Aminometradine

Last updated
Aminometradine
Aminometradine.png
Clinical data
ATC code
  • none
Identifiers
  • 6-Amino-3-ethyl-1-prop-2-enylpyrimidine-2,4-dione
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.010.350 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C9H13N3O2
Molar mass 195.222 g·mol−1
3D model (JSmol)
  • O=C1N(/C(=C\C(=O)N1CC)N)C\C=C
  • InChI=1S/C9H13N3O2/c1-3-5-12-7(10)6-8(13)11(4-2)9(12)14/h3,6H,1,4-5,10H2,2H3 Yes check.svgY
  • Key:NGXUUAFYUCOICP-UHFFFAOYSA-N Yes check.svgY
   (verify)

Aminometradine (sold as Mictine and Mincard, among others) is a weak diuretic which was used to control oedema in those who suffered mild congestive heart failure. [1]

Alkyl uracil derivatives have been known for some time to act as diuretic agents in experimental animals. The toxicity of these agents precluded their use in the clinic. Appropriate modification of the molecule, did, however yield diuretic agents in man.

References

  1. ↑ Platts MM, Hanley T (May 1956). "Aminometradine in treatment of congestive heart failure". British Medical Journal. 1 (4975): 1078–80. doi:10.1136/bmj.1.4975.1078. PMC   1979900 . PMID   13316073.
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