Annexin A4

ANXA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ZOC
Identifiers
Aliases	ANXA4 , ANX4, HEL-S-274, PIG28, ZAP36, P32.5, PAP-II, PP4-X, annexin A4
External IDs	OMIM: 106491 MGI: 88030 HomoloGene: 68164 GeneCards: ANXA4
Gene location (Human)
Chr.	Chromosome 2 (human)
End	69,827,112 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	86,770,566 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; gallbladder; ; jejunal mucosa; ; duodenum; ; body of pancreas; ; islet of Langerhans; ; bronchial epithelial cell; ; germinal epithelium; ; visceral pleura; ; Achilles tendon;
	Top expressed in
	Paneth cell; ; jejunum; ; crypt of lieberkuhn of small intestine; ; gastric mucosa; ; epithelium of stomach; ; ileum; ; pyloric antrum; ; mucous cell of stomach; ; intestinal villus; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phospholipase inhibitor activity ; calcium ion binding ; calcium-dependent protein binding ; NF-kappaB binding ; protein binding ; identical protein binding ; calcium-dependent phospholipid binding ; heparin binding ; chondroitin sulfate binding ;
Cellular component	cytoplasm ; nuclear membrane ; vesicle membrane ; plasma membrane ; cell surface ; perinuclear region of cytoplasm ; extracellular exosome ; nucleus ; cytosol ; collagen-containing extracellular matrix ;
Biological process	Notch signaling pathway ; epithelial cell differentiation ; regulation of transcription by RNA polymerase II ; negative regulation of apoptotic process ; negative regulation of NF-kappaB transcription factor activity ; signal transduction ; negative regulation of catalytic activity ;
	Sources:Amigo / QuickGO
Orthologs
	307
	11746
	ENSG00000196975
	ENSMUSG00000029994
	P09525
	P97429
	NM_001153 ; NM_001320698 ; NM_001320700 ; NM_001320702 ; NM_001365496 Contents Function ; References ; External links ; Further reading ;
	NM_013471 ; NM_001331120
	NP_001144 ; NP_001307627 ; NP_001307629 ; NP_001307631 ; NP_001352425
	NP_001318049 ; NP_038499
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 24, 2023

Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.^[5]^[6]

Function

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.^[6]

Related Research Articles

<span class="mw-page-title-main">Annexin</span> Protein family

Annexin is a common name for a group of cellular proteins. They are mostly found in eukaryotic organisms.

Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans.

Annexin A2 also known as annexin II is a protein founded by Dr. Baogang Xu, that in humans is encoded by the ANXA2 gene.

Annexin A5 is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane. The function of the protein is unknown; however, annexin A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. These properties have been found by in vitro experiments.

Heat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen.

Caveolin-1 is a protein that in humans is encoded by the CAV1 gene.

Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.

Annexin A6 is a protein that in humans is encoded by the ANXA6 gene.

Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene.

Testicular receptor 4 also known as NR2C2 is a protein that in humans is encoded by the NR2C2 gene.

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene. SOCS1 orthologs have been identified in several mammals for which complete genome data are available.

S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein that is encoded by the S100A10 gene in humans and the S100a10 gene in other species. S100A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells. They regulate a number of cellular processes such as cell cycle progression and differentiation. The S100 protein is implicated in exocytosis and endocytosis by reorganization of F-actin.

Sorcin is a protein that in humans is encoded by the SRI gene.

Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene.

Annexin A7 is a protein that in humans is encoded by the ANXA7 gene.

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene.

Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene.

Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.

Annexin A9 is a protein that in humans is encoded by the ANXA9 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196975 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029994 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tait JF, Smith C, Frankenberry DA, Miao CH, Adler DA, Disteche CM (Feb 1992). "Chromosomal mapping of the human annexin IV (ANX4) gene". Genomics. 12 (2): 313–8. doi:10.1016/0888-7543(92)90379-7. PMID 1346776.
1 2 "Entrez Gene: ANXA4 annexin A4".

External links

Human ANXA4 genome location and ANXA4 gene details page in the UCSC Genome Browser .

