Arthur S. Tischler

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Arthur S. Tischler (born 1946) is an American surgical pathologist and professor of pathology at Tufts University School of Medicine. [1] He is best known for his research on catecholamine-producing neuroendocrine tumors, particularly pheochromocytoma [2] and paraganglioma. [3]

Contents

Career

Tischler completed his medical training and pathology residency at Beth Israel Deaconness Medical Center and Harvard Medical School in Boston (1971–1976), serving as Chief Resident in 1976. He then worked as a pathologist at Walter Reed Army Medical Center (1976–1978), before joining Tufts Medical Center.

At Tufts, he became a senior pathologist and professor of pathology and laboratory medicine. [4]

Research

Tischler's early research helped establish that pheochromocytoma cells could undergo neuron-like differentiation in response to nerve growth factor (NGF). [5]

In 1976, he and Lloyd Greene [6] co-developed the widely used PC12 cell line. [7]

He later co-developed MPC cell lines from genetically modified mice to study neuroendocrine tumors. [8]

In 2020, he co-developed RS0, the first SDHB-mutant, SDH-deficient pheochromocytoma model. [9]

Leadership and editorial roles

Tischler served as President of the Endocrine Pathology Society (2001–2002) [10] and was Editor-in-Chief of Endocrine Pathology (2002–2008). [11] He is also a founding member of the Pheochromocytoma Research Support Organization (PRESSOR), where he co-chaired the tumor models working group.

International classification work

Tischler has contributed to the World Health Organization (WHO) classification of endocrine tumors, authoring chapters in the 2004, [12] 2017, [13] and 2024 [14] editions. He also leads the expert panel on pheochromocytomas and paragangliomas for the International Collaboration on Cancer Reporting (ICCR). [15]

Recognition

Research collaborations

Tischler contributed to the Cancer Genome Atlas (TCGA) pheochromocytoma/ paraganglioma study, [18] and is a collaborator in the Australian-Asian-American Adrenal Alliance (A5) [19] . [20]

Selected publications

References

  1. ↑ "Arthur Tischler, MD | Tufts Medicine". www.tuftsmedicine.org. Retrieved 2025-05-08.
  2. ↑ Greene, L. A.; Tischler, A. S. (July 1976). "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor". Proceedings of the National Academy of Sciences of the United States of America. 73 (7): 2424–2428. Bibcode:1976PNAS...73.2424G. doi: 10.1073/pnas.73.7.2424 . ISSN   0027-8424. PMC   430592 . PMID   1065897.
  3. ↑ "Tufts Medical Center – Lead Investigator Dr. Arthur Tischler - SDHB Coalition". sdhbcoalition.org. 2020-03-24. Retrieved 2025-05-08.
  4. ↑ "Arthur Tischler, MD | Tufts Medicine". www.tuftsmedicine.org. Retrieved 2025-05-08.
  5. ↑ Tischler, AS; Greene, LA (1975). "Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells". Nature. 258 (5533): 341–342. Bibcode:1975Natur.258..341T. doi:10.1038/258341a0. PMID   1105720.
  6. ↑ "Lloyd A. Greene, PhD". Pathology. 2017-06-21. Retrieved 2025-05-08.
  7. ↑ Greene, LA; Tischler, AS (1976). "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor". Proceedings of the National Academy of Sciences. 73 (7): 2424–2428. Bibcode:1976PNAS...73.2424G. doi: 10.1073/pnas.73.7.2424 . PMC   430592 . PMID   1065897.
  8. ↑ Powers, JF; Evinger, MJ; Tsokas, P; Bedri, S; Alroy, J; Shahsavari, M; Tischler, AS (2000). "Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice". Cell and Tissue Research. 302 (3): 309–320. doi:10.1007/s004410000289. PMID   11131180.
  9. ↑ Powers, JF; Cochran, B; Baleja, JD; Sikes, HD; Pattison, AD; Zhang, X; Lomakin, I; Shepard-Barry, A; Pacak, K; Moon, SJ; Langford, TF; Stein, KT; Tothill, RW; Ouyang, Y; Tischler, AS (2020). "A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/- rats". Endocrine-Related Cancer. 27 (1): 337–354. doi: 10.1186/s12964-020-00556-3 . PMC   7171864 . PMID   32312253.
  10. ↑ "Endocrine Pathology Society" . Retrieved 2025-05-07.
  11. ↑ "Endocrine Pathology Journal – Endocrine Pathology Society" . Retrieved 2025-05-07.
  12. ↑ DeLellis, Ronald A., ed. (2004). Pathology and genetics of tumours of endocrine organs. World Health Organization classification of tumours. Lyon: IARC Press. ISBN   978-92-832-2416-7.
  13. ↑ RV, Lloyd; RY, Osamura; G, Klöppel; J, Rosai (2017). WHO Classification of Tumours of Endocrine Organs. International Agency for Research on Cancer. ISBN   978-92-832-4493-6.
  14. ↑ WHO classification of tumours: endocrine and neuroendocrine tumours (5th ed.). Lyon: International Agency for Research on Cancer, WHO. 2025. ISBN   978-92-832-4524-7.
  15. ↑ Thompson, Lester D. R.; Gill, Anthony J.; Asa, Sylvia L.; Clifton-Bligh, Roderick J.; de Krijger, Ronald R.; Kimura, Noriko; Komminoth, Paul; Lack, Ernest E.; Lenders, Jacques W. M.; Lloyd, Ricardo V.; Papathomas, Thomas G.; Sadow, Peter M.; Tischler, Arthur S. (April 2021). "Data set for the reporting of pheochromocytoma and paraganglioma: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting". Human Pathology. 110: 83–97. doi:10.1016/j.humpath.2020.04.012. ISSN   1532-8392. PMC   7655677 . PMID   32407815.
  16. ↑ "Science Honorees". PheoPara Alliance. Retrieved 2025-04-23.
  17. ↑ "Tufts School of Medicine on X: "Congratulations to Professor Arthur S. Tischler!"". X. March 28, 2025.
  18. ↑ Fishbein, L (2017). "Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma". Cancer Cell. 31 (2): 181–193. doi:10.1016/j.ccell.2017.01.001. PMC   5643159 . PMID   28162975.
  19. ↑ https://x.com/a5_adrenal
  20. ↑ Flynn, A (2025). "Multi-regional genomics of SDHB-mutated pheochromocytoma and paraganglioma". In Press.
  21. ↑ Tischler, Arthur S.; Greene, Lloyd A. (November 1975). "Nerve growth factor-induced process formation by cultured rat pheochromocytoma cells". Nature. 258 (5533): 341–342. Bibcode:1975Natur.258..341T. doi:10.1038/258341a0. ISSN   1476-4687. PMID   1196362.
  22. ↑ Greene, L A; Tischler, A S (July 1976). "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor". Proceedings of the National Academy of Sciences. 73 (7): 2424–2428. Bibcode:1976PNAS...73.2424G. doi: 10.1073/pnas.73.7.2424 . PMC   430592 . PMID   1065897.
  23. ↑ Powers, James F.; Cochran, Brent; Baleja, James D.; Sikes, Hadley D.; Pattison, Andrew D.; Zhang, Xue; Lomakin, Inna; Shepard-Barry, Annette; Pacak, Karel; Moon, Sun Jin; Langford, Troy F.; Stein, Kassi Taylor; Tothill, Richard W.; Ouyang, Yingbin; Tischler, Arthur S. (June 2020). "A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb+/- rats". Endocrine-Related Cancer. 27 (6): 337–354. doi:10.1530/ERC-19-0474. ISSN   1479-6821. PMC   7219221 . PMID   32252027.
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