BCCIP

BCCIP
Identifiers
Aliases	BCCIP , TOK-1, TOK1, BRCA2 and CDKN1A interacting protein
External IDs	OMIM: 611883; MGI: 1913415; HomoloGene: 41629; GeneCards: BCCIP; OMA:BCCIP - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	125,853,695 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	133,322,874 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; parotid gland; ; gastrocnemius muscle; ; oocyte; ; islet of Langerhans; ; rectum; ; Achilles tendon; ; body of pancreas; ; monocyte; ; body of stomach;
	Top expressed in
	otic placode; ; maxillary prominence; ; primitive streak; ; saccule; ; yolk sac; ; hair follicle; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; tibialis anterior muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; kinase regulator activity ; RNA binding ; tubulin binding ;
Cellular component	nuclear cyclin-dependent protein kinase holoenzyme complex ; nucleus ; nucleoplasm ; cytosol ; centrosome ; mitotic spindle pole ; spindle pole ; cytoplasm ; centriole ; microtubule organizing center ; cytoskeleton ;
Biological process	cell cycle ; regulation of cyclin-dependent protein serine/threonine kinase activity ; neuroendocrine cell differentiation ; DNA repair ; cellular response to DNA damage stimulus ; establishment of mitotic spindle orientation ; microtubule cytoskeleton organization ; mitotic spindle organization ; microtubule anchoring ; mitotic spindle assembly ; ribosomal large subunit export from nucleus ;
	Sources:Amigo / QuickGO
Orthologs
	56647
	66165
	ENSG00000107949
	ENSMUSG00000030983
	Q9P287
	Q9CWI3
	NM_078469 ; NM_016567 ; NM_078468
	NM_025392
	NP_057651 ; NP_510868 ; NP_510869
	NP_079668
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 03, 2024

BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.^[5]^[6]^[7]

This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.^[7]

Interactions

BCCIP has been shown to interact with BRCA2,^[5] P21,^[6] and PTPmu (PTPRM)^[8]

Related Research Articles

Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. BRCA1 is a human tumor suppressor gene and is responsible for repairing DNA.

BRCA2 and BRCA2 are human genes and their protein products, respectively. The official symbol and the official name are maintained by the HUGO Gene Nomenclature Committee. One alternative symbol, FANCD1, recognizes its association with the FANC protein complex. Orthologs, styled Brca2 and Brca2, are common in other vertebrate species. BRCA2 is a human tumor suppressor gene, found in all humans; its protein, also called by the synonym breast cancer type 2 susceptibility protein, is responsible for repairing DNA.

p21^Cip1, also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest. This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.

CHEK2 is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.

DNA repair protein XRCC3 is a protein that in humans is encoded by the XRCC3 gene.

Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.

RAD52 homolog , also known as RAD52, is a protein which in humans is encoded by the RAD52 gene.

Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.

Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene.

Protein tyrosine phosphatase type IVA 2 is an enzyme that in humans is encoded by the PTP4A2 gene.

Zinc finger homeobox protein 3 is a protein that in humans is encoded by the ZFHX3 gene.

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.

Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.

E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene.

Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene.

Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene.

Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.

Transcription factor AP-2 gamma also known as AP2-gamma is a protein that in humans is encoded by the TFAP2C gene. AP2-gamma is a member of the activating protein 2 family of transcription factors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000107949 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030983 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Liu J, Yuan Y, Huan J, Shen Z (Apr 2001). "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2". Oncogene. 20 (3): 336–45. doi: 10.1038/sj.onc.1204098 . PMID 11313963.
1 2 Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H (Oct 2000). "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase". J Biol Chem. 275 (40): 31145–54. doi: 10.1074/jbc.M003031200 . PMID 10878006.
1 2 "Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein".
↑ Phillips-Mason PJ, Mourton T, Major DL, Brady-Kalnay SM (2008). "BCCIP associates with the receptor protein tyrosine phosphatase PTPmu". J Cell Biochem. 105 (4): 1059–72. doi:10.1002/jcb.21907. PMC 2758318 . PMID 18773424.

External links

Human BCCIP genome location and BCCIP gene details page in the UCSC Genome Browser .

Coleman RA, Rao P, Fogelsong RJ, Bardes ES (1992). "2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes". Biochim. Biophys. Acta. 1125 (2): 203–9. doi:10.1016/0005-2760(92)90046-X. PMID 1571364.
Machackova E, Damborsky J, Valik D, Foretova L (2002). "Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic". Hum. Mutat. 18 (6): 545. doi: 10.1002/humu.1232 . PMID 11748848. S2CID 8549550.
Armakolas A, Ladopoulou A, Konstantopoulou I, et al. (2002). "BRCA2 gene mutations in Greek patients with familial breast cancer". Hum. Mutat. 19 (1): 81–2. doi: 10.1002/humu.9003 . PMID 11754111. S2CID 25598124.
Robson M, Scheuer L, Nafa K, et al. (2002). "Unique de novo mutation of BRCA2 in a woman with early onset breast cancer". J. Med. Genet. 39 (2): 126–8. doi:10.1136/jmg.39.2.126. PMC 1735025 . PMID 11836363.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Meng X, Liu J, Shen Z (2003). "Genomic structure of the human BCCIP gene and its expression in cancer". Gene. 302 (1–2): 139–46. doi:10.1016/S0378-1119(02)01098-3. PMID 12527204.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Meng X, Liu J, Shen Z (2004). "Inhibition of G1 to S cell cycle progression by BCCIP beta". Cell Cycle. 3 (3): 343–8. doi: 10.4161/cc.3.3.672 . PMID 14726710.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Meng X, Lu H, Shen Z (2007). "BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1". Cell Cycle. 3 (11): 1457–62. doi: 10.4161/cc.3.11.1213 . PMID 15539944.
Lu H, Guo X, Meng X, et al. (2005). "The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair". Mol. Cell. Biol. 25 (5): 1949–57. doi:10.1128/MCB.25.5.1949-1957.2005. PMC 549367 . PMID 15713648.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Meng X, Yue J, Liu Z, Shen Z (2007). "Abrogation of the transactivation activity of p53 by BCCIP down-regulation". J. Biol. Chem. 282 (3): 1570–6. doi: 10.1074/jbc.M607520200 . PMC 2679999 . PMID 17135243.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000107949 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030983 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11313963-5] 1 2 Liu J, Yuan Y, Huan J, Shen Z (Apr 2001). "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2". Oncogene. 20 (3): 336–45. doi: 10.1038/sj.onc.1204098 . PMID 11313963.

[pmid10878006-6] 1 2 Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H (Oct 2000). "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase". J Biol Chem. 275 (40): 31145–54. doi: 10.1074/jbc.M003031200 . PMID 10878006.

[entrez-7] 1 2 "Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein".

[pmid18773424-8] Phillips-Mason PJ, Mourton T, Major DL, Brady-Kalnay SM (2008). "BCCIP associates with the receptor protein tyrosine phosphatase PTPmu". J Cell Biochem. 105 (4): 1059–72. doi:10.1002/jcb.21907. PMC 2758318 . PMID 18773424.

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BCCIP

Contents

Interactions

Related Research Articles

References

External links

Further reading