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Oxytosis/ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides,and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis. Oxytosis/ferroptosis is initiated by the failure of the glutathione-dependent antioxidant defenses,resulting in unchecked lipid peroxidation and eventual cell death. Lipophilic antioxidants and iron chelators can prevent ferroptotic cell death. Although the connection between iron and lipid peroxidation has been appreciated for years,it was not until 2012 that Brent Stockwell and Scott J. Dixon coined the term ferroptosis and described several of its key features. Pamela Maher and David Schubert discovered the process in 2001 and called it oxytosis. While they did not describe the involvement of iron at the time,oxytosis and ferroptosis are today thought to be the same cell death mechanism.
György Kéri was a Hungarian biochemist,professor and Doctor of Biological Sciences (D.Sc.). His major field of research was signal transduction therapy and he participated in the development of novel drug discovery technologies and drug candidates that entered the clinical development process.
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Tal Danino is a synthetic biologist and Associate Professor of Biomedical Engineering at Columbia University.
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References
- ↑ "Brent R. Stockwell, Ph.D." columbia.edu. Retrieved November 15, 2020.
- ↑ Quenqua, Douglas (Winter 2011). "The Long Shot". Columbia University. Retrieved February 21, 2022.
- 1 2 3 "The 2009 Early Career Scientists: R-T". Howard Hughes Medical Institute. 2009. Retrieved February 21, 2022.
- ↑ Cameron, David (September 4, 2003). "New Compound Library to Speed Drug Discovery". Whitehead Institute . Retrieved February 21, 2022.
- ↑ Root, David E.; Flaherty, Stephen P.; Kelley, Brian P.; Stockwell, Brent R. (September 2003). "Biological Mechanism Profiling Using an Annotated Compound Library". Chemistry & Biology. 10 (9): 881–892. doi: 10.1016/j.chembiol.2003.08.009 . PMID 14522058.
- ↑ Dolma, Sonam; Lessnick, Stephen L.; Hahn, William C.; Stockwell, Brent R. (March 2003). "Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells". Cancer Cell. 3 (3): 285–296. doi: 10.1016/s1535-6108(03)00050-3 . PMID 12676586.
- ↑ "Scientists Discover New Way of Selectively Killing Cancer Cells". Phys.org. March 26, 2008. Retrieved February 21, 2022.
- ↑ "Beckman Young Investigator Award". Chemical & Engineering News. August 20, 2007. Retrieved February 21, 2022.
- ↑ "Partnership For New York City And New York City Economic Development Corporation Announce Winners Of $1.5 Million BioAccelerate". Fierce Biotech. May 4, 2010. Retrieved February 21, 2022.
- ↑ Nathan, David G. (December 2011). "On Discovering Drugs". Harvard Magazine. Retrieved February 21, 2022.
- ↑ Kroll, David (March 22, 2012). "The valiant interrogator". Nature Chemistry . 4 (239): 239. Bibcode:2012NatCh...4..239K. doi: 10.1038/nchem.1316 .
- ↑ Dixon, Scott J. (May 25, 2012). "Ferroptosis: an iron-dependent form of nonapoptotic cell death". Cell . 149 (5): 1060–1072. doi:10.1016/j.cell.2012.03.042. PMC 3367386 . PMID 22632970. S2CID 206559990.
- ↑ "Brent Stockwell Receives 2014 Lenfest Distinguished Teaching Award". Columbia University. March 25, 2014. Retrieved February 21, 2022.
- ↑ "Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors". Nature Communications . 12 (2016). April 1, 2021. Retrieved February 21, 2022.
- ↑ "The Life Sciences Power 50". City & State. August 1, 2021. Retrieved February 21, 2022.
- ↑ "Cancer Center Members Named as Highly Cited Researchers". Columbia University. November 16, 2021. Retrieved February 21, 2022.
- ↑ "Instructional Innovators Brent and Melissa Stockwell Highlighted in Columbia News". Columbia University. September 1, 2015. Retrieved February 21, 2022.
