Bone density

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A scanner used to measure bone density using dual energy X-ray absorptiometry Bone density scanner.jpg
A scanner used to measure bone density using dual energy X-ray absorptiometry

Bone density, or bone mineral density, is the amount of bone mineral in bone tissue. The concept is of mass of mineral per volume of bone (relating to density in the physics sense), although clinically it is measured by proxy according to optical density per square centimetre of bone surface upon imaging. [1] Bone density measurement is used in clinical medicine as an indirect indicator of osteoporosis and fracture risk. It is measured by a procedure called densitometry, often performed in the radiology or nuclear medicine departments of hospitals or clinics. The measurement is painless and non-invasive and involves low radiation exposure. Measurements are most commonly made over the lumbar spine and over the upper part of the hip. [2] The forearm may be scanned if the hip and lumbar spine are not accessible.

Contents

There is a statistical association between poor bone density and higher probability of fracture. Fractures of the legs and pelvis due to falls are a significant public health problem, especially in elderly women, leading to substantial medical costs, inability to live independently and even risk of death. [3] Bone density measurements are used to screen people for osteoporosis risk and to identify those who might benefit from measures to improve bone strength.

Testing

A bone density test may detect osteoporosis or osteopenia. [4] The usual response to either of these indications is consultation with a physician. [4] Bone density tests are not recommended for people without risk factors for weak bones, [5] [4] which is more likely to result in unnecessary treatment rather than discovery of a weakness. [4]

Indications for testing

The risk factors for low bone density and primary considerations for a bone density test include:

Other considerations that are related to risk of low bone density and the need for a test include smoking habits, drinking habits, the long-term use of corticosteroid drugs, and a vitamin D deficiency. [4]

Test result terms

Results of the test are reported in three forms:

Types of tests

Illustration of Bone Densitometry Scan Blausen 0095 BoneDensitometryScan.png
Illustration of Bone Densitometry Scan

While there are many types of bone mineral density tests, all are non-invasive. The tests differ according to which bones are measured to determine the test result.

These tests include:

DXA is the most commonly used testing method as of 2016. [7] The DXA test works by measuring a specific bone or bones, usually the spine, hip, and wrist. The density of these bones is then compared with an average index based on age, sex, and size. The resulting comparison is used to determine the risk for fractures and the stage of osteoporosis (if any) in an individual.

Quantitative ultrasound (QUS) has been described as a more cost-effective approach for measuring bone density, as compared to DXA. [8]

Average bone mineral density = BMC / W [g/cm2]

Interpretation

Results are generally scored by two measures, the T-score and the Z-score. Scores indicate the amount one's bone mineral density varies from the mean. Negative scores indicate lower bone density, and positive scores indicate higher.

Less than 0.5% of patients who underwent DXA-scanning were found to have a T- or Z-score of more than +4.0, often the cause of an unusually high bone mass (HBM) and associated with mild skeletal dysplasia and the inability to float in water. [9]

T-score

The T-score is the relevant measure when screening for osteoporosis. It is the bone mineral density at the site when compared to the "young normal reference mean". It is a comparison of a patient's bone mineral density to that of a healthy 30-year-old. [10] The US standard is to use data for a 30-year-old of the same sex and ethnicity, but the WHO recommends using data for a 30-year-old white female for everyone. [11] Values for 30-year-olds are used in post-menopausal women and men over age 50 because they better predict risk of future fracture. [12] The criteria of the World Health Organization are: [13]

  • Normal is a T-score of −1.0 or higher [14]
  • Osteopenia is defined as between −1.0 and −2.5
  • Osteoporosis is defined as −2.5 or lower, meaning a bone density that is two and a half standard deviations below the mean of a 30-year-old man/woman.
Hip fractures per 1000 patient-years [15]
WHO categoryAge 50–64Age > 64Overall
Normal5.39.46.6
Osteopenia 11.419.615.7
Osteoporosis 22.446.640.6

Z-score

The Z-score for bone density is the comparison to the "age-matched normal" and is usually used in cases of severe osteoporosis. This is the standard score or number of standard deviations a patient's bone mineral density differs from the average for their age, sex, and ethnicity. This value is used in premenopausal women, men under the age of 50, and in children and adolescents. [12] [16] It is most useful when the score is less than 2 standard deviations below this normal. In this setting, it is helpful to scrutinize for coexisting illnesses or treatments that may contribute to osteoporosis such as glucocorticoid therapy, hyperparathyroidism, or alcoholism.

