

External links

• Human AIF1L genome location and AIF1L gene details page in the UCSC Genome Browser .

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.