Angiopoietin-related protein 1

ANGPTL1
Identifiers
Aliases	ANGPTL1 , ANG3, ANGPT3, ARP1, AngY, UNQ162, dJ595C2.2, angiopoietin like 1
External IDs	OMIM: 603874 MGI: 1919963 HomoloGene: 128467 GeneCards: ANGPTL1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	178,871,077 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	156,688,648 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; smooth muscle tissue; ; Achilles tendon; ; popliteal artery; ; left coronary artery; ; synovial membrane; ; synovial joint; ; pancreatic epithelial cell; ; gastric mucosa; ; right coronary artery;
	Top expressed in
	basilar part of occipital bone; ; intercostal muscle; ; squamous epithelium; ; condyle; ; mesothelium; ; rib; ; sphenoid bone; ; dermis; ; lesser wing of sphenoid bone; ; soleus muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	signaling receptor binding ;
Cellular component	extracellular exosome ; extracellular region ; extracellular space ;
Biological process	transmembrane receptor protein tyrosine kinase signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	9068
	72713
	ENSG00000116194
	ENSMUSG00000033544
	O95841
	Q640P2
	NM_004673 ; NM_001376763
	NM_028333
	NP_004664 ; NP_001363692
	NP_082609
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 26, 2024

Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene.^[5]^[6]^[7]

Function

Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels.

The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro.^[7]

Related Research Articles

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.

Angiopoietin-1 receptor also known as CD202B is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor.

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P₂, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

Chemokine-binding protein 2 is a protein that in humans is encoded by the CCBP2 gene.

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein that in humans is encoded by the LPAR3 gene. LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">ADAMTS1</span> Protein-coding gene in the species Homo sapiens

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.

Junctional adhesion molecule C is a protein that in humans is encoded by the JAM3 gene.

Chloride intracellular channel 4, also known as CLIC4,p644H1,HuH1, is a eukaryotic gene.

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322.

Sulfhydryl oxidase 1 is an enzyme that in humans is encoded by the QSOX1 gene.

Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene. VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member.

<span class="mw-page-title-main">ANGPTL3</span> Protein-coding gene in the species Homo sapiens

Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene.

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.

Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene.

Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.

Apolipoprotein F is a protein that in humans is encoded for by the APOF gene. The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116194 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033544 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999). "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett. 443 (3): 353–6. doi: 10.1016/S0014-5793(99)00008-3 . PMID 10025962. S2CID 27230019.
↑ Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics. 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704.
1 2 "Entrez Gene: ANGPTL1 angiopoietin-like 1".

External links

Human ANGPTL1 genome location and ANGPTL1 gene details page in the UCSC Genome Browser .

Dhanabal M, Jeffers M, LaRochelle WJ, Lichenstein HS (2005). "Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties". Biochem. Biophys. Res. Commun. 333 (2): 308–15. doi:10.1016/j.bbrc.2005.05.134. PMID 15950186.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. Bibcode:1999PNAS...96.1904V. doi: 10.1073/pnas.96.5.1904 . PMC 26709 . PMID 10051567.
Avram D, Ishmael JE, Nevrivy DJ, et al. (1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". J. Biol. Chem. 274 (20): 14331–6. doi: 10.1074/jbc.274.20.14331 . PMC 2823254 . PMID 10318855.
Kim I, Moon SO, Koh KN, et al. (1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J. Biol. Chem. 274 (37): 26523–8. doi: 10.1074/jbc.274.37.26523 . PMID 10473614.
Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi: 10.1007/s100380300025 . PMID 12624729.
Lee HJ, Cho CH, Hwang SJ, et al. (2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200–8. doi: 10.1096/fj.03-1466com . PMID 15284220. S2CID 19001234.
Oliner J, Min H, Leal J, et al. (2004). "Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2". Cancer Cell. 6 (5): 507–16. doi: 10.1016/j.ccr.2004.09.030 . PMID 15542434.
Smagur A, Szary J, Szala S (2006). "Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours". Acta Biochim. Pol. 52 (4): 875–9. doi: 10.18388/abp.2005_3401 . PMID 15940350.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116194 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033544 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10025962-5] Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999). "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett. 443 (3): 353–6. doi: 10.1016/S0014-5793(99)00008-3 . PMID 10025962. S2CID 27230019.

[pmid9286704-6] Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics. 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704.

[entrez-7] 1 2 "Entrez Gene: ANGPTL1 angiopoietin-like 1".

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Angiopoietin-related protein 1

Contents

Function

Related Research Articles

References

External links

Further reading