Bunamidine

Last updated
Bunamidine
Bunamidine.svg
Identifiers
  • N,N-Dibutyl-4-hexoxynaphthalene-1-carboximidamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C25H38N2O
Molar mass 382.592 g·mol−1
3D model (JSmol)
  • CCCCCCOC1=CC=C(C2=CC=CC=C21)C(=N)N(CCCC)CCCC
  • InChI=1S/C25H38N2O/c1-4-7-10-13-20-28-24-17-16-23(21-14-11-12-15-22(21)24)25(26)27(18-8-5-2)19-9-6-3/h11-12,14-17,26H,4-10,13,18-20H2,1-3H3
  • Key:FGGFIMIICGZCCJ-UHFFFAOYSA-N

Bunamidine is an anthelmintic drug used in veterinary medicine to treat infections by tapeworm parasites of the genus Taenia ; [1] thus it is classified as a taeniacide.

It is also effective against Echinococcus granulosus (dog tapeworm) [2] and Hymenolepis diminuta (rat tapeworm). [3]

Related Research Articles

<span class="mw-page-title-main">Echinococcosis</span> Parasitic disease of tapeworms of the Echinococcus type

Echinococcosis is a parasitic disease caused by tapeworms of the Echinococcus type. The two main types of the disease are cystic echinococcosis and alveolar echinococcosis. Less common forms include polycystic echinococcosis and unicystic echinococcosis.

<span class="mw-page-title-main">Praziquantel</span> Medication

Praziquantel (PZQ), sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections in mammals, birds, amphibians, reptiles, and fish. In humans specifically, it is used to treat schistosomiasis, clonorchiasis, opisthorchiasis, tapeworm infections, cysticercosis, echinococcosis, paragonimiasis, fasciolopsiasis, and fasciolosis. It should not be used for worm infections of the eye. It is taken by mouth.

Hymenolepiasis is infestation by one of two species of tapeworm: Hymenolepis nana or H. diminuta. Alternative names are dwarf tapeworm infection and rat tapeworm infection. The disease is a type of helminthiasis which is classified as a neglected tropical disease.

Hydatid may refer to:

A cysticercoid is the larval stage of certain tapeworms, similar in appearance to a cysticercus, but having the scolex filling completely the enclosing cyst. In tapeworm infections, cysticercoids can be seen in free form as well as enclosed by cysts in biological tissues such as the intestinal mucosa. Also referred to as metacestodes, they produce proteins enabling them to invade and to survive in the host.

<span class="mw-page-title-main">Cyclophyllidea</span> Order of flatworms

Tapeworms of the order Cyclophyllidea are the most important cestode parasites of humans and domesticated animals. All have multiple proglottid "segments", and all have four suckers on their scolices (heads), though some may have other structures, as well. Proglottids of this order have genital openings on one side, and a compact yolk gland or vitellarium posterior to the ovary.

<i>Echinococcus</i> Genus of worms

Echinococcus is a genus within Cestoda, a parasitic class of the platyhelminthes phylum. Human echinococcosis is an infectious disease caused by the following species: E. granulosus, E. multilocularis, E. vogeli or E. oligarthrus.

<i>Echinococcus granulosus</i> Species of flatworm

Echinococcus granulosus, also called the hydatid worm or dog tapeworm, is a cyclophyllid cestode that dwells in the small intestine of canids as an adult, but which has important intermediate hosts such as livestock and humans, where it causes cystic echinococcosis, also known as hydatid disease. The adult tapeworm ranges in length from 3 mm to 6 mm and has three proglottids ("segments") when intact—an immature proglottid, mature proglottid and a gravid proglottid. The average number of eggs per gravid proglottid is 823. Like all cyclophyllideans, E. granulosus has four suckers on its scolex ("head"), and E. granulosus also has a rostellum with hooks. Several strains of E. granulosus have been identified, and all but two are noted to be infective in humans.

<i>Echinococcus multilocularis</i> Species of flatworm

Echinococcus multilocularis, the fox tapeworm, is a small cyclophyllid tapeworm found extensively in the northern hemisphere. E. multilocularis, along with other members of the Echinococcus genus, produce diseases known as echinococcosis. Unlike E. granulosus,E. multilocularis produces many small cysts that spread throughout the internal organs of the infected animal. The resultant disease is called Alveolar echinococcosis, and is caused by ingesting the eggs of E. multilocularis.

