Annual pharmaceutical drug sales

Last updated November 18, 2025

This is a list of annual sales of patented medications per pharmaceutical group. Because it derives from 10-K data, drugs that have passed loss of exclusivity (LOE) will cease to be on this list.

Annual Sales (2020-present)

Medication	Trade name	Primary Indication	Company
atorvastatin	Lipitor	Reduction of LDL cholesterol	Pfizer
sunitinib malate	Sutent	Advanced and/or metastatic renal cell carcinoma (mRCC) & refractory gastrointestinal stromal tumors (GIST)	Pfizer
irinotecan	Camptosar	Metastatic colorectal cancer	Pfizer
bimatoprost	Lumigan	Open-angle glaucoma or ocular hypertension	Allergan
exemestane	Aromasin	Breast cancer	Pfizer
epirubicin	Ellence	Breast cancer	Pfizer
trastuzumab	Herceptin	HER2-positive metastatic breast cancer	Genentech
gemcitabine	Gemzar	Ovarian cancer, non-small cell lung cancer (NSCLC), metastatic breast cancer (MBC), and pancreatic cancer	Eli Lilly & Co.
bevacizumab	Avastin	Metastatic colorectal cancer, non-small cell lung cancer (NSCLC), renal cell carcinoma, HER2-negative breast cancer	Genentech
erlotinib	Tarceva	Advanced (metastatic) non-small cell lung cancer (NSCLC)	Genentech
brimonidine	Alphagan	Open-angle glaucoma or ocular hypertension	Allergan
rituximab	Rituxan	Non-Hodgkin's lymphoma and rheumatoid arthritis	Genentech
ranibizumab	Lucentis	Age-related macular degeneration (AMD)	Genentech
omalizumab	Xolair	Asthma	Genentech
somatropin	Nutropin	Growth hormone deficiency, chronic kidney disease	Genentech
dornase alfa	Pulmozyme	Cystic fibrosis (CF)	Genentech
efalizumab	Raptiva	Plaque psoriasis	Genentech
montelukast	Singulair	Asthma	Merck
alendronate sodium	Fosamax	Postmenopausal osteoporosis	Merck
sitagliptin	Januvia	Type 2 diabetes	Merck
simvastatin	Zocor	Reduction of LDL cholesterol	Merck
rizatriptan benzoate	Maxalt	Migraine pain	Merck
finasteride	Propecia	Hair loss	Merck
etoricoxib	Arcoxia	Osteoarthritis and rheumatoid arthritis	Merck
sitagliptin/metformin HCl	Janumet	Type 2 diabetes	Merck
finasteride	Proscar	Benign prostatic hyperplasia (enlarged prostate)	Merck
aprepitant	Emend	Nausea and vomiting prevention caused by chemotherapy	Merck
olanzapine	Zyprexa	Schizophrenia	Eli Lilly & Co.
duloxetine HCl	Cymbalta	Depression and generalized anxiety disorder	Eli Lilly & Co.
insulin lispro	Humalog	Type 1 diabetes in adults	Eli Lilly & Co.
pemetrexed	Alimta	Locally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC)	Eli Lilly & Co.
raloxifene HCl	Evista	Osteoporosis	Eli Lilly & Co.
insulin isophane	Humulin	Diabetes	Eli Lilly & Co.
teriparatide	Forteo	Osteoporosis	Eli Lilly & Co.
atomoxetine HCl	Strattera	Attention-deficit/hyperactivity disorder (ADHD)	Eli Lilly & Co.
timolol	Istalol	Open-angle glaucoma	Ista Pharmaceutical
bromfenac	Xibrom	Ocular inflammation	Ista Pharmaceutical
hyaluronidase	Vitrase	Spreading agent	Ista Pharmaceutica
rivaroxaban	Xarelto	Deep vein thrombosis	Johnson & Johnson ^[1]

Annual Sales (2010-2020)