Römisch J, Heimburger N (May 1990). "Purification and characterization of six annexins from human placenta". Biological Chemistry Hoppe-Seyler. 371 (5): 383–8. doi:10.1515/bchm3.1990.371.1.383. PMID 2143074.
Römisch J, Grote M, Weithmann KU, Heimburger N, Amann E (Nov 1990). "Annexin proteins PP4 and PP4-X. Comparative characterization of biological activities of placental and recombinant proteins". The Biochemical Journal. 272 (1): 223–9. doi:10.1042/bj2720223. PMC 1149680 . PMID 2148260.
Freemont PS, Driessen HP, Verbi W, Crumpton MJ (Nov 1990). "Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV". Journal of Molecular Biology. 216 (2): 219–21. doi:10.1016/S0022-2836(05)80310-9. PMID 2254922.
Hauptmann R, Maurer-Fogy I, Krystek E, Bodo G, Andree H, Reutelingsperger CP (Oct 1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". European Journal of Biochemistry. 185 (1): 63–71. doi: 10.1111/j.1432-1033.1989.tb15082.x . PMID 2530088.
Grundmann U, Amann E, Abel KJ, Küpper HA (Apr 1988). "Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family". Behring Institute Mitteilungen (82): 59–67. PMID 2970257.
Ahn NG, Teller DC, Bienkowski MJ, McMullen BA, Lipkin EW, de Haën C (Dec 1988). "Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor". The Journal of Biological Chemistry. 263 (35): 18657–63. doi: 10.1016/S0021-9258(18)37335-6 . PMID 2974032.
Tait JF, Sakata M, McMullen BA, Miao CH, Funakoshi T, Hendrickson LE, Fujikawa K (Aug 1988). "Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family". Biochemistry. 27 (17): 6268–76. doi:10.1021/bi00417a011. PMID 2975506.
Sjölin C, Stendahl O, Dahlgren C (Jun 1994). "Calcium-induced translocation of annexins to subcellular organelles of human neutrophils". The Biochemical Journal. 300 ( Pt 2) (Pt 2): 325–30. doi:10.1042/bj3000325. PMC 1138165 . PMID 8002935.
Kojima K, Yamamoto K, Irimura T, Osawa T, Ogawa H, Matsumoto I (Mar 1996). "Characterization of carbohydrate-binding protein p33/41: relation with annexin IV, molecular basis of the doublet forms (p33 and p41), and modulation of the carbohydrate binding activity by phospholipids". The Journal of Biological Chemistry. 271 (13): 7679–85. doi: 10.1074/jbc.271.13.7679 . PMID 8631806.
Davis AJ, Butt JT, Walker JH, Moss SE, Gawler DJ (Oct 1996). "The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP". The Journal of Biological Chemistry. 271 (40): 24333–6. doi: 10.1074/jbc.271.40.24333 . PMID 8798684.
Satoh A, Takayama E, Kojima K, Ogawa H, Yamori T, Sato S, Kawaguchi T, Tsuruo T, Katsura Y, Kina T, Matsumoto I (Feb 1996). "Expression of carbohydrate-binding protein p33/41 in human tumor cell lines". Journal of Biochemistry. 119 (2): 346–53. doi:10.1093/oxfordjournals.jbchem.a021246. PMID 8882729.
Satoh A, Takayama E, Kojima K, Ogawa H, Katsura Y, Kina T, Matsumoto I (Mar 1997). "Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17". Biological & Pharmaceutical Bulletin. 20 (3): 224–9. doi: 10.1248/bpb.20.224 . PMID 9084877.
Dreier R, Schmid KW, Gerke V, Riehemann K (Aug 1998). "Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study". Histochemistry and Cell Biology. 110 (2): 137–48. doi:10.1007/s004180050275. PMID 9720986. S2CID 19597353.
Chow A, Davis AJ, Gawler DJ (Mar 2000). "Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain". FEBS Letters. 469 (1): 88–92. doi: 10.1016/S0014-5793(00)01252-7 . PMID 10708762. S2CID 21394463.
Han EK, Tahir SK, Cherian SP, Collins N, Ng SC (Jul 2000). "Modulation of paclitaxel resistance by annexin IV in human cancer cell lines". British Journal of Cancer. 83 (1): 83–8. doi:10.1054/bjoc.2000.1311. PMC 2374538 . PMID 10883672.
Radau B, Otto A, Müller EC, Westermann P (Jul 2000). "Protein kinase C alpha-dependent phosphorylation of Golgi proteins". Electrophoresis. 21 (13): 2684–7. doi:10.1002/1522-2683(20000701)21:13<2684::AID-ELPS2684>3.0.CO;2-G. PMID 10949146. S2CID 84800747.
Gerner C, Frohwein U, Gotzmann J, Bayer E, Gelbmann D, Bursch W, Schulte-Hermann R (Dec 2000). "The Fas-induced apoptosis analyzed by high throughput proteome analysis". The Journal of Biological Chemistry. 275 (50): 39018–26. doi: 10.1074/jbc.M006495200 . PMID 10978337.
Tsujii-Hayashi Y, Kitahara M, Yamagaki T, Kojima-Aikawa K, Matsumoto I (Dec 2002). "A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes". The Journal of Biological Chemistry. 277 (49): 47493–9. doi: 10.1074/jbc.M206572200 . PMID 12324456.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196975 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029994 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1346776-5] Tait JF, Smith C, Frankenberry DA, Miao CH, Adler DA, Disteche CM (Feb 1992). "Chromosomal mapping of the human annexin IV (ANX4) gene". Genomics. 12 (2): 313–8. doi:10.1016/0888-7543(92)90379-7. PMID 1346776.

[entrez-6] 1 2 "Entrez Gene: ANXA4 annexin A4".

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Annexin A4

Contents

Function

Related Research Articles

References

External links

Further reading