BAY 2413555

BAY 2413555

Identifiers
IUPAC name 7-[(3R,4R)-3,4-dihydroxypyrrolidin-1-yl]-6-fluoro-4-oxo-N-[(2S)-3,3,4,4,4-pentafluorobutan-2-yl]-1-(2,4,6-trifluorophenyl)-1,8-naphthyridine-3-carboxamide
CAS Number	2206665-50-9
PubChem CID	172431614
Chemical and physical data
Formula	C23H17F9N4O4
Molar mass	584.399 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@H](C(C(F)(F)F)(F)F)NC(=O)C1=CN(C2=NC(=C(C=C2C1=O)F)N3C[C@H]([C@@H](C3)O)O)C4=C(C=C(C=C4F)F)F
InChI InChI=1S/C23H17F9N4O4/c1-8(22(28,29)23(30,31)32)33-21(40)11-5-36(17-12(25)2-9(24)3-13(17)26)19-10(18(11)39)4-14(27)20(34-19)35-6-15(37)16(38)7-35/h2-5,8,15-16,37-38H,6-7H2,1H3,(H,33,40)/t8-,15+,16+/m0/s1 Key:VTFWALACVWFKNO-OCJYXSBASA-N

BAY 2413555 is an experimental drug that acts as a potent and selective positive allosteric modulator of the Muscarinic acetylcholine receptor M2. It has been investigated as an agent to stabilise heart rhythm. ^[1]

References

1. Vakalopoulos A, Basting D, Brechmann M, Teller H, Boultadakis Arapinis M, Straub A, et al. (November 2024). "Discovery of BAY 2413555, First Selective Positive Allosteric Modulator of the M2 Receptor to Restore Cardiac Autonomic Balance". Journal of Medicinal Chemistry. 67 (21): 19165–19187. doi:10.1021/acs.jmedchem.4c01590. PMID   39463278.