Life extension is the concept of extending the human lifespan,either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled limit of 125 years.
Oklahoma State University–Stillwater is a public land-grant research university in Stillwater,Oklahoma. OSU was founded in 1890 under the Morrill Act. Originally known as Oklahoma Agricultural and Mechanical College,it is the flagship institution of the Oklahoma State University System that holds more than 35,000 students across its five campuses with an annual budget of $1.5 billion. The main campus enrollment for the fall 2019 semester was 24,071,with 20,024 undergraduates and 4,017 graduate students. OSU is classified among "R1:Doctoral Universities –Very high research activity". According to the National Science Foundation,OSU spent $198.8 million on research and development in 2021.
The University of Texas Southwestern Medical Center is a public academic health science center in Dallas,Texas. With approximately 18,800 employees,more than 2,900 full-time faculty,and nearly 4 million outpatient visits per year,UT Southwestern is the largest medical school in the University of Texas System and state of Texas.
Calorie restriction mimetics (CRM),also known as energy restriction mimetics,are a hypothetical class of dietary supplements or drug candidates that would,in principle,mimic the substantial anti-aging effects that calorie restriction (CR) has on many laboratory animals and humans. CR is defined as a reduction in calorie intake of 20% to 50% without incurring malnutrition or a reduction in essential nutrients. An effective CRM would alter the key metabolic pathways involved in the effects of CR itself,leading to preserved youthful health and longer lifespan without the need to reduce food intake. The term was coined by Lane,Ingram,Roth of the National Institute on Aging in a seminal 1998 paper in the Journal of Anti-Aging Medicine,the forerunner of Rejuvenation Research. A number of genes and pathways have been shown to be involved the actions of CR in model organisms and these represent attractive targets for drug discovery and for developing CRM. However,no effective CRM have been identified to date.
Oklahoma State University Center for Health Sciences (OSU-CHS) is a public medical school in Tulsa,Oklahoma. It also has a branch campus in Tahlequah,Oklahoma. Founded in 1972,OSU-CHS is part of the Oklahoma State University System. OSU-CHS offers a Doctor of Osteopathic Medicine (D.O.) and over fifteen other different graduate degrees.
The University of Texas Health Science Center at San Antonio is a public academic health science center in San Antonio,Texas. It is part of the University of Texas System.
The USC Leonard Davis School of Gerontology is one of the seventeen academic divisions of the University of Southern California in Los Angeles,focusing in undergraduate and graduate programs in gerontology,
The mammalian target of rapamycin (mTOR),also referred to as the mechanistic target of rapamycin,and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1),is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.
A branched-chain amino acid (BCAA) is an amino acid having an aliphatic side-chain with a branch. Among the proteinogenic amino acids,there are three BCAAs:leucine,isoleucine,and valine. Non-proteinogenic BCAAs include 2-aminoisobutyric acid.
The Lord Cohen Medal is a British medical award honouring individuals who "have made a considerable contribution to ageing research,either through original discoveries or in the promotion of the subject of gerontology in its broadest aspect". It is the highest award for services to gerontology in the United Kingdom and is named after British physician Henry Cohen.
Matt Kaeberlein is an American biologist and biogerontologist best known for his research on evolutionarily conserved mechanisms of aging. He is currently a professor of pathology at the University of Washington in Seattle.
Ageing (BE) or aging (AE) is the process of becoming older. The term refers mainly to humans,many other animals,and fungi,whereas for example,bacteria,perennial plants and some simple animals are potentially biologically immortal. In a broader sense,ageing can refer to single cells within an organism which have ceased dividing,or to the population of a species.
The anti-aging movement is a social movement devoted to eliminating or reversing aging,or reducing the effects of it. A substantial portion of the attention of the movement is on the possibilities for life extension,but there is also interest in techniques such as cosmetic surgery which ameliorate the effects of aging rather than delay or defeat it.
Hara Prasad Misra is an American biochemist and Professor Emeritus of Biomedical Sciences and Pathology in the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech. Misra is currently serving as Vice President for Research &Graduate Studies at the Virginia College of Osteopathic Medicine in Blacksburg,VA. Dr. Misra is a well known teacher of undergraduate,graduate and DVM professional students for a period spanning over 30 years.
Valter D. Longo is an Italian-American biogerontologist and cell biologist known for his studies on the role of fasting and nutrient response genes on cellular protection aging and diseases and for proposing that longevity is regulated by similar genes and mechanisms in many eukaryotes. He is currently a professor at the USC Davis School of Gerontology with a joint appointment in the department of Biological Sciences as well as serving as the director of the USC Longevity Institute.
Michael Nip Hall is an American-Swiss molecular biologist and professor at the Biozentrum University of Basel,Switzerland.
Rozalyn (Roz) Anderson is a professor at the University of Wisconsin School of Medicine and Public Health. She studies aging and caloric restriction in primates.
Marie A. Bernard,M.D. is the Chief Officer for Scientific Workforce Diversity at the National Institutes of Health (NIH). Prior to this,she was the Deputy Director of the National Institute on Aging at the NIH,where she oversaw approximately $3.1 billion in research focused on aging and Alzheimer's disease. Bernard co-leads the NIH UNITE initiative,launched in 2021 to end structural racism in biomedicine. She co-chairs the Inclusion Governance Committee,which promotes inclusion in clinical research by sex/gender,race/ethnicity,and age. She also co-chairs two of the Department of Health and Human Services Healthy People 2020 objectives:1) Older Adults,and 2) Dementias,including Alzheimer's Disease. Prior to arriving at NIH in 2008,Bernard served as Donald W. Reynolds Chair in Geriatric Medicine and founding chairperson of the Donald W. Reynolds Department of Geriatric Medicine at the University of Oklahoma College of Medicine,and Associate Chief of Staff for Geriatrics and Extended Care at the Oklahoma City Veterans Affairs Medical Center.
Giulio Maria Pasinetti is the Program Director of the Center on Molecular Integrative Neuroresilience and is the Saunders Family Chair in Neurology at the Icahn School of Medicine at Mount Sinai (ISMMS) in New York City. Pasinetti is a Professor of Neurology,Psychiatry,Neuroscience,and Geriatrics and Palliative Medicine at ISMMS.
This timeline lists notable events in the history of research into senescence or biological aging. People have long been interested in making their lives longer and healthier. The most anсient Egyptian,Indian and Chinese books contain reasoning about aging. Ancient Egyptians used garlic in large quantities to extend their lifespan. Hippocrates,in his Aphorisms,and Aristotle (384 – 322 BC),in On youth and old age,expressed their opinions about reasons for old age and gave advice about lifestyle. Medieval Persian physician Ibn Sina,known in the West as Avicenna,summarized the achievements of earlier generations about this issue.
