C1D | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | C1D , LRP1, SUN-CoR, SUNCOR, hRrp47, C1D nuclear receptor corepressor | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 606997 MGI: 1927354 HomoloGene: 4619 GeneCards: C1D | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the C1D gene. [5] [6] [7] [8] [9] [10] The C1D protein is encoded by a DNA binding gene traced in the nucleus. [11] Protein C1D has a chromosomal location of 2p14. [12] C1D has a family of proteins consisting of C1D homologues which may include Sas10 domains. [13] C1D is thought to bind to RNA and DNA where it may be involved in mechanisms of DNA repair. [13] Protein C1D is ubiquitously expressed in different human tissues. [14]
Despite inducing denaturing conditions, C1D shows high-affinity binding to DNA. [13] C1D has demonstrated capability to bind to DNA in DNA repair pathways. [13]
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Protein C1D may have a protective effect against relation to the TRAX/Translin complex formation of DNA. [13] Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined. [10]
C1D has been shown to interact with TSNAX [8] and DNA-PKcs. [15] C1D has also shown to interact notably in mammalian cells and yeast. [16] Interaction in mammalian cells only occur ensuing gamma-irradiation. [16]
The protein C1D is thought to be expressed ubiquitously. [14] It may be expressed in high levels in the mammary gland, thyroid gland, salivary gland, medulla oblongata, and hippocampus. [14] It may be expressed at lower levels in the appendix, heart, lungs, skeletal muscles, and colon. [14]
Ras-related C3 botulinum toxin substrate 3 (Rac3) is a G protein that in humans is encoded by the RAC3 gene. It is an important component of intracellular signalling pathways. Rac3 is a member of the Rac subfamily of the Rho family of small G proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.
Barrier-to-autointegration factor is a protein that in humans is encoded by the BANF1 gene. It is a member of the barrier-to-autointegration factor family of proteins.
Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.
60S ribosomal protein L40 (RPL40) is a protein that in humans is encoded by the UBA52 gene.
Translin is a DNA-binding protein that in humans is encoded by the TSN gene. Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).
Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene. This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2, which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Nuclear receptor-binding protein is a protein that in humans is encoded by the NRBP1 gene.
DNA-binding protein A is a protein that in humans is encoded by the CSDA gene.
DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene.
Fas-activated serine/threonine kinase is an enzyme that in humans is encoded by the FASTK gene.
Translin-associated protein X is a protein that in humans is encoded by the TSNAX gene.
Bcl-2-associated transcription factor 1 is a Bcl-2 family protein in humans that is encoded by the BCLAF1 gene.
Dysbindin domain-containing protein 2 is a protein that in humans is encoded by the DBNDD2 gene.
Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.
Heterogeneous nuclear ribonucleoprotein D-like, also known as HNRPDL, is a protein which in humans is encoded by the HNRPDL gene.
Apoptosis-inducing factor 2 (AIFM2), also known as ferroptosis suppressor protein 1 (FSP1), apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID), is a protein that in humans is encoded by the AIFM2 gene, also known as p53-responsive gene 3 (PRG3), on chromosome 10.
Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.
Zinc finger protein 239 is a protein that in humans is encoded by the ZNF239 gene.
Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.
PBX/Knotted 1 Homeobox 2 (PKNOX2) protein belongs to the three amino acid loop extension (TALE) class of homeodomain proteins, and is encoded by PKNOX2 gene in humans. The protein regulates the transcription of other genes and affects anatomical development.