Betty Diamond

Last updated

Betty Diamond
Born11 May 1948
Hartford, CT
Nationality American
Education Radcliffe College, Harvard Medical School
Occupation(s) Physician, Scientist
Employer The Feinstein Institute for Medical Research
Known forMedical Research

Betty Diamond (born 11 May 1948, in Hartford, Connecticut) is an American physician and researcher. She is director of the Institute of Molecular Medicine at Northwell Health's Feinstein Institute for Medical Research in Manhasset, NY. [1] She was elected a member of the National Academy of Sciences in 2022. [2] [3]

Contents

Education

Betty Diamond received her B.A. in Art History (Magna Cum) from Radcliffe College in 1969 and her M.D. from Harvard Medical School in 1973. In 1976 she began her residency at Columbia Presbyterian Medical Center, New York, NY and in 1979 embarked on post-doctoral fellowship in Immunology with Dr. Matthew Scharff at the Albert Einstein College of Medicine, Bronx, NY. [4] [1]

Academic career

Diamond has been on the faculty and chief of rheumatology at both Einstein and Columbia. She is currently head of the Center for Autoimmune and Musculoskeletal Disease at The Feinstein Institute for Medical Research and Professor of Molecular Medicine at Hofstra Northwell School of Medicine. [4] [1] She has been on the board of the American College of Rheumatology, is past president of the American Association of Immunology, and is a member of the Institute of Medicine. [5] She is also past chair of the scientific advisory board of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and has been on their Scientific Council. [6] [7] [8]

Diamond helped to establish (and named) the Advancing Women in Science and Medicine group at the Feinstein Institutes in 2010. AWSM (pronounced “awesome”) uses philanthropic support to help advance the careers of women scientists, countering gender bias and increasing gender equity. [9] [4]

Research

Diamond's primary interests are in the mechanisms of central and peripheral tolerance of autoreactive B cells, [10] [11] and the defects in these mechanisms that are present in autoimmune disease, as well as the role of antibodies in brain disease. [12] [13] Diamond identified the first idiotype marker on anti-DNA antibodies in patients with lupus, [14] [15] and discovered that anti-DNA antibodies in patients and mice shared characteristics with antibodies to pneumococcal polysaccharide. Diamond showed that a single base change in a protective anti-pneumococcal antibody could convert it into a potentially pathogenic anti-DNA antibody. She also found that a peptide that binds to 50% of anti-DNA antibodies in lupus patients and mice represents an epitope on glutamate receptors of the brain and can destroy neurons. Antibodies against the epitope are present in the cerebrospinal fluid and in brain tissue of patients with neuropsychiatric lupus. [16] [17] Her work provides a mechanism for aspects of neuropsychiatric lupus, and more generally for acquired changes in cognition and behavior. [18] [19] [20] [21] Diamond also studies the role that hormones may play in the development of lupus. [22] [23] [4]

Selected awards and honors

Related Research Articles

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<span class="mw-page-title-main">Antinuclear antibody</span> Autoantibody that binds to contents of the cell nucleus

Antinuclear antibodies are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some cases, antibodies to human antigens are produced.

Rheumatism or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. Rheumatism does not designate any specific disorder, but covers at least 200 different conditions, including arthritis and "non-articular rheumatism", also known as "regional pain syndrome" or "soft tissue rheumatism". There is a close overlap between the term soft tissue disorder and rheumatism. Sometimes the term "soft tissue rheumatic disorders" is used to describe these conditions.

Rheumatoid factor (RF) is the autoantibody that was first found in rheumatoid arthritis. It is defined as an antibody against the Fc portion of IgG and different RFs can recognize different parts of the IgG-Fc. RF and IgG join to form immune complexes that contribute to the disease process such as chronic inflammation and joint destruction at the synovium and cartilage.

<span class="mw-page-title-main">Belimumab</span> Pharmaceutical drug

Belimumab, sold under the brand name Benlysta, is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS). It is approved in the United States and Canada, and the European Union to treat systemic lupus erythematosus and lupus nephritis.

<span class="mw-page-title-main">Peter K. Gregersen</span> American geneticist

Peter K. Gregersen is a geneticist who heads the Robert S. Boas Center for Genomics and Human Genetics at Northwell's Feinstein Institute for Medical Research in Manhasset, New York, and is a professor of molecular medicine at Hofstra Northwell School of Medicine. He received his MD from Columbia University in 1976.

