B4GALT5

B4GALT5
Identifiers
Aliases	B4GALT5 , B4Gal-T5, BETA4-GALT-IV, beta4Gal-T5, beta4GalT-V, gt-V, beta-1,4-galactosyltransferase 5
External IDs	OMIM: 604016 MGI: 1927169 HomoloGene: 3507 GeneCards: B4GALT5
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.13 Start 49,632,945 bp [1] End 49,713,878 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 H3 Start 167,140,364 bp [2] End 167,191,103 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva trachea spongy bone pericardium mucosa of urinary bladder tibialis anterior muscle secondary oocyte pancreatic ductal cell bone marrow lower lobe of lung Top expressed in yolk sac proximal tubule secondary oocyte spermatocyte blood ileum adrenal gland visual cortex medial dorsal nucleus trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity galactosyltransferase activity metal ion binding beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity N-acetyllactosamine synthase activity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity Cellular component integral component of membrane Golgi cisterna membrane Golgi membrane Golgi apparatus membrane Biological process protein glycosylation keratan sulfate biosynthetic process O-glycan processing carbohydrate metabolic process poly-N-acetyllactosamine biosynthetic process ganglioside biosynthetic process via lactosylceramide central nervous system neuron axonogenesis central nervous system myelination regulation of protein stability positive regulation of embryonic development neuron maturation lipid metabolism sphingolipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9334 56336 Ensembl ENSG00000158470 ENSMUSG00000017929 UniProt O43286 Q9JMK0 RefSeq (mRNA) NM_004776 NM_019835 RefSeq (protein) NP_004767 NP_062809 Location (UCSC) Chr 20: 49.63 – 49.71 Mb Chr 2: 167.14 – 167.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-1,4-galactosyltransferase 5 is an enzyme that in humans is encoded by the B4GALT5 gene. ^{[5] [6] [7]}

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000158470 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017929 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lo NW, Shaper JH, Pevsner J, Shaper NL (Aug 1998). "The expanding beta 4-galactosyltransferase gene family: messages from the databanks". Glycobiology. 8 (5): 517–26. doi:10.1093/glycob/8.5.517. PMID   9597550.
6. Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I (Feb 1998). "Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase". Proc Natl Acad Sci U S A. 95 (2): 472–7. Bibcode:1998PNAS...95..472S. doi: 10.1073/pnas.95.2.472 . PMC   18444 . PMID   9435216.
7. "Entrez Gene: B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5".

External links

• Human B4GALT5 genome location and B4GALT5 gene details page in the UCSC Genome Browser .

Further reading

• Amado M, Almeida R, Schwientek T, Clausen H (2000). "Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions". Biochim. Biophys. Acta. 1473 (1): 35–53. doi:10.1016/S0304-4165(99)00168-3. PMID   10580128.
• Sato T, Aoki N, Matsuda T, Furukawa K (1998). "Differential effect of alpha-lactalbumin on beta-1,4-galactosyltransferase IV activities". Biochem. Biophys. Res. Commun. 244 (3): 637–41. doi:10.1006/bbrc.1998.8327. PMID   9535717.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics. 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID   11827452.
• Xu S, Zhang S, Chen C, et al. (2003). "Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line". J. Exp. Clin. Cancer Res. 21 (3): 409–14. PMID   12385586.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Sato T, Furukawa K (2004). "Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1". J. Biol. Chem. 279 (38): 39574–83. doi: 10.1074/jbc.M405805200 . PMID   15263012.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jiang J, Chen X, Shen J, et al. (2006). "Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma". J. Biol. Chem. 281 (14): 9482–9. doi: 10.1074/jbc.M504489200 . PMID   16461357.
• Sato T, Furukawa K (2007). "Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells". J. Biol. Chem. 282 (38): 27702–12. doi: 10.1074/jbc.M611862200 . PMID   17656364.
• Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans". J. Biol. Chem. 282 (41): 30085–96. doi: 10.1074/jbc.M703695200 . PMID   17690104.