BTG4

BTG4
Identifiers
Aliases	BTG4 , PC3B, BTG family member 4, BTG anti-proliferation factor 4, APRO3, OOMD8
External IDs	OMIM: 605673 MGI: 1860140 HomoloGene: 9734 GeneCards: BTG4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	111,514,367 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	51,031,175 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; sperm; ; bronchial epithelial cell; ; right uterine tube; ; right lung; ; endometrium; ; mesencephalon; ; substantia nigra; ; cervix;
	Top expressed in
	secondary oocyte; ; spermatid; ; spermatocyte; ; seminiferous tubule; ; morula; ; ovary; ; cumulus cell; ; olfactory epithelium; ; meninges; ; blastocyst;
	More reference expression data
	n/a
Orthologs
	54766
	56057
	ENSG00000137707
	ENSMUSG00000032056
	Q9NY30
	O70552
	NM_017589 ; NM_001367974 ; NM_001367975 ; NM_001367976
	NM_019493 ; NM_001401092
	NP_060059 ; NP_001354903 ; NP_001354904 ; NP_001354905
	NP_062366 ; NP_001388021
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Protein BTG4 also known as BTG family member 4 is a protein that in humans is encoded by the BTG4 gene (B-cell translocation gene 4).^[5]^[6] BTG4 has anti-proliferative properties and can induce G₁ cell cycle arrest.^[6]

Related Research Articles

Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene and in other mammals by the homologous Btg2 gene. This protein controls cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors.

Protein Tob1 is a protein that in humans is encoded by the TOB1 gene.

Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.

CCR4-NOT transcription complex subunit 7 is a protein that in humans is encoded by the CNOT7 gene. It is a subunit of the CCR4-Not deadenylase complex.

Zinc finger homeobox protein 3 is a protein that in humans is encoded by the ZFHX3 gene.

Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene.

MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.

Protein BTG1 is a protein that in humans is encoded by the BTG1 gene.

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.

Protein SSX4 is a protein that in humans is encoded by the SSX4 gene.

Proline-rich protein PRCC is a protein that, in humans, is encoded by the PRCC gene.

Fc receptor-like protein 5 is a protein that in humans is encoded by the FCRL5 gene. FCRL5 has also been designated as CD307.

Protein BTG3 is a protein that in humans is encoded by the BTG3 gene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein that in humans is encoded by the SMARCD2 gene.

Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

Protein Tob2 is a protein that in humans is encoded by the TOB2 gene.

Translocation protein SEC62 is a protein that in humans is encoded by the SEC62 gene.

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.

Short-stature homeobox 2, also known as homeobox protein Og12X or paired-related homeobox protein SHOT, is a protein that in humans is encoded by the SHOX2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137707 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032056 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: B-cell translocation gene 4".
1 2 Buanne P, Corrente G, Micheli L, Palena A, Lavia P, Spadafora C, Lakshmana MK, Rinaldi A, Banfi S, Quarto M, Bulfone A, Tirone F (September 2000). "Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium". Genomics. 68 (3): 253–63. doi:10.1006/geno.2000.6288. PMID 10995567.

External links

Human BTG4 genome location and BTG4 gene details page in the UCSC Genome Browser .

Auer RL, Starczynski J, McElwaine S, et al. (2005). "Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia". Genes Chromosomes Cancer. 43 (1): 1–10. doi:10.1002/gcc.20159. PMID 15672409. S2CID 34431756.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Dong W, Tu S, Xie J, et al. (2009). "Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer". Biochem. Biophys. Res. Commun. 387 (1): 132–8. doi:10.1016/j.bbrc.2009.06.140. PMID 19576178. S2CID 5602860.
Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMC 5926753 . PMID 11429045.
Toyota M, Suzuki H, Sasaki Y, et al. (2008). "Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer". Cancer Res. 68 (11): 4123–32. doi: 10.1158/0008-5472.CAN-08-0325 . PMID 18519671.
Tirone F (2001). "The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?". J. Cell. Physiol. 187 (2): 155–65. doi: 10.1002/jcp.1062 . PMID 11267995. S2CID 83558340.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137707 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032056 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: B-cell translocation gene 4".

[pmid10995567-6] 1 2 Buanne P, Corrente G, Micheli L, Palena A, Lavia P, Spadafora C, Lakshmana MK, Rinaldi A, Banfi S, Quarto M, Bulfone A, Tirone F (September 2000). "Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium". Genomics. 68 (3): 253–63. doi:10.1006/geno.2000.6288. PMID 10995567.

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BTG4

Contents

Related Research Articles

References

External links

Further reading