<span class="mw-page-title-main">Complement 2 deficiency</span> Medical condition

Complement 2 deficiency is a type of complement deficiency caused by any one of several different alterations in the structure of complement component 2.

Michael D. Lockshin is an American professor and medical researcher. He is known for his work as a researcher of autoimmune diseases, with focus on antiphospholipid syndrome and lupus. He is Professor Emeritus of Medicine and the Director Emeritus of the Barbara Volcker Center for Women and Rheumatic Disease at Hospital for Special Surgery. He retired from HSS on January 31st, 2023.

<span class="mw-page-title-main">Lupus</span> Human autoimmune disease

Lupus, technically known as systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is most commonly on the face. Often there are periods of illness, called flares, and periods of remission during which there are few symptoms.

Nicholas Chiorazzi is a physician and researcher from the United States. He is the head of the Karches Center for Chronic Lymphocytic Leukemia Research at the Feinstein Institute for Medical Research in Manhasset, New York.

<span class="mw-page-title-main">Max Dale Cooper</span> American immunologist

Max Dale Cooper, is an American immunologist and a professor at the Department of Pathology and Laboratory Medicine and the Emory Vaccine Center of Emory University School of Medicine. He is known for characterizing T cells and B cells.

Jeffrey Victor Ravetch is a professor and head of the Laboratory of Molecular Genetics and Immunology at The Rockefeller University.

Neuropsychiatric systemic lupus erythematosus or NPSLE refers to the neurological and psychiatric manifestations of systemic lupus erythematosus. SLE is a disease in which the immune system attacks the body's own cells and tissues. It can affect various organs or systems of the body. It is estimated that over half of people with SLE have neuropsychiatric involvement.

Amita Aggarwal is an Indian clinical immunologist, rheumatologist and a Professor and Head at the Department of Clinical Immunology and Rheumatology of the Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. Known for her studies in autoimmune rheumatic diseases, Aggarwal is a recipient of the Shakuntala Amir Chand Award of the Indian Council of Medical Research and an elected fellow of the National Academy of Sciences, India, National Academy of Medical Sciences and the National Academy of Medical Sciences. The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards, for her contributions to biosciences in 2004.

Daniel Jeffrey Wallace is an American rheumatologist, clinical professor, author, and fellow. Wallace has published 500 peer reviewed publications, 9 textbooks, and 28 book chapters on topics such as lupus, Sjögren syndrome, osteoarthritis, and fibromyalgia. He has the largest cohort of lupus patients in the United States (2000). A full professor of medicine, he is associate director of the Rheumatology Fellowship Program at Cedars-Sinai. His seminal contributions to research include being an author of the first paper to demonstrate vitamin D dysfunction and the importance of interleukin 6 in lupus, conducting the first large studies of apheresis in rheumatoid arthritis and lupus, and insights into the mechanisms of action of antimalarials. Wallace's research accomplishments also include conducting many clinical rheumatic disease trials, examining the role of microvascular angina and accelerated atherogenesis in lupus, and work on anti-telomere antibodies which have garnered him 6 papers in The New England Journal of Medicine. Wallace's monograph, The Lupus Book, has sold over 100,000 copies since 1995.

<span class="mw-page-title-main">Gary Firestein</span> American rheumatologist

Gary S. Firestein is an American rheumatologist, professor, and founding director of the Altman Clinical and Translational Research Institute (ACTRI) at the University of California San Diego and Senior Associate Vice Chancellor for Health Sciences at University of California, San Diego.

<span class="mw-page-title-main">Robert G. Lahita</span> American physician

Robert George Lahita is an American physician, internist and rheumatologist, best known for his research into systemic lupus erythematosus. and other autoimmune diseases. He is the author of more than 16 books and 150 scientific publications in the field of autoimmunity and immuno-endocrinology and a media consultant on health-related issues. He currently serves as Director of the Institute of Autoimmune and Rheumatic Diseases at St. Joseph's Healthcare System, specializing in autoimmunity, rheumatology, and treatment of diseases of joints, muscle, bones and tendons including arthritis, back pain, muscle strains, common athletic injuries and collagen diseases.

<span class="mw-page-title-main">Lars Klareskog</span> Biologist

Lars Klareskog is a Swedish physician, immunologist, and rheumatologist, known for research into the genetics of autoimmune diseases such as rheumatoid arthritis (RA).