Prevention

To prevent low bone density it is recommended to have sufficient calcium and vitamin D. [17] [18] Sufficient calcium is defined as 1,000 mg per day, increasing to 1,200 mg for women above 50 and men above 70. [18] Sufficient vitamin D is defined as 600 IUs per day for adults 19 to 70, increasing to 800 IUs per day for those over 71. [18] Exercise, especially weight-bearing and resistance exercises are most effective for building bone. Weight-bearing exercise includes walking, jogging, dancing, and hiking. Resistance exercise is often accomplished through lifting weights. [19] Other therapies, such as estrogens (e.g., estradiol, conjugated estrogens), selective estrogen receptor modulators (e.g., raloxifene, bazedoxifene), and bisphosphonates (e.g., alendronic acid, risedronic acid), can also be used to improve or maintain bone density. Tobacco use and excessive alcohol consumption have detrimental effects on bone density. [20] [18] Excessive alcohol consumption is defined as more than one standard-sized alcoholic beverage per day for women, and drinking two or more alcoholic beverages per day for men. [18]

Genetics

Bone mineral density is highly variable between individuals. While there are many environmental factors that affect bone mineral density, genetic factors play the largest role. [7] [21] Bone mineral density variation has been estimated to have 0.6–0.8 heritability factor, meaning that 60–80% of its variation is inherited from parents. [22] Because of the heritability of bone mineral density, family history of fractures is considered as a risk factor for osteoporosis. [23] Bone mineral density is polygenic and many of the genetic mechanisms remain poorly understood. [21]

Genetic diseases associated with bone mineral density

There are several rare genetic diseases that have been associated with pathologic changes in bone mineral density. The table summarizes these diseases: [24] [23]

DiseaseGene affectedInheritanceSource
Osteogenesis imperfecta COLIA1Autosomal recessive [24] [23]
Osteogenesis imperfecta COLIA2Autosomal recessive [24] [23]
Osteoporosis pseudoglioma syndrome LRP5Autosomal recessive [23]
Osteopetrosis TCIRGIAutosomal recessive [23]
Camurati-Engelmann disease TGFβ-1Autosomal recessive [23]
Van Buchem disease SOSTAutosomal recessive [23]
Severe infantile osteopetrosisCLCN7Autosomal recessive [23]

Related Research Articles

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<span class="mw-page-title-main">Dual-energy X-ray absorptiometry</span> Diagnostic test for bone mineral density testing

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Radiofrequency Echographic Multi Spectrometry (REMS) is a non-ionizing technology for osteoporosis diagnosis and for fracture risk assessment. REMS processes the raw, unfiltered ultrasound signals acquired during an echographic scan of the axial sites, femur and spine. The analysis is performed in the frequency domain. Bone mineral density (BMD) is estimated by comparing the results against reference models.

