Annexin A3

Last updated
ANXA3
Protein ANXA3 PDB 1aii.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ANXA3 , ANX3, annexin A3
External IDs OMIM: 106490; MGI: 1201378; HomoloGene: 68445; GeneCards: ANXA3; OMA:ANXA3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005139

NM_013470

RefSeq (protein)

NP_005130

NP_038498

Location (UCSC) Chr 4: 78.55 – 78.61 Mb Chr 5: 96.94 – 96.99 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene. [5] [6]

Contents

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. [7]

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138772 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029484 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM (Aug 1991). "Chromosomal localization of the human annexin III (ANX3) gene". Genomics. 10 (2): 441–8. doi:10.1016/0888-7543(91)90330-H. PMID   1830024.
  6. 1 2 "Entrez Gene: ANXA3 annexin A3".
  7. Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics. 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID   18792929. S2CID   206362532.

Further reading