Medication	Trade name	Primary Indication	Company
atorvastatin	Lipitor	Reduction of LDL cholesterol	Pfizer	2020	2019	2018	2017	2016	2015	2014	2013	2012	2011	2010
sunitinib malate	Sutent	Advanced and/or metastatic renal cell carcinoma (mRCC) & refractory gastrointestinal stromal tumors (GIST)	Pfizer
irinotecan	Camptosar	Metastatic colorectal cancer	Pfizer
bimatoprost	Lumigan	Open-angle glaucoma or ocular hypertension	Allergan
exemestane	Aromasin	Breast cancer	Pfizer
epirubicin	Ellence	Breast cancer	Pfizer
trastuzumab	Herceptin	HER2-positive metastatic breast cancer	Genentech
gemcitabine	Gemzar	Ovarian cancer, non-small cell lung cancer (NSCLC), metastatic breast cancer (MBC), and pancreatic cancer	Eli Lilly & Co.
bevacizumab	Avastin	Metastatic colorectal cancer, non-small cell lung cancer (NSCLC), renal cell carcinoma, HER2-negative breast cancer	Genentech
erlotinib	Tarceva	Advanced (metastatic) non-small cell lung cancer (NSCLC)	Genentech
brimonidine	Alphagan	Open-angle glaucoma or ocular hypertension	Allergan
rituximab	Rituxan	Non-Hodgkin's lymphoma and rheumatoid arthritis	Genentech
ranibizumab	Lucentis	Age-related macular degeneration (AMD)	Genentech
omalizumab	Xolair	Asthma	Genentech
somatropin	Nutropin	Growth hormone deficiency, chronic kidney disease	Genentech
dornase alfa	Pulmozyme	Cystic fibrosis (CF)	Genentech
efalizumab	Raptiva	Plaque psoriasis	Genentech
montelukast	Singulair	Asthma	Merck
alendronate sodium	Fosamax	Postmenopausal osteoporosis	Merck
sitagliptin	Januvia	Type 2 diabetes	Merck
simvastatin	Zocor	Reduction of LDL cholesterol	Merck
rizatriptan benzoate	Maxalt	Migraine pain	Merck
finasteride	Propecia	Hair loss	Merck
etoricoxib	Arcoxia	Osteoarthritis and rheumatoid arthritis	Merck
sitagliptin/metformin HCl	Janumet	Type 2 diabetes	Merck
finasteride	Proscar	Benign prostatic hyperplasia (enlarged prostate)	Merck
aprepitant	Emend	Nausea and vomiting prevention caused by chemotherapy	Merck
olanzapine	Zyprexa	Schizophrenia	Eli Lilly & Co.
duloxetine HCl	Cymbalta	Depression and generalized anxiety disorder	Eli Lilly & Co.
insulin lispro	Humalog	Type 1 diabetes in adults	Eli Lilly & Co.
pemetrexed	Alimta	Locally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC)	Eli Lilly & Co.
raloxifene HCl	Evista	Osteoporosis	Eli Lilly & Co.
insulin isophane	Humulin	Diabetes	Eli Lilly & Co.
teriparatide	Forteo	Osteoporosis	Eli Lilly & Co.
atomoxetine HCl	Strattera	Attention-deficit/hyperactivity disorder (ADHD)	Eli Lilly & Co.
timolol	Istalol	Open-angle glaucoma	Ista Pharmaceutical
bromfenac	Xibrom	Ocular inflammation	Ista Pharmaceutical
hyaluronidase	Vitrase	Spreading agent	Ista Pharmaceutica
rivaroxaban	Xarelto	Deep vein thrombosis	Johnson & Johnson ^[1]

Annual Sales (2000-2010)

