CABYR

CABYR
Identifiers
Aliases	CABYR , CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2, calcium binding tyrosine phosphorylation regulated
External IDs	OMIM: 612135 MGI: 1918382 HomoloGene: 49299 GeneCards: CABYR
Gene location (Human)
Chr.	Chromosome 18 (human)
End	24,161,600 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	12,888,317 bp
RNA expression pattern
	Top expressed in
	sperm; ; oocyte; ; right uterine tube; ; secondary oocyte; ; anterior pituitary; ; Brodmann area 9; ; prefrontal cortex; ; canal of the cervix; ; ganglionic eminence; ; amygdala;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; ascending aorta; ; superior frontal gyrus; ; aortic valve; ; secondary oocyte; ; cerebellar cortex; ; substantia nigra; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding ; enzyme binding ; calcium ion binding ; protein binding ; protein domain specific binding ; metal ion binding ; protein heterodimerization activity ;
Cellular component	cytoplasm ; sperm principal piece ; cell projection ; motile cilium ; cilium ; sperm fibrous sheath ; cytoskeleton ; nucleus ; sperm end piece ; cytosol ; extracellular region ;
Biological process	sperm capacitation ; epithelial cilium movement involved in extracellular fluid movement ;
	Sources:Amigo / QuickGO
Orthologs
	26256
	71132
	ENSG00000154040
	ENSMUSG00000024430
	O75952
	Q9D424
NM_001308231 ; NM_012189 ; NM_138643 ; NM_138644 ; NM_153768 ;
	NM_153769 ; NM_153770
	NM_001042418 ; NM_001042419 ; NM_001042420 ; NM_027687 ; NM_181731 Contents References ; External links ; Further reading ;
NP_001295160 ; NP_036321 ; NP_619584 ; NP_619585 ; NP_722452 ;
	NP_722453 ; NP_722454 ; NP_001295160.1
	NP_001035883 ; NP_001035884 ; NP_001035885 ; NP_081963 ; NP_859420
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.^[5]^[6]^[7]^[8]

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.^[8]

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Fibrous sheath CABYR binding protein is a protein that in humans is encoded by the FSCB gene, which is found on chromosome 14. It is found in Homo sapiens, and has the following lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. The sub-cellular function of the protein is to localize to the cortex of the fibrous sheath, including the surface of the longitudinal columns and ribs of the main part of sperm flagella.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000154040 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024430 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC (Jan 2002). "CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation". Dev Biol. 242 (2): 236–54. doi: 10.1006/dbio.2001.0527 . PMID 11820818.
↑ Luo C, Xiao X, Liu D, Chen S, Li M, Xu A, Liu J, Gao S, Wu S, He D (Feb 2007). "CABYR is a novel cancer-testis antigen in lung cancer". Clin Cancer Res. 13 (4): 1288–97. doi: 10.1158/1078-0432.CCR-06-1742 . PMID 17317841.
↑ Kim YH, Jha KN, Mandal A, Vanage G, Farris E, Snow PL, Klotz K, Naaby-Hansen S, Flickinger CJ, Herr JC (Oct 2005). "Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A". Dev Biol. 286 (1): 46–56. doi: 10.1016/j.ydbio.2005.07.005 . PMID 16139264.
1 2 "Entrez Gene: CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)".

External links

Human CABYR genome location and CABYR gene details page in the UCSC Genome Browser .

Fouquet JP; Kann ML (1995). "The cytoskeleton of mammalian spermatozoa". Biol. Cell. 81 (2): 89–93. doi:10.1016/S0248-4900(94)80001-4. PMID 7849610. S2CID 39352537.
Visconti PE, Westbrook VA, Chertihin O, et al. (2002). "Novel signaling pathways involved in sperm acquisition of fertilizing capacity". J. Reprod. Immunol. 53 (1–2): 133–50. doi:10.1016/S0165-0378(01)00103-6. PMID 11730911.
Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ficarro S, Chertihin O, Westbrook VA, et al. (2003). "Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation". J. Biol. Chem. 278 (13): 11579–89. doi: 10.1074/jbc.M202325200 . PMID 12509440.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hsu HC, Lee YL, Cheng TS, et al. (2005). "Characterization of two non-testis-specific CABYR variants that bind to GSK3beta with a proline-rich extensin-like domain". Biochem. Biophys. Res. Commun. 329 (3): 1108–17. doi:10.1016/j.bbrc.2005.02.089. PMID 15752768.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000154040 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024430 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11820818-5] Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC (Jan 2002). "CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation". Dev Biol. 242 (2): 236–54. doi: 10.1006/dbio.2001.0527 . PMID 11820818.

[pmid17317841-6] Luo C, Xiao X, Liu D, Chen S, Li M, Xu A, Liu J, Gao S, Wu S, He D (Feb 2007). "CABYR is a novel cancer-testis antigen in lung cancer". Clin Cancer Res. 13 (4): 1288–97. doi: 10.1158/1078-0432.CCR-06-1742 . PMID 17317841.

[pmid16139264-7] Kim YH, Jha KN, Mandal A, Vanage G, Farris E, Snow PL, Klotz K, Naaby-Hansen S, Flickinger CJ, Herr JC (Oct 2005). "Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A". Dev Biol. 286 (1): 46–56. doi: 10.1016/j.ydbio.2005.07.005 . PMID 16139264.

[entrez-8] 1 2 "Entrez Gene: CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)".

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CABYR

Contents

Related Research Articles

References

External links

Further reading