Ross E. Petty is a Canadian pediatric rheumatologist. He is a professor emeritus in the Department of Pediatrics at the University of British Columbia and a pediatric rheumatologist at BC Children’s Hospital in Vancouver, Canada. He established Canada’s first formal pediatric rheumatology program at the University of Manitoba in 1976, and three years later, he founded a similar program at the University of British Columbia.

George C. Tsokos is an American immunologist who is a professor of medicine at Harvard Medical School and is the chief at Division of Rheumatology and Clinical Immunology at Beth Israel Deaconess Medical Center; Boston, MA

References

  1. 1 2 3 4 5 "Betty Diamond, MD". Feinstein Institutes for Medical Research. Retrieved 28 April 2023.
  2. 1 2 "National Academy of Sciences Elects Members and International Members". NAS Online. National Academy of Sciences. 3 May 2022. Retrieved 14 July 2022.
  3. 1 2 Zeller, Gregory (10 May 2022). "Feinstein's Diamond, SBU math whiz earn NAS nods - Innovate Long Island". Innovateli. Retrieved 28 April 2023.
  4. 1 2 3 4 Diamond, Betty (26 April 2023). "Not Dead Yet". Annual Review of Immunology. 41 (1): 1–15. doi: 10.1146/annurev-immunol-101721-065214 . ISSN   0732-0582. PMID   37126416. S2CID   258368440.
  5. 1 2 "Betty A. Diamond, M.D." The American Association of Immunologists. Retrieved 28 April 2023.
  6. ↑ "Our Team". Autoimmune Association. Retrieved 28 April 2023.
  7. ↑ "Betty Diamond, MD | Scientific Advisory Board". Arthritis National Research Foundation | Funding Research To Cure Arthritis. Retrieved 28 April 2023.
  8. ↑ "Molecular Medicine An Interview with Betty Diamond". Leaders Online. 2020. Retrieved 28 April 2023.
  9. ↑ Allen, Julianne Mosher (3 October 2022). "Betty Diamond receives Women in Medicine and Science Leadership Award | Northwell Health". Northwell Health News. Retrieved 1 May 2023.
  10. ↑ Venkatesh, Jeganathan; Peeva, Elena; Xu, Xiaonan; Diamond, Betty (15 March 2006). "Cutting Edge: Hormonal Milieu, Not Antigenic Specificity, Determines the Mature Phenotype of Autoreactive B Cells". The Journal of Immunology. 176 (6): 3311–3314. doi: 10.4049/jimmunol.176.6.3311 . PMID   16517697. S2CID   1255454.
  11. ↑ Coico, Richard; Sunshine, Geoffrey (14 January 2009). Immunology: A Short Course. John Wiley & Sons. ISBN   978-0-470-08158-7.
  12. ↑ Meislin, Margy (11 May 2022). "LRA and LT Congratulate Betty Diamond, MD on Election to the National Academy of Sciences". Lupus Research. Retrieved 28 April 2023.
  13. ↑ Kowal, Czeslawa; DeGiorgio, Lorraine A.; Lee, Ji Y.; Edgar, Mark A.; Huerta, Patricio T.; Volpe, Bruce T.; Diamond, Betty (26 December 2006). "Human lupus autoantibodies against NMDA receptors mediate cognitive impairment". Proceedings of the National Academy of Sciences. 103 (52): 19854–19859. doi: 10.1073/pnas.0608397104 . ISSN   0027-8424. PMC   1702320 . PMID   17170137.
  14. ↑ Halpern, R; Schiffenbauer, J; Solomon, G; Diamond, B (1 October 1984). "Detection of masked anti-DNA antibodies in lupus sera by a monoclonal anti-idiotype". The Journal of Immunology. 133 (4): 1852–1856. doi: 10.4049/jimmunol.133.4.1852 . ISSN   0022-1767. PMID   6332136. S2CID   25611127.
  15. ↑ Kohler, Heinz (2000). "Superantibodies" (PDF). Applied Biochemistry and Biotechnology. 83 (1–3): 1–12. doi:10.1385/ABAB:83:1-3:1. PMID   10826945.