Medication	Trade name	Primary Indication	Company	2010	2009	2008^[2]^[3]^[4]^[5]^[6]^[7]	2007^[8]^[9]^[10]^[11]^[12]^[13]	2006^[14]^[15]^[16]^[17]^[18]^[19]	2005^[20]^[21]^[22]^[23]^[24]	2004^[25]^[26]^[27]^[28]	2003^[29]^[30]^[31]^[32]	2002^[33]^[34]^[35]^[36]	2001^[37]	2000^[38]^[39]
atorvastatin	Lipitor	Reduction of LDL cholesterol	Pfizer			$12,401	$12,675	$12,886	$12,187	$10,862	$9,231	$7,972	$6,448	$5,028
sunitinib malate	Sutent	Advanced and/or metastatic renal cell carcinoma (mRCC) & refractory gastrointestinal stromal tumors (GIST)	Pfizer			$847	$581	$219
irinotecan	Camptosar	Metastatic colorectal cancer	Pfizer			$563	$969	$903	$910	$554	$299
bimatoprost	Lumigan	Open-angle glaucoma or ocular hypertension	Allergan			$426.2	$391.7	$327.5	$267.6	$232.9	$181.3	$123	$35.4
exemestane	Aromasin	Breast cancer	Pfizer			$465	$401	$320	$247	$143	$58
epirubicin	Ellence	Breast cancer	Pfizer					$312	$367	$344	$216
trastuzumab	Herceptin	HER2-positive metastatic breast cancer	Genentech			$1,382	$1,287	$1,234	$747.2	$483.2	$424.8	$385.2	$346.7	$276
gemcitabine	Gemzar	Ovarian cancer, non-small cell lung cancer (NSCLC), metastatic breast cancer (MBC), and pancreatic cancer	Eli Lilly & Co.			$1,719.8	$1,592.4	$1,408.1	$1,334.5	$1,214.4	$1,021.7	$875	$723	$559.3
bevacizumab	Avastin	Metastatic colorectal cancer, non-small cell lung cancer (NSCLC), renal cell carcinoma, HER2-negative breast cancer	Genentech			$2,686	$2,296	$1,746	$1,132	$554.6
erlotinib	Tarceva	Advanced (metastatic) non-small cell lung cancer (NSCLC)	Genentech			$457	$417	$402	$274.9	$13.3
brimonidine	Alphagan	Open-angle glaucoma or ocular hypertension	Allergan								$286.8	$248.5	$250.9
rituximab	Rituxan	Non-Hodgkin's lymphoma and rheumatoid arthritis	Genentech			$2,587	$2,285	$2,071	$1,831.4	$1,574	$1,360.2	$1,162.9	$818.6
ranibizumab	Lucentis	Age-related macular degeneration (AMD)	Genentech			$875	$815	$380
omalizumab	Xolair	Asthma	Genentech			$517	$472	$425	$320.6	$187.6	$25.1
somatropin	Nutropin	Growth hormone deficiency, chronic kidney disease	Genentech			$358	$371	$378	$370.5	$348.8	$319.5
dornase alfa	Pulmozyme	Cystic fibrosis (CF)	Genentech			$257	$223	$199	$186.5	$157.1	$143.7	$138.1	$123
efalizumab	Raptiva	Plaque psoriasis	Genentech			$108	$107	$90	$79.2	$52.4	$1.4
montelukast	Singulair	Asthma	Merck			$4,336.9	$4,266.3	$3,579	$2,975.6	$2,622
alendronate sodium	Fosamax	Postmenopausal osteoporosis	Merck			$1,552.7	$3,049	$3,134.4	$3,191.2	$3,159.7
sitagliptin	Januvia	Type 2 diabetes	Merck			$1,397.1	$667.5	$42.9
simvastatin	Zocor	Reduction of LDL cholesterol	Merck			$660.1	$876.5	$2,802.7	$4,381.7	$5,196.5
rizatriptan benzoate	Maxalt	Migraine pain	Merck			$529.2	$467.3	$406.4	$348.4	$309.9
finasteride	Propecia	Hair loss	Merck			$429.1	$405.4	$351.8	$291.9	$270.2
etoricoxib	Arcoxia	Osteoarthritis and rheumatoid arthritis	Merck			$377.3	$329.1	$265.4	$218.2
sitagliptin/metformin HCl	Janumet	Type 2 diabetes	Merck			$351.1	$86.4
finasteride	Proscar	Benign prostatic hyperplasia (enlarged prostate)	Merck			$323.5	$411	$618.5	$741.4	$733.1
aprepitant	Emend	Nausea and vomiting prevention caused by chemotherapy	Merck			$263.8	$204.2	$130.8	$87
olanzapine	Zyprexa	Schizophrenia	Eli Lilly & Co.			$4,696.1	$4,761	$4,363.6	$4,202.3	$4,419.8	$4,276.9	$3,689	$3,087	$2,349.5
duloxetine HCl	Cymbalta	Depression and generalized anxiety disorder	Eli Lilly & Co.			$2,697.1	$2,102.9	$1,316.4	$679.7	$93.9
insulin lispro	Humalog	Type 1 diabetes in adults	Eli Lilly & Co.			$1,735.8	$1,474.6	$1,299.5	$1,197.7	$1,101.6	$1,021.3	$834	$628	$350.2
pemetrexed	Alimta	Locally advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC)	Eli Lilly & Co.			$1,154.7	$854	$611.8	$463.2	$142.6
raloxifene HCl	Evista	Osteoporosis	Eli Lilly & Co.			$1,075.6	$1,090.7	$1,045.3	$1,036.1	$1,012.7	$922.1	$822	$665	$521.5
insulin isophane	Humulin	Diabetes	Eli Lilly & Co.			$1,063.2	$985.2	$925.3	$1,004.7	$997.7	$1,060.4	$1,004	$1,061	$1,114.5
teriparatide	Forteo	Osteoporosis	Eli Lilly & Co.			$778.7	$709.3	$594.3	$389.3	$238.6	$65.3
atomoxetine HCl	Strattera	Attention-deficit/hyperactivity disorder (ADHD)	Eli Lilly & Co.			$579.5	$569.4	$579	$552.1	$666.7	$370.3
timolol	Istalol	Open-angle glaucoma	Ista Pharmaceutical			$14.6	$11.3	$8.3	$2.6
bromfenac	Xibrom	Ocular inflammation	Ista Pharmaceutical			$63	$42.1	$20.2	$5.3
hyaluronidase	Vitrase	Spreading agent	Ista Pharmaceutica			$5.2	$5.2	$4.2	$2.5
rivaroxaban	Xarelto	Deep vein thrombosis	Johnson & Johnson ^[1]	$1,868	$1,522	$864	$239	$25

