BCAS2

BCAS2
Identifiers
Aliases	BCAS2 , DAM1, SPF27, Snt309, breast carcinoma amplified sequence 2, pre-mRNA processing factor, BCAS2 pre-mRNA processing factor
External IDs	OMIM: 605783 MGI: 1915433 HomoloGene: 4291 GeneCards: BCAS2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.2 Start 114,567,557 bp [1] End 114,581,629 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 103,078,971 bp [2] End 103,086,482 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon palpebral conjunctiva pons endothelial cell islet of Langerhans parietal pleura hair follicle biceps brachii orbitofrontal cortex Top expressed in maxillary prominence endocardial cushion superior cervical ganglion dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus atrioventricular valve somite arcuate nucleus mammillary body lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component DNA replication factor A complex catalytic step 2 spliceosome spliceosomal complex nucleolus precatalytic spliceosome Prp19 complex nucleoplasm nucleus centrosome nuclear speck U2-type catalytic step 2 spliceosome Biological process RNA splicing, via transesterification reactions mRNA processing RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10286 68183 Ensembl ENSG00000116752 ENSMUSG00000005687 UniProt O75934 Q9D287 RefSeq (mRNA) NM_005872 NM_026602 NM_001356330 NM_001356331 RefSeq (protein) NP_005863 NP_080878 NP_001343259 NP_001343260 Location (UCSC) Chr 1: 114.57 – 114.58 Mb Chr 3: 103.08 – 103.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pre-mRNA-splicing factor SPF27 is a protein that in humans is encoded by the BCAS2 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000116752 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005687 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Oct 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat Genet. 20 (1): 46–50. doi:10.1038/1700. PMID   9731529. S2CID   585778.
6. Nagasaki K, Maass N, Manabe T, Hanzawa H, Tsukada T, Kikuchi K, Yamaguchi K (Aug 1999). "Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines". Cancer Lett. 140 (1–2): 219–26. doi:10.1016/S0304-3835(99)00091-9. PMID   10403562.
7. "Entrez Gene: BCAS2 breast carcinoma amplified sequence 2".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Qi C, Zhu YT, Chang J, et al. (2005). "Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2". Biochem. Biophys. Res. Commun. 328 (2): 393–8. doi:10.1016/j.bbrc.2004.12.187. PMID   15694360.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC   133617 . PMID   12429849.
• Lee S, Ha S, Chung M, et al. (2003). "Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells". Cancer Lett. 188 (1–2): 121–6. doi:10.1016/S0304-3835(02)00055-1. PMID   12406557.
• Maass N, Rösel F, Schem C, et al. (2002). "Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer". Cancer Lett. 185 (2): 219–23. doi:10.1016/S0304-3835(02)00286-0. PMID   12169396.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.

External links

• BCAS2 human gene location in the UCSC Genome Browser .
• BCAS2 human gene details in the UCSC Genome Browser .