References

  1. ↑ Bone+Density at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  2. ↑ Cole RE (June 2008). "Improving clinical decisions for women at risk of osteoporosis: dual-femur bone mineral density testing". J Am Osteopath Assoc. 108 (6): 289–95. PMID   18587077.
  3. ↑ "Preventing Falls and Related Fractures". NIH Osteoporosis and Related Bone Diseases National Resource Center. National Institute for Health. Retrieved 2021-03-12.
  4. 1 2 3 4 5 6 7 8 9 10 11 Consumer Reports; American Academy of Family Physicians (May 2012), "Bone-density tests: When you need them – and when you don't" (PDF), Choosing Wisely: an initiative of the ABIM Foundation , Consumer Reports, archived from the original (PDF) on March 4, 2016, retrieved August 14, 2012
  5. ↑ American Academy of Family Physicians, "Five Things Physicians and Patients Should Question" (PDF), Choosing Wisely: an initiative of the ABIM Foundation , presented by ABIM Foundation, American Academy of Family Physicians, archived from the original (PDF) on June 24, 2012, retrieved August 14, 2012
  6. 1 2 3 4 5 "Bone Mass Measurement". NOF. Archived from the original on 2008-03-07. Retrieved 2008-03-20.
  7. 1 2 Goolsby, Marci A.; Boniquit, Nicole (2016). "Bone Health in Athletes". Sports Health. 9 (2): 108–117. doi:10.1177/1941738116677732. PMC   5349390 . PMID   27821574.
  8. ↑ "Bone densitometry" . Retrieved 2008-09-02.
  9. ↑ Gregson CL, Steel SA, O'Rourke KP, Allan K, Ayuk J, Bhalla A, Clunie G, Crabtree N, Fogelman I, Goodby A, Langman CM, Linton S, Marriott E, McCloskey E, Moss KE, Palferman T, Panthakalam S, Poole KE, Stone MD, Turton J, Wallis D, Warburton S, Wass J, Duncan EL, Brown MA, Davey-Smith G, Tobias JH (February 2012). "'Sink or swim': an evaluation of the clinical characteristics of individuals with high bone mass". Osteoporos Int. 23 (2): 643–54. doi:10.1007/s00198-011-1603-4. PMC   3261396 . PMID   21455762.
  10. ↑ "Bone Density Scan: MedlinePlus Medical Test". medlineplus.gov. Retrieved 2020-10-29.
  11. ↑ "T and Z scores". University of Washington Bone Physics. 2011-07-29. Retrieved 2013-06-22.
  12. 1 2 Richmond, Bradford (2007-11-13). "Osteoporosis and bone mineral density". American College of Radiology. Archived from the original on 2008-09-17. Retrieved 2008-05-11.
  13. ↑ WHO Scientific Group on the Prevention and Management of Osteoporosis (2003). "Prevention and management of osteoporosis : report of a WHO scientific group" (PDF). Retrieved 2007-05-31.
  14. ↑ "Bone Mass Measurement: What the Numbers Mean". NIH Osteoporosis and Related Bone Diseases National Resource Center. National Institute for Health. Retrieved 2021-03-12.
  15. ↑ Cranney A, Jamal SA, Tsang JF, Josse RG, Leslie WD (2007). "Low bone mineral density and fracture burden in postmenopausal women". Canadian Medical Association Journal. 177 (6): 575–80. doi:10.1503/cmaj.070234. PMC   1963365 . PMID   17846439.
  16. ↑ Bachrach LK (February 2005). "Assessing bone health in children: who to test and what does it mean?". Pediatr Endocrinol Rev. 2 (Suppl 3): 332–6. PMID   16456501.
  17. ↑ Lawrence, Jean. "Building Stronger Bones". WebMD. Retrieved 2020-04-20.
  18. 1 2 3 4 5 "How to keep your bones healthy". Mayo Clinic. Retrieved 2020-04-20.
  19. ↑ "Exercise for Your Bone Health". NIH Osteoporosis and Related Bone Diseases National Resource Center. National Institute for Health. Retrieved 2020-11-09.
  20. ↑ "Smoking and Bone Health". NIH Osteoporosis and Related Bone Diseases National Resource Center. National Institute for Health. Retrieved 2022-09-19.
  21. 1 2 Yang, Tie-Lin; Shen, Hui; Liu, Anqi; Dong, Shan-Shan; Zhang, Lei; Deng, Fei-Yan; Zhao, Qi; Deng, Hong-Wen (February 2020). "A road map for understanding molecular and genetic determinants of osteoporosis". Nature Reviews Endocrinology. 16 (2): 91–103. doi:10.1038/s41574-019-0282-7. PMC   6980376 . PMID   31792439.
  22. ↑ Peacock, Munro; Turner, Charles H.; Econs, Michael J.; Foroud, Tatiana (2002-06-01). "Genetics of Osteoporosis". Endocrine Reviews. 23 (3): 303–326. doi: 10.1210/edrv.23.3.0464 . PMID   12050122.
  23. 1 2 3 4 5 6 7 8 9 Huang, Qing-Yang; Kung, Annie Wai Chee (2006-08-01). "Genetics of osteoporosis". Molecular Genetics and Metabolism. 88 (4): 295–306. doi:10.1016/j.ymgme.2006.04.009. PMID   16762578.
  24. 1 2 3 Marom, Ronit; Rabenhorst, Brien M.; Morello, Roy (2020-10-01). "Management of Endocrine Disease: Osteogenesis imperfecta: an update on clinical features and therapies". European Journal of Endocrinology. 183 (4): R95–R106. doi:10.1530/EJE-20-0299. PMC   7694877 . PMID   32621590.
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