Notes

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[:0-1] 1 2 3 "SEC Filings - Johnson & Johnson". www.investor.jnj.com. Archived from the original on 2016-04-09. Retrieved 2016-03-25.

[Genentech_2008_10-K-2] , Genentech 2008 10-K.

[Pfizer_2008_10-K-3] , Pfizer 2008 10-K.

[Eli_Lilly_&_Co._2008_10-K-4] , Eli Lilly & Co. 2008 10-K.

[Allergan_2008_10-K-5] , Allergan 2008 10-K.

[Merck_2008_10-K-6] , Merck 2008 10-K.

[Ista_Pharmaceuticals_2008_10-K-7] , Ista Pharmaceuticals 2008 10-K.

[Genentech_2007_10-K-8] , Genentech 2007 10-K.

[Pfizer_2007_10-K-9] , Pfizer 2007 10-K.

[Eli_Lilly_&_Co._2007_10-K-10] , Eli Lilly & Co. 2007 10-K.

[Allergan_2007_10-K-11] , Allergan 2007 10-K.

[Merck_2007_10-K-12] , Merck 2007 10-K.

[Ista_Pharmaceuticals_2007_10-K-13] , Ista Pharmaceuticals 2007 10-K.

[Genentech_2006_10-K-14] , Genentech 2006 10-K.

[Pfizer_2006_10-K-15] , Pfizer 2006 10-K.

[Eli_Lilly_&_Co._2006_10-K-16] , Eli Lilly & Co. 2006 10-K.

[Allergan_2006_10-K-17] , Allergan 2006 10-K.

[Merck_2006_10-K-18] , Merck 2006 10-K.

[Ista_Pharmaceuticals_2006_10-K-19] , Ista Pharmaceuticals 2006 10-K.

[Genentech_2005_10-K-20] , Genentech 2005 10-K.

[Pfizer_2005_10-K-21] , Pfizer 2005 10-K.

[Eli_Lilly_&_Co._2005_10-K-22] , Eli Lilly & Co. 2005 10-K.

[Allergan_2005_10-K-23] , Allergan 2005 10-K.

[Merck_2005_10-K-24] , Merck 2005 10-K.

[Genentech_2004_10-K-25] , Genentech 2004 10-K.

[Pfizer_2004_10-K-26] , Pfizer 2004 10-K.

[Eli_Lilly_&_Co._2004_10-K-27] , Eli Lilly & Co. 2004 10-K.

[Allergan_2004_10-K-28] , Allergan 2004 10-K.

[Genentech_2003_10-K-29] , Genentech 2003 10-K.

[Pfizer_2003_10-K-30] , Pfizer 2003 10-K.

[Eli_Lilly_&_Co._2003_10-K-31] , Eli Lilly & Co. 2003 10-K.

[Allergan_2003_10-K-32] , Allergan 2003 10-K.

[Genentech_2002_10-K-33] , Genentech 2002 10-K.

[Pfizer_2002_10-K-34] , Pfizer 2002 10-K.

[Eli_Lilly_&_Co._2002_10-K-35] , Eli Lilly & Co. 2002 10-K.

[Allergan_2002_10-K-36] , Allergan 2002 10-K.

[Pfizer_2001_10-K-37] , Pfizer 2001 10-K.

[Genentech_2000_10-K-38] , Genentech 2000 10-K.

[Eli_Lilly_&_Co._2000_10-K-39] , Eli Lilly & Co. 2000 10-K.

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Annual pharmaceutical drug sales

Contents

Annual Sales (2020-present)

Annual Sales (2010-2020)

Annual Sales (2000-2010)

Notes