C1QTNF4 (gene)

C1QTNF4
Identifiers
Aliases	C1QTNF4 , CTRP4, ZACRP4, C1q and tumor necrosis factor related protein 4, C1q and TNF related 4
External IDs	OMIM: 614911 MGI: 1914695 HomoloGene: 12134 GeneCards: C1QTNF4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	47,594,411 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	90,720,869 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; cerebellar vermis; ; cerebellum; ; putamen; ; superior frontal gyrus; ; dorsolateral prefrontal cortex; ; nucleus accumbens; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity ; molecular function ;
Cellular component	extracellular region ; extracellular space ;
Biological process	regulation of signaling receptor activity ; positive regulation of interleukin-6 production ; positive regulation of interleukin-6-mediated signaling pathway ; positive regulation of NIK/NF-kappaB signaling ; signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	114900
	67445
	ENSG00000172247 ; ENSG00000284838
	ENSMUSG00000040794
	Q9BXJ3
	Q8R066
	NM_031909
	NM_026161
	NP_114115
	NP_080437
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2022

C1q and tumor necrosis factor related protein 4 is a protein that in humans is encoded by the C1QTNF4 gene. ^[5]

Related Research Articles

Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is encoded by the TNFSF9 gene.

Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.

Death receptor 6 (DR6), also known as tumor necrosis factor receptor superfamily member 21 (TNFRSF21), is a cell surface receptor of the tumor necrosis factor receptor superfamily which activates the JNK and NF-κB pathways. It is mostly expressed in the thymus, spleen and white blood cells. The Gene for DR6 is 78,450 bases long and is found on the 6th chromosome. This is transcribed into a 655 amino acid chain weighing 71.8 kDa. Post transcriptional modifications of this protein include glycosylation on the asparagines at the 82, 141, 252, 257, 278, and 289 amino acid locations.

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.

Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human gene.

Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is one of two membrane receptors that binds tumor necrosis factor-alpha (TNFα). Like its counterpart, tumor necrosis factor receptor 1 (TNFR1), the extracellular region of TNFR2 consists of four cysteine-rich domains which allow for binding to TNFα. TNFR1 and TNFR2 possess different functions when bound to TNFα due to differences in their intracellular structures, such as TNFR2 lacking a death domain (DD).

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.

Complement C1q tumor necrosis factor-related protein 1 is a protein that in humans is encoded by the C1QTNF1 gene.

Tumor necrosis factor, alpha-induced protein 8 is a protein that in humans is encoded by the TNFAIP8 gene. It is preferentially expressed in human immune cell types.

Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.

SH3 domain-binding glutamic acid-rich-like protein 3 is a protein that in humans is encoded by the SH3BGRL3 gene.

Complement C1q tumor necrosis factor-related protein 3 is a protein that in humans is encoded by the C1QTNF3 gene.

Family with sequence similarity 132, member A also known as adipolin is a protein that in humans is encoded by the FAM132A gene. Adipolin is an adipokine.

Eva-1 homolog A is a protein that in humans is encoded by the EVA1A gene.

CKLF like MARVEL transmembrane domain-containing 7, previously termed chemokine-like factor superfamily 7, is a protein that in humans is encoded by the CMTM7 gene. This gene, which is located in band 22 on the short arm of chromosome 3, and the protein that it encodes belong to the CKLF-like MARVEL transmembrane domain-containing family. Through the process of alternative splicing, the CMTM7 gene encodes two isoforms, CMTM7-v1 and CMTM7-v2, with CMTM7-v1 being the main form expressed and studied. CMTM7 proteins are widely expressed in normal human tissues.

Mediator complex subunit 19 (Med19) is a protein that in humans is encoded by the MED19 gene.

TNF alpha induced protein 8 like 2 (TNFAIP8L2), also known as TIPE2, is a protein that in humans is encoded by the TNFAIP8L2 gene. It is preferentially expressed in human myeloid cell types and serves as an immune checkpoint regulator of inflammation and metabolism.

SRY-box 7 is a protein that in humans is encoded by the SOX7 gene.

Immediate early response 2 is a protein that in humans is encoded by the IER2 gene.

References

1 2 3 ENSG00000284838 GRCh38: Ensembl release 89: ENSG00000172247, ENSG00000284838 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040794 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: C1q and tumor necrosis factor related protein 4" . Retrieved 2016-12-01.

C1QTNF4 (gene)

Related Research Articles

References

Further reading