<span class="mw-page-title-main">Hymenolepididae</span> Family of flatworms

The Hymenolepididae are family of cyclophyllid tapeworms. Their characteristic feature is the small number of testes. The unilateral genital pores and large external seminal vesicle allow for easy recognition. Most species are small, transparent, and easy to study. The family contains over 90 genera with over 900 species, having as their definitive host birds or mammals. Most reside in the intestines of their definitive hosts. The majority of species with known lifecycles have arthropods as intermediate hosts.

<i>Hymenolepis nana</i> Species of flatworm

Dwarf tapeworm is a cosmopolitan species though most common in temperate zones, and is one of the most common cestodes infecting humans, especially children.

<i>Hymenolepis diminuta</i> Species of flatworm

Hymenolepis diminuta, also known as rat tapeworm, is a species of Hymenolepis tapeworm that causes hymenolepiasis. It has slightly bigger eggs and proglottids than H. nana and infects mammals using insects as intermediate hosts. The adult structure is 20 to 60 cm long and the mature proglottid is similar to that of H. nana, except it is larger.

<span class="mw-page-title-main">Taeniidae</span> Family of flatworms

The Taeniidae are a family of tapeworms. It is the largest family representing the order Cyclophyllidea. It includes many species of medical and veterinary importance, as Taenia solium, Taenia saginata, and Echinococcus granulosus. The Taeniidae are parasites of mammals and many are infectious to humans.

<i>Hymenolepis</i> (flatworm) Genus of worms

Hymenolepis is a genus of cyclophyllid tapeworms that cause hymenolepiasis. They parasitise mammals, including humans. Some notable species are:

<span class="mw-page-title-main">Cestoda</span> Class of flatworms

Cestoda is a class of parasitic worms in the flatworm phylum (Platyhelminthes). Most of the species—and the best-known—are those in the subclass Eucestoda; they are ribbon-like worms as adults, known as tapeworms. Their bodies consist of many similar units known as proglottids—essentially packages of eggs which are regularly shed into the environment to infect other organisms. Species of the other subclass, Cestodaria, are mainly fish infecting parasites.

<i>Hymenolepis microstoma</i> Species of flatworm

Hymenolepis microstoma, also known as the rodent tapeworm, is an intestinal dwelling parasite. Adult worms live in the bile duct and small intestines of mice and rats, and larvae metamorphose in the haemocoel of beetles. It belongs to the genus Hymenolepis; tapeworms that cause hymenolepiasis. H. microstoma is prevalent in rodents worldwide, but rarely infects humans.

<span class="mw-page-title-main">Oxfendazole</span> Chemical compound

Oxfendazole is a broad spectrum benzimidazole anthelmintic. Its main use is for protecting livestock against roundworm, strongyles and pinworms. Oxfendazole is the sulfoxide metabolite of fenbendazole.

<span class="mw-page-title-main">Epsiprantel</span> Chemical compound

Epsiprantel is a veterinary drug which is used as an anthelmintic against tapeworms such as Echinococcus granulosus.

<span class="mw-page-title-main">Rostellum (helminth)</span> Feature of tapeworm anatomy

Rostellum in helminthology is a protruding part of the anterior end of tapeworms. It is a retractable, cone-like muscular structure that is located on the apical end of the scolex, and in most species is armed with hooks, the organs of attachment to the host's intestinal wall. It is a parasitic adaptation in some cestodes for firm attachment in the gastrointestinal tract and is structurally different from one species to another, thereby becoming an important diagnostic feature.

References

  1. "Bunamidine". DrugBank .
  2. Andersen FL, Loveless RM, Jensen LA (May 1975). "Efficacy of bunamidine hydrochloride against immature and mature stages of Echinococcus granulosus". American Journal of Veterinary Research. 36 (5): 673–675. PMID   1169897.
  3. Chatfield RC, Yeary RA (1979). "The effects of bunamidine HCL on Hymenolepis diminuta in vitro". Veterinary Parasitology. 5 (2–3): 177–193. doi:10.1016/0304-4017(79)90008-6.