  16. ↑ Kivity, Shaye; Katzav, Aviva; Arango, Maria Teresa; Landau-Rabi, Moran; Zafrir, Yaron; Agmon-Levin, Nancy; Blank, Miri; Anaya, Juan-Manuel; Mozes, Edna; Chapman, Joab; Shoenfeld, Yehuda (4 April 2013). "16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus". BMC Medicine. 11 (1): 90. doi: 10.1186/1741-7015-11-90 . ISSN   1741-7015. PMC   3616817 . PMID   23556432.
  17. ↑ Bosch, Xavier; Ramos-Casals, Manuel; Khamashta, Munther A. (April 2012). "The DWEYS peptide in systemic lupus erythematosus". Trends in Molecular Medicine. 18 (4): 215–223. doi:10.1016/j.molmed.2012.01.008. ISSN   1471-4914. PMID   22365619.
  18. ↑ Stock, AD; Wen, J; Putterman, C (25 December 2013). "Neuropsychiatric Lupus, the Blood Brain Barrier, and the TWEAK/Fn14 Pathway". Frontiers in Immunology. 4: 484. doi: 10.3389/fimmu.2013.00484 . ISSN   1664-3224. PMC   3872310 . PMID   24400009.
  19. ↑ Jancin, Bruce (13 April 2019). "ACE inhibitors may improve neuropsychiatric lupus". MDedge Rheumatology. Retrieved 28 April 2023.
  20. ↑ Kivity, Shaye; Agmon-Levin, Nancy; Zandman-Goddard, Gisele; Chapman, Joab; Shoenfeld, Yehuda (4 March 2015). "Neuropsychiatric lupus: a mosaic of clinical presentations". BMC Medicine. 13 (1): 43. doi: 10.1186/s12916-015-0269-8 . ISSN   1741-7015. PMC   4349748 . PMID   25858312.
  21. ↑ Govoni, Marcello; Hanly, John G (5 December 2020). "The management of neuropsychiatric lupus in the 21st century: still so many unmet needs?". Rheumatology. 59 (Supplement_5): v52–v62. doi:10.1093/rheumatology/keaa404. PMC   7719041 . PMID   33280014.
  22. ↑ Diamond, Betty; Huerta, Patricio T.; Mina-Osorio, Paola; Kowal, Czeslawa; Volpe, Bruce T. (June 2009). "Losing your nerves? Maybe it's the antibodies". Nature Reviews Immunology. 9 (6): 449–456. doi:10.1038/nri2529. ISSN   1474-1741. PMC   2783680 . PMID   19424277.
  23. ↑ Petri, M (May 2008). "Sex hormones and systemic lupus erythematosus". Lupus. 17 (5): 412–415. doi:10.1177/0961203308090026. ISSN   0961-2033. PMID   18490418. S2CID   7730215.
  24. ↑ American College of Rheumatology (11 October 2022). "American College of Rheumatology announces 2022 award recipients". EurekAlert!. Retrieved 28 April 2023.
  25. ↑ "Feinstein Institutes' Betty Diamond Elected to the National Academy of Sciences". Businesswire. 4 May 2022. Retrieved 28 April 2023.
  26. ↑ Allen, Julianne Mosher (3 October 2022). "Feinstein Institutes' Betty Diamond receives Women in Medicine and Science Leadership Award". Businesswire. Retrieved 28 April 2023.
  27. ↑ Quinn, Richard (13 January 2012). "ACR Honors Contributions to Rheumatology - Page 3 of 10". The Rheumatologist. Retrieved 28 April 2023.
  28. ↑ "Evelyn V. Hess, MD, MACP, MACR Award". Lupus Foundation of America. Retrieved 28 April 2023.
  29. ↑ "AAAS Fellows" (PDF). American Association for the Advancement of Science. Retrieved 28 April 2023.
  30. ↑ "About Us: Scientific Advisors". Lupus Research Institute. Archived from the original on 27 July 2011. Retrieved 1 August 2011.
  31. ↑ "Alumni Awards". Alumni | Albert Einstein College of Medicine. Retrieved 28 April 2023.
  32. ↑ "Past Howley Prize Recipients". The Arthritis Foundation. Retrieved 28 April 2023.
  33. ↑ "ACR Past Awards of Distinction Recipients" (PDF). American College of Rheumatology. Retrieved 1 August 2011.
  34. ↑ "New Investigators Supported". S.L.E. Lupus Foundation. Archived from the original on 14 August 2011. Retrieved 1 August 2011.
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