![]() | This article may be too technical for most readers to understand.(March 2022) |
BEX4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | BEX4 , BEXL1, brain expressed X-linked 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 300692 MGI: 3606746 HomoloGene: 18948 GeneCards: BEX4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Brain expressed, X-linked 4 is a protein that in humans is encoded by the BEX4 gene. [5]
This gene is a member of the brain expressed X-linked gene family. Proteins encoded by other members of this family act as transcription elongation factors that allow RNA polymerase II to escape pausing during elongation. Multiple alternatively spliced variants encoding the same protein have been identified. [5]
DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.
Elongation factor 1-alpha 1 (eEF1a1) is a translation elongation protein, expressed across eukaryotes. In humans, it is encoded by the EEF1A1 gene.
Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene.
Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.
YAP1, also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis. YAP1 was first identified by virtue of its ability to associate with the SH3 domain of Yes and Src protein tyrosine kinases. YAP1 is a potent oncogene, which is amplified in various human cancers.
MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.
Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene.
Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene.
Dachshund homolog 1, also known as DACH1, is a protein which in humans is encoded by the DACH1 gene. DACH1 has been shown to interact with Ubc9, Smad4, and NCoR.
ID4 is a protein coding gene. In humans, it encodes for the protein known as DNA-binding protein inhibitor ID-4. This protein is known to be involved in the regulation of many cellular processes during both prenatal development and tumorigenesis. This is inclusive of embryonic cellular growth, senescence, cellular differentiation, apoptosis, and as an oncogene in angiogenesis.
Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene.
Aurora kinase C, also Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene.
Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.
Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.
Centromere protein I is a protein that in humans is encoded by the CENPI gene.
Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.
Protein Wnt-16 is a protein that in humans is encoded by the WNT16 gene. It has been proposed that stimulation of WNT16 expression in nearby normal cells is responsible for the development of chemotherapy-resistance in cancer cells.
Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.
U2AF homology motif (UHM) kinase 1, also known as UHMK1, is a protein which in humans is encoded by the UHMK1 gene.
Capicua transcriptional repressor is a protein that in humans is encoded by the CIC gene. Capicua functions as a transcriptional repressor in a way that ensures its impact on the progression of cancer, and plays a significant role in the operation of the central nervous system through its interaction with ataxin 1. The name of the protein derives from the Catalan expression cap-i-cua which literally translates to "head-and-tail".