C6orf62 Last updated October 31, 2025 Protein-coding gene in the species Homo sapiens
Chromosome 6 open reading frame 62 (C6orf62), also known as X-trans-activated protein 12 (XTP12), [ 5] is a gene that encodes a protein of the same name. The encoded protein is predicted to have a subcellular location within the cytosol. [ 6]
Gene and Transcript In the DNA, C6orf62 is 12,529 base pairs long and is located at 6q22.3. [ 7] It is located on chromosome 6 on position 22.3 (6q22.3). The mature mRNA sequence is 2498 base-pairs long with 5 exons and 4 intronic regions that translates a protein that is 229 amino acids long and two predicted isoforms of 160 amino acids and 200 amino acids. [ 8] [ 9]
Protein The main transcript is 229 amino acids long and is encoded from 5 exonic regions. There exists two transcript variants that are 200 amino acids and 160 amino acids long. There is a domain of unknown function (DUF4566) present in all three variants and spans positions 1–226 on the main transcript. [ 10] The molecular weight of C6orf62 is 27.1 kDa and its isoelectric point is at a pH of 9.24. [ 11] It is located subcellularly localized throughout the cytosol. [ 6]
Homology C6orf62 is highly conserved among vertebrates and has orthologs found in invertebrates.
Orthologs in Select Mammals Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity Pongo abelii Sumatran Orangutan 15.2 NP_001126883.1 232 99 99 Ictidomys tridecemlineatus Ground Squirrel 88 XP_005337081.1 231 99 98 Tupaia chinensis Treeshrew 85 XP_006162754.1 267 84 98 Rattus norvegicus Brown Rat 88 NP_001017510.1 232 99 98
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Orthologs in Select Ray-Finned Fish Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity Salmo salar Salmon 435 XP_014034327.1 233 82 93 Sinocyclocheilus rhinoceros Golden-lined Barbell 435 XP_016388718.1 230 87 94 Hippocampus comes Seahorse 435 XP_019729847.1 234 80 91
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Orthologs in Select Amphibians Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity Nanorana parkeri High Himalaya Frog 353 XP_018411819.1 232 95 97 Xenopus trpocalis African Clawed Frog 353 NP_001120278.1 232 93 98
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Orthologs in Select Reptiles Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity Chrysemys picta belli Painted Turtle 320 XP_005281462.1 233 97 98 Python vbivittatus Burmese Python 320 XP_007521998.1 233 96 99 Chelonia mydas Green Sea Turtle 320 XP_007060449.1 231 97 98 Alligator sinensis Chinese Alligator 320 XP_006034488.1 232 98 99
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Orthologs in Select Birds Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity Tauraco erythrolophus Red-crested Tauraco 320 XP_009991398.1 232 97 Taeniopygia guttata Zebra Finch 320 XP_002194166.1 232 98 Manacus vitellinus Gold Marked Manakin 320 XP_017925511.1 241 98
Orthologs in Select Invertebrates [ 15]
Genus Species Common name Date of divergence (MYA) RefSeq AA Length % Identity % Similarity Ciona intestinalis Sea Squirt 677 XP_002119736.1 233 38 62 Crassostrea gigas Pacific Oyster 758 XP_011438527.1 231 62 80 Hellobdella robusta Glossiphoniidae Leech 758 XP_009016977.1 264 35 51 Octopus bimaculoides Two-Spot Octopus 758 XP_014780369.1 197 60 79 Saccoglossus kowalevskii Acorn Worm 627 XP_002741666.1 230 66 83
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References 1 2 3 GRCh38: Ensembl release 89: ENSG00000112308 – Ensembl , May 2017 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019132 – Ensembl , May 2017 ↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ↑ Database, GeneCards Human Gene. "C6orf62 Gene - GeneCards | CF062 Protein | CF062 Antibody" . www.genecards.org . Retrieved 2017-02-21 . 1 2 "Tissue expression of C6orf62 - Summary - The Human Protein Atlas" . www.proteinatlas.org . Retrieved 2017-05-08 . ↑ Kent, WJ; Sugnet, CW; Furey, TS; Roskin, KM; Pringle, TH; Zahler, AM; Haussler, D (2002). "UCSC Genome Browser" . UCSC Genome Browser . Retrieved 2017-02-20 . ↑ "PREDICTED: uncharacterized protein C6orf62 isoform X1 [ Homo sapiens] - Protein - NCBI" . www.ncbi.nlm.nih.gov . Retrieved 2017-05-08 . ↑ "PREDICTED: uncharacterized protein C6orf62 isoform X2 [ Homo sapiens] - Protein - NCBI" . www.ncbi.nlm.nih.gov . Retrieved 2017-05-08 . ↑ "C6orf62 chromosome 6 open reading frame 62 [ Homo sapiens (human)] - Gene - NCBI" . www.ncbi.nlm.nih.gov . Retrieved 2017-05-08 . ↑ Volker, Brendel (2006). "SAPS - SDSC Bio Workbench" . SDSC Biology Workbench . Retrieved 2017-05-01 . [ permanent dead link ] 1 2 Lab, Mike Tyers. "C6orf62 (RP1-30M3.4) Result Summary | BioGRID" . thebiogrid.org . Retrieved 2017-05-08 . ↑ "1 binary interaction found for search term C6orf62" . IntAct Molecular Interaction Database . EMBL-EBI. Retrieved 2018-08-25 . ↑ "C6orf62 protein abundance in PaxDb" . pax-db.org . Retrieved 2017-05-08 . 1 2 3 4 5 6 "NCBI - Basic Local Alignment Search Tool" . NCBI . This page is based on this
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