BNC1

BNC1
Identifiers
Aliases	BNC1 , BNC, BSN1, HsT19447, basonuclin 1, POF16
External IDs	OMIM: 601930 MGI: 1097164 HomoloGene: 31048 GeneCards: BNC1
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q25.2 Start 83,255,884 bp [1] End 83,284,664 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 D3 Start 81,616,401 bp [2] End 81,642,055 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura hair follicle secondary oocyte skin of abdomen sperm pericardium stromal cell of endometrium human penis vagina Top expressed in molar secondary oocyte corneal stroma hair follicle endocardial cushion abdominal wall atrioventricular valve trigeminal ganglion skin of back iris More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity metal ion binding DNA binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus nucleoplasm intracellular membrane-bounded organelle Biological process regulation of transcription, DNA-templated positive regulation of cell population proliferation transcription, DNA-templated epidermis development spermatogenesis cell differentiation regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 646 12173 Ensembl ENSG00000169594 ENSMUSG00000025105 UniProt Q01954 O35914 RefSeq (mRNA) NM_001301206 NM_001717 NM_007562 RefSeq (protein) NP_001288135 NP_001708 NP_031588 Location (UCSC) Chr 15: 83.26 – 83.28 Mb Chr 7: 81.62 – 81.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein basonuclin-1 is a protein that in humans is encoded by the BNC1 gene. ^{[5] [6]}

The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene. ^[6]

BNC1 or Basonuclin 1 does not interact with PICK1. The suggestion that it does is based on the article that proved that PICK1 interacts with the non-voltage gated sodium channels BNC1 (brain Na⁺ channel 1). Both Basonuclin 1 and brain Na⁺ channel 1 have the same abbreviation BNC1, but they are not similar proteins and PICK1 interacts with the second protein, not the first one.

References

1. GRCh38: Ensembl release 89: ENSG00000169594 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025105 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tseng H, Green H (Dec 1992). "Basonuclin: a keratinocyte protein with multiple paired zinc fingers". Proc Natl Acad Sci U S A. 89 (21): 10311–5. Bibcode:1992PNAS...8910311T. doi: 10.1073/pnas.89.21.10311 . PMC   50328 . PMID   1332044.
6. "Entrez Gene: BNC1 basonuclin 1".

Further reading

• Tseng H (1998). "Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation". Front. Biosci. 3 (4): D985–8. doi:10.2741/A338. PMID   9727087.
• Tseng H, Green H (1994). "Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation". J. Cell Biol. 126 (2): 495–506. doi:10.1083/jcb.126.2.495. PMC   2200026 . PMID   8034748.
• Teumer J, Tseng H, Green H (1997). "The human basonuclin gene". Gene. 188 (1): 1–7. doi:10.1016/S0378-1119(96)00659-2. PMID   9099851.
• Yang Z, Gallicano GI, Yu QC, Fuchs E (1997). "An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids". J. Cell Biol. 137 (3): 657–69. doi:10.1083/jcb.137.3.657. PMC   2139879 . PMID   9151672.
• Iuchi S, Green H (1997). "Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation". Proc. Natl. Acad. Sci. U.S.A. 94 (15): 7948–53. Bibcode:1997PNAS...94.7948I. doi: 10.1073/pnas.94.15.7948 . PMC   21535 . PMID   9223293.
• Mahoney MG, Tang W, Xiang MM, et al. (1998). "Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis". Biol. Reprod. 59 (2): 388–94. doi: 10.1095/biolreprod59.2.388 . PMID   9687312.
• Iuchi S, Green H (1999). "Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9628–32. Bibcode:1999PNAS...96.9628I. doi: 10.1073/pnas.96.17.9628 . PMC   22260 . PMID   10449744.
• Tseng H, Biegel JA, Brown RS (2000). "Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes". J. Cell Sci. 112 Pt 18 (18): 3039–47. doi:10.1242/jcs.112.18.3039. PMID   10462520.
• Tang W, Tseng H (1999). "A GC-rich sequence within the 5' untranslated region of human basonuclin mRNA inhibits its translation". Gene. 237 (1): 35–44. doi:10.1016/S0378-1119(99)00299-1. PMID   10524234.
• Iuchi S, Easley K, Matsuzaki K, et al. (2000). "Alternative subcellular locations of keratinocyte basonuclin". Exp. Dermatol. 9 (3): 178–84. doi:10.1034/j.1600-0625.2000.009003178.x. PMID   10839715. S2CID   5714065.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Chen L, Willis SN, Wei A, et al. (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell. 17 (3): 393–403. doi: 10.1016/j.molcel.2004.12.030 . PMID   15694340.
• Vanhoutteghem A, Djian P (2006). "Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12423–8. Bibcode:2006PNAS..10312423V. doi: 10.1073/pnas.0605086103 . PMC   1567895 . PMID   16891417.

External links

• Human BNC1 genome location and BNC1 gene details page in the UCSC Genome Browser .