Annexin A3

Last updated
ANXA3
Protein ANXA3 PDB 1aii.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ANXA3 , ANX3, annexin A3
External IDs OMIM: 106490 MGI: 1201378 HomoloGene: 68445 GeneCards: ANXA3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005139

NM_013470

RefSeq (protein)

NP_005130

NP_038498

Location (UCSC) Chr 4: 78.55 – 78.61 Mb Chr 5: 96.94 – 96.99 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene. [5] [6]

Contents

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. [7]

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [6]

Related Research Articles

Annexin

Annexin is a common name for a group of cellular proteins. They are mostly found in eukaryotic organisms.

Annexin A1

Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans.

Annexin A2

Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene.

Annexin A5 Protein-coding gene in the species Homo sapiens

Annexin A5 is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane. The function of the protein is unknown; however, annexin A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. These properties have been found by in vitro experiments.

Annexin A6

Annexin A6 is a protein that in humans is encoded by the ANXA6 gene.

In enzymology, a glycerophosphoinositol inositolphosphodiesterase (EC 3.1.4.43) is an enzyme that catalyzes the chemical reaction

Annexin A4

Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.

Annexin A7 Protein-coding gene in the species Homo sapiens

Annexin A7 is a protein that in humans is encoded by the ANXA7 gene.

Annexin A11 Protein-coding gene in the species Homo sapiens

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.

PPAP2A

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.

60S ribosomal protein L4

60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene.

ANXA8L2

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.

ALG2

Alpha-1,3/1,6-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene. Mutations in the human gene are associated with congenital defects in glycosylation The protein encoded by the ALG2 gene belongs to two classes of enzymes: GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase and GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase.

INPP4A

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene.

ITPK1

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.

IHPK1

Inositol hexakisphosphate kinase 1 is an enzyme that in humans is encoded by the IP6K1 gene.

NUDT3

Diphosphoinositol polyphosphate phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene.

Annexin A13

Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.

Annexin A9

Annexin A9 is a protein that in humans is encoded by the ANXA9 gene.

2,3-Cyclic-nucleotide 3-phosphodiesterase

2',3'-Cyclic-nucleotide 3'-phosphodiesterase also known as CNPase is an enzyme that in humans is encoded by the CNP gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138772 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029484 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM (Aug 1991). "Chromosomal localization of the human annexin III (ANX3) gene". Genomics. 10 (2): 441–8. doi:10.1016/0888-7543(91)90330-H. PMID   1830024.
  6. 1 2 "Entrez Gene: ANXA3 annexin A3".
  7. Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics. 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID   18792929. S2CID   206362532.

Further reading