Amikhelline

Amikhelline
Clinical data
ATC code	none;
Pharmacokinetic data
Metabolism	none
Identifiers
	IUPAC name 9-(2-diethylaminoethoxy)-4-hydroxy-7-methylpyrano[3,2-f][1]benzoxol-5-one;
CAS Number	4439-67-2 ;
PubChem CID	71198 ;
ChemSpider	64334 ;
UNII	BD9T227F6M ;
ChEMBL	ChEMBL2104025 ;
CompTox Dashboard (EPA)	DTXSID20196151 ;
Chemical and physical data
Formula	C18H21NO5
Molar mass	331.368 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=C/1c3c(O\C(=C\1)C)c(OCCN(CC)CC)c2occc2c3O;
	InChI InChI=1S/C18H21NO5/c1-4-19(5-2)7-9-23-18-16-12(6-8-22-16)15(21)14-13(20)10-11(3)24-17(14)18/h6,8,10,21H,4-5,7,9H2,1-3H3 ; Key:QZBPFSZZMYTRIA-UHFFFAOYSA-N ;
	(verify)

Last updated April 12, 2023

Amikhelline is an antimitotic drug.^[1] It acts as a DNA intercalator ^[2] and inhibits DNA polymerase.^[3]

Related Research Articles

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<span class="mw-page-title-main">SECIS element</span> RNA sequence directing the translation of UGA codons as selenocysteines

In biology, the SECIS element is an RNA element around 60 nucleotides in length that adopts a stem-loop structure. This structural motif directs the cell to translate UGA codons as selenocysteines. SECIS elements are thus a fundamental aspect of messenger RNAs encoding selenoproteins, proteins that include one or more selenocysteine residues.

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fis is an E. coli gene encoding the Fis protein. The regulation of this gene is more complex than most other genes in the E. coli genome, as Fis is an important protein which regulates expression of other genes. It is supposed that fis is regulated by H-NS, IHF and CRP. It also regulates its own expression (autoregulation). Fis is one of the most abundant DNA binding proteins in Escherichia coli under nutrient-rich growth conditions.

<span class="mw-page-title-main">Small nucleolar RNA SNORA71</span>

In molecular biology, U71 belongs to the H/ACA class of Small nucleolar RNA (snoRNAs). snoRNAs bind a number of proteins to form snoRNP complexes. This class are thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs. Targets may include ribosomal and spliceosomal RNAs but the exact function of many snoRNAs, including U71, is unclear.

<span class="mw-page-title-main">Small nucleolar RNA SNORA75</span> RNA type

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References

↑ Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP (1985). "[Characterization of chromosomal aberrations induced in man by various antimitotic agents]". Comptes Rendus des Séances de la Société de Biologie et de ses Filiales. 179 (3): 331–9. PMID 2417673.
↑ Rucheton M, Jeanteur P (1973). "Studies on amikhellin. I. Intercalative binding to double-stranded DNA". Biochimie. 55 (11): 1415–20. doi:10.1016/s0300-9084(74)80548-1. PMID 4364376.
↑ Rucheton M, Jeanteur P (1976). "Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus". Biochimie. 58 (6): 689–95. doi:10.1016/s0300-9084(76)80393-8. PMID 60141.

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[1] Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP (1985). "[Characterization of chromosomal aberrations induced in man by various antimitotic agents]". Comptes Rendus des Séances de la Société de Biologie et de ses Filiales. 179 (3): 331–9. PMID 2417673.

[2] Rucheton M, Jeanteur P (1973). "Studies on amikhellin. I. Intercalative binding to double-stranded DNA". Biochimie. 55 (11): 1415–20. doi:10.1016/s0300-9084(74)80548-1. PMID 4364376.

[3] Rucheton M, Jeanteur P (1976). "Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus". Biochimie. 58 (6): 689–95. doi:10.1016/s0300-9084(76)80393-8. PMID 60141.

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