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Pathology is the study of disease and injury. The word pathology also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area that includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue and human cell samples. Idiomatically, "a pathology" may also refer to the predicted or actual progression of particular diseases, and the affix pathy is sometimes used to indicate a state of disease in cases of both physical ailment and psychological conditions. A physician practicing pathology is called a pathologist.
Anatomical pathology (Commonwealth) or anatomic pathology (U.S.) is a medical specialty that is concerned with the diagnosis of disease based on the macroscopic, microscopic, biochemical, immunologic and molecular examination of organs and tissues. Over the 20th century, surgical pathology has evolved tremendously: from historical examination of whole bodies (autopsy) to a more modernized practice, centered on the diagnosis and prognosis of cancer to guide treatment decision-making in oncology. Its modern founder was the Italian scientist Giovanni Battista Morgagni from Forlì.
Pathophysiology is a branch of study, at the intersection of pathology and physiology, concerning disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury. Pathology is the medical discipline that describes conditions typically observed during a disease state, whereas physiology is the biological discipline that describes processes or mechanisms operating within an organism. Pathology describes the abnormal or undesired condition, whereas pathophysiology seeks to explain the functional changes that are occurring within an individual due to a disease or pathologic state.
Ernest William Goodpasture was an American pathologist and physician. Goodpasture advanced the scientific understanding of the pathogenesis of infectious diseases, parasitism, and a variety of rickettsial and viral infections. Together with colleagues at Vanderbilt University, he invented methods for growing viruses and rickettsiae in chicken embryos and fertilized chicken eggs. This enabled the development of vaccines against influenza, chicken pox, smallpox, yellow fever, typhus, Rocky mountain spotted fever, and other diseases. He also described Goodpasture syndrome.
Stanley "Stan" Falkow was an American microbiologist and a professor of microbiology at Georgetown University, University of Washington, and Stanford University School of Medicine. Falkow is known as the father of the field of molecular microbial pathogenesis. He formulated molecular Koch's postulates, which have guided the study of the microbial determinants of infectious diseases since the late 1980s. Falkow spent over 50 years uncovering molecular mechanisms of how bacteria cause disease and how to disarm them. Falkow also was one of the first scientists to investigate antimicrobial resistance, and presented his research extensively to scientific, government, and lay audiences explaining the spread of resistance from one organism to another, now known as horizontal gene transfer, and the implications of this phenomenon on our ability to combat infections in the future.
Clinical pathology is a medical specialty that is concerned with the diagnosis of disease based on the laboratory analysis of bodily fluids, such as blood, urine, and tissue homogenates or extracts using the tools of chemistry, microbiology, hematology, molecular pathology, and Immunohaematology. This specialty requires a medical residency.
Marilyn Gist Farquhar was a pathologist and cellular biologist, Professor of Cellular and Molecular Medicine and Pathology, as well as the chair of the Department of Cellular and Molecular Medicine at the University of California, San Diego School of Medicine, who previously worked at Yale University from 1973 to 1990. She has won the E. B. Wilson Medal and the FASEB Excellence in Science Award. She was married to Nobel Laureate George Emil Palade from 1970 to his death in 2008. Her research focuses on control of intracellular membrane traffic and the molecular pathogenesis of auto immune kidney diseases. She has yielded a number of discoveries in basic biomedical research including: mechanisms of kidney disease, organization of functions that attach cells to one another, and mechanisms of secretions.
Mark Anthony Smith was a professor of pathology at Case Western Reserve University in Cleveland, Ohio, where he also served as the Director of Basic Science Research at the University Memory and Aging Center. At the time of his death, he had been serving as Executive Director of the American Aging Association.
The Federation of American Societies for Experimental Biology (FASEB), based in Rockville, Maryland, is a non-profit organization of scientific societies in the United States. With a focus on the biological and biomedical sciences, the federation represents scientists in such fields as anatomy, physiology, immunology, biochemistry, molecular biology, toxicology, genetics, and nutrition.
The American Association of Pathologists and Bacteriologists (AAPB) was an American national professional association established in 1901, devoted to fundamental science and academic medicine as distinct from clinical medicine. In 1976, they joined with the American Society for Experimental Pathology (ASEP) to form the American Association of Pathologists (AAP), which in 1992 became the American Society for Investigative Pathology (ASIP).
