CABLES1

CABLES1
Identifiers
Aliases	CABLES1 , CABL1, CABLES, HsT2563, IK3-1, Cdk5 and Abl enzyme substrate 1
External IDs	OMIM: 609194; MGI: 1927065; HomoloGene: 11097; GeneCards: CABLES1; OMA:CABLES1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q11.2 Start 23,134,564 bp [1] End 23,260,470 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 A1 Start 11,972,277 bp [2] End 12,078,687 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in putamen nucleus accumbens caudate nucleus internal globus pallidus external globus pallidus amygdala pars reticulata right frontal lobe entorhinal cortex cingulate gyrus Top expressed in habenula cumulus cell lumbar subsegment of spinal cord nucleus of stria terminalis lacrimal gland otic vesicle substantia nigra central gray substance of midbrain Paneth cell suprachiasmatic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm cytosol nucleus Biological process cell cycle regulation of cell cycle cell division nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91768 63955 Ensembl ENSG00000134508 ENSMUSG00000040957 UniProt Q8TDN4 Q9ESJ1 RefSeq (mRNA) NM_001100619 NM_001256438 NM_138375 NM_001146287 NM_022021 RefSeq (protein) NP_001094089 NP_001243367 NP_612384 NP_001139759 NP_071304 Location (UCSC) Chr 18: 23.13 – 23.26 Mb Chr 18: 11.97 – 12.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene. ^{[5] [6]}

CABLES1 is a cyclin-dependent kinase (CDK)-binding protein that plays a role in proliferation and/or cell differentiation. ^[7] [supplied by OMIM]. ^[6] It is a tumor suppressor gene which losing it (by mutations, knockout, knockdown or inactivation) may lead to colorectal cancer CRC. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000134508 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040957 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1".
7. Zukerberg LR, DeBernardo RL, Kirley SD, et al. (2004). "Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer". Cancer Res. 64 (1): 202–8. doi: 10.1158/0008-5472.CAN-03-2833 . PMID   14729625.
8. "Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in ApcMin mice". Cancer Biol Ther. PMID   23792637.

External links

• Human CABLES1 genome location and CABLES1 gene details page in the UCSC Genome Browser .

Further reading

• Matsuoka M, Matsuura Y, Semba K, Nishimoto I (2000). "Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo". Biochem. Biophys. Res. Commun. 273 (2): 442–7. doi:10.1006/bbrc.2000.2965. PMID   10873625.
• Zukerberg LR, Patrick GN, Nikolic M, et al. (2000). "Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth" (PDF). Neuron. 26 (3): 633–46. doi:10.1016/S0896-6273(00)81200-3. hdl: 1721.1/83489 . PMID   10896159. S2CID   15142577.
• Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. doi:10.1006/bbrc.2001.5493. PMID   11527406.
• Wu CL, Kirley SD, Xiao H, et al. (2001). "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers". Cancer Res. 61 (19): 7325–32. PMID   11585773.
• Tsuji K, Mizumoto K, Yamochi T, et al. (2002). "Differential effect of ik3-1/cables on p53- and p73-induced cell death". J. Biol. Chem. 277 (4): 2951–7. doi: 10.1074/jbc.M108535200 . PMID   11706030.
• Yamochi T, Semba K, Tsuji K, et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". Eur. J. Biochem. 268 (23): 6076–82. doi:10.1046/j.0014-2956.2001.02555.x. PMID   11733001.
• Sato H, Nishimoto I, Matsuoka M (2002). "ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl". Biochim. Biophys. Acta. 1574 (2): 157–63. doi:10.1016/S0167-4781(01)00367-0. PMID   11955625.
• Tan D, Kirley S, Li Q, et al. (2003). "Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study". Hum. Pathol. 34 (2): 143–9. doi:10.1053/hupa.2003.26. PMID   12612882.
• Dong Q, Kirley S, Rueda B, et al. (2004). "Loss of cables, a novel gene on chromosome 18q, in ovarian cancer". Mod. Pathol. 16 (9): 863–8. doi: 10.1097/01.MP.0000084434.88269.0A . PMID   13679449.
• Matsuoka M, Sudo H, Tsuji K, et al. (2004). "ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways". Biochem. Biophys. Res. Commun. 312 (2): 520–9. doi:10.1016/j.bbrc.2003.10.142. PMID   14637168.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang H, Duan HO, Kirley SD, et al. (2006). "Aberrant splicing of cables gene, a CDK regulator, in human cancers". Cancer Biol. Ther. 4 (11): 1211–5. doi:10.4161/cbt.4.11.2085. PMID   16177568. S2CID   11303727.
• Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18". Nature. 437 (7058): 551–5. Bibcode:2005Natur.437..551N. doi: 10.1038/nature03983 . PMID   16177791.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464–70. doi: 10.1016/j.febslet.2006.10.065 . PMID   17101133. S2CID   20005197.