BEGAIN

BEGAIN
Identifiers
Aliases	BEGAIN , brain enriched guanylate kinase associated
External IDs	MGI: 3044626 HomoloGene: 10829 GeneCards: BEGAIN
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.2 Start 100,537,147 bp [1] End 100,587,413 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 F1 Start 108,998,113 bp [2] End 109,034,143 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas Brodmann area 9 amygdala anterior pituitary hippocampus proper nucleus accumbens orbitofrontal cortex superior frontal gyrus prefrontal cortex entorhinal cortex Top expressed in hypothalamus superior frontal gyrus hippocampus proper olfactory bulb cerebellar cortex neural tube anterior horn of spinal cord mesencephalon pons ganglionic eminence More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 57596 380785 Ensembl ENSG00000183092 ENSMUSG00000040867 UniProt Q9BUH8 Q68EF6 RefSeq (mRNA) NM_001159531 NM_020836 NM_001163175 NM_001374200 NM_001374201 NM_001374202 NM_001374203 RefSeq (protein) NP_001153003 NP_065887 NP_001156647 Location (UCSC) Chr 14: 100.54 – 100.59 Mb Chr 12: 109 – 109.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Brain-enriched guanylate kinase-associated protein is an enzyme that in humans is encoded by the BEGAIN gene. ^{[5] [6]}

Interactions

BEGAIN has been shown to interact with Retinoblastoma-like protein 1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000183092 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040867 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (September 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331.
6. "Entrez Gene: KIAA1446 likely ortholog of rat brain-enriched guanylate kinase-associated protein".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Human BEGAIN genome location and BEGAIN gene details page in the UCSC Genome Browser .

Further reading

• Deguchi M, Hata Y, Takeuchi M, Ide N, Hirao K, Yao I, Irie M, Toyoda A, Takai Y (1998). "BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein". J. Biol. Chem. 273 (41): 26269–72. doi: 10.1074/jbc.273.41.26269 . PMID   9756850.
• Yao I, Iida J, Nishimura W, Hata Y (2002). "Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein". J. Neurosci. 22 (13): 5354–64. doi: 10.1523/JNEUROSCI.22-13-05354.2002 . PMC   6758191 . PMID   12097487.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983.