Eugene Lindsay Opie was an American physician and pathologist who conducted research on the causes, transmission, and diagnosis of tuberculosis and on immunization against the disease. He served as professor of pathology at several U.S. medical schools and as Dean of the Washington University School of Medicine.
The Histochemical Society (HCS) is an academic society that was founded on March 24, 1950 at a meeting organized by Ralph D. Lillie of the National Institutes of Health. The idea for the Society arose during the 1949 Biological Stain Commission meeting at which a symposia encompassing anatomy, cytology, pathology and biochemistry was proposed by Lillie, Charles Leblond and Edward Dempsey. Lillie became the first editor of HCS's journal, Journal of Histochemistry and Cytochemistry.
Abul K. Abbas is an American pathologist at University of California San Francisco where he is Distinguished Professor in Pathology and former chair of its Department of Pathology. He is senior editor of the pathology reference book Robbins and Cotran Pathologic Basis of Disease along with Vinay Kumar, as well as Basic Immunology, and Cellular & Molecular Immunology. He was editor for Immunity from 1993 to 1996, and continues to serve as a member of the editorial board. He was one of the inaugural co-editors of the Annual Review of Pathology: Mechanisms of Disease for issues from 2006 to 2020. He has published nearly 200 scientific papers.
Ramzi S. Cotran (1932-2000) was a pathologist and former president of the United States and Canadian Academy of Pathology (USCAP) and the American Society for Investigative Pathology (ASIP). He was chair of pathology at Harvard's Brigham and Women's Hospital and Children's Hospital Medical Center, as well as the Frank B. Mallory Professor of Pathology at Harvard Medical School and a member of the National Academy of Science's Institute of Medicine. The Ramzi Cotran Young Investigator Award is presented each year by USCAP to a pathologist in recognition of a body of investigative work which has contributed significantly to the diagnosis and understanding of human disease. The ASIP Cotran Early Career Investigator Award is presented each year by ASIP, and recognizes early career investigators who direct independent experimental pathology research programs that are focused on improvement of the understanding of the conceptual basis of disease.
George K. Michalopoulos is a Greek-American pathologist and academic. He served as Maud L. Menten Professor of Experimental Pathology and Chair of the Department of Pathology at the University of Pittsburgh and UPMC from 1991 to 2023.
EmanuelRubin was an American pathologist known for his contributions to the study of liver disease, cardiomyopathy and alcoholic tissue injury, and as the editor of Rubin’s Pathology, a medical textbook first published in 1988, now in its eighth edition.
Paul Roberts Cannon was an American physician and medical professor. He was a pioneer in the study of nutritional effects on immune response.
Peter Maxwell Howley is an American pathologist, virologist, and professor at Harvard Medical School. He has been president of the American Society for Virology and the American Society for Investigative Pathology and a co-editor of the Annual Review of Pathology: Mechanisms of Disease.
Stephen Joseph Galli is an American pathologist who researches mast cells and basophils. He is a member of the National Academy of Medicine, a recipient of the National Institutes of Health MERIT Award, and former co-editor of the Annual Review of Pathology: Mechanisms of Disease.
The Association for Molecular Pathology is a professional association of individuals serving patients through molecular diagnostics testing. Founded in 1995, the Association has more than 2,800 members in over 50 countries.
References
- ↑ "American Society for Investigative Pathology - Mission and History". ASIP.org. Retrieved 2014-08-22.
- ↑ American Society for Investigative Pathology (2018), An Executive Summary of the History of ASEP and Its Successors, archived from the original on 2018-06-30, retrieved 2018-06-30.
- ↑ ASIP Gold-Headed Cane Award, ASIP, retrieved 2024-02-24
- ↑ Awards & Honors, ASIP, retrieved 2024-02-24
- ↑ "The American Journal of Pathology Home Page". ajp.amjpathol.org.
- ↑ "The Journal of Molecular Diagnostics Home Page". jmd.amjpathol.org.
- ↑ "American Society for Investigative Pathology". ASIP.org. Retrieved 2014-08-22.
