CACUL1

CACUL1
Identifiers
Aliases	CACUL1 , C10orf46, CAC1, CDK2 associated cullin domain 1
External IDs	MGI: 1926082 HomoloGene: 17821 GeneCards: CACUL1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	118,755,249 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	60,569,463 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; pancreatic epithelial cell; ; endothelial cell; ; germinal epithelium; ; parietal pleura; ; visceral pleura; ; nipple; ; deltoid muscle; ; palpebral conjunctiva; ; vena cava;
	Top expressed in
	spermatid; ; seminiferous tubule; ; arcuate nucleus; ; median eminence; ; extensor digitorum longus muscle; ; cingulate gyrus; ; plantaris muscle; ; paraventricular nucleus of hypothalamus; ; triceps brachii muscle; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; protein kinase binding ; ubiquitin protein ligase binding ; ubiquitin protein ligase activity ;
Cellular component	cullin-RING ubiquitin ligase complex ;
Biological process	cell cycle ; ubiquitin-dependent protein catabolic process ; positive regulation of cell population proliferation ; positive regulation of protein kinase activity ; G1/S transition of mitotic cell cycle ; protein ubiquitination ;
	Sources:Amigo / QuickGO
Orthologs
	143384
	78832
	ENSG00000151893
	ENSMUSG00000033417
	Q86Y37
	Q8R0X2
	NM_153810
	NM_001172096 ; NM_001172097 ; NM_030197
	NP_722517
	NP_001165567 ; NP_001165568 ; NP_084473
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 30, 2023

CDK2 associated cullin domain 1 is a protein that in humans is encoded by the CACUL1 gene. ^[5]

Related Research Articles

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Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, also known as Cdk1 in humans. It is a catalytic subunit of the cyclin-dependent kinase complex, whose activity is restricted to the G1-S phase of the cell cycle, where cells make proteins necessary for mitosis and replicate their DNA. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin E or A. Cyclin E binds G1 phase Cdk2, which is required for the transition from G1 to S phase while binding with Cyclin A is required to progress through the S phase. Its activity is also regulated by phosphorylation. Multiple alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. The role of this protein in G1-S transition has been recently questioned as cells lacking Cdk2 are reported to have no problem during this transition.

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Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb.

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates ; phosphorylation of these proteins leads to cell cycle progression.

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M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.

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Cyclin-A2 is a protein that in humans is encoded by the CCNA2 gene. It is one of the two types of cyclin A: cyclin A1 is expressed during meiosis and embryogenesis while cyclin A2 is expressed in the mitotic division of somatic cells.

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Cyclin-dependent kinases regulatory subunit 1 is a protein that in humans is encoded by the CKS1B gene.

Cullin-4B is a protein that in humans is encoded by the CUL4B gene which is located on the X chromosome. CUL4B has high sequence similarity with CUL4A, with which it shares certain E3 ubiquitin ligase functions. CUL4B is largely expressed in the nucleus and regulates several key functions including: cell cycle progression, chromatin remodeling and neurological and placental development in mice. In humans, CUL4B has been implicated in X-linked intellectual disability and is frequently mutated in pancreatic adenocarcinomas and a small percentage of various lung cancers. Viruses such as HIV can also co-opt CUL4B-based complexes to promote viral pathogenesis. CUL4B complexes containing Cereblon are also targeted by the teratogenic drug thalidomide.

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.

Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene.

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.

CDK5 and ABL1 enzyme substrate 1 is a protein that in humans is encoded by the CABLES1 gene.

WNT1-inducible-signaling pathway protein 3 is a matricellular protein that in humans is encoded by the WISP3 gene.

Cyclin-dependent kinase 2-associated protein 1 is an enzyme that in humans is encoded by the CDK2AP1 gene.

Dual specificity protein phosphatase 23, also known as low molecular mass dual specificity phosphatase 3 (LDP-3), is an enzyme that in humans is encoded by the DUSP23 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151893 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033417 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CDK2 associated cullin domain 1" . Retrieved 2018-01-05.

Kong Y, Nan K, Yin Y (2009). "Identification and characterization of CAC1 as a novel CDK2-associated cullin". Cell Cycle. 8 (21): 3552–61. doi: 10.4161/cc.8.21.9955 . PMID 19829063.
Kong Y, Bai PS, Sun H, Nan KJ (2012). "Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients". J. Mol. Neurosci. 47 (2): 207–18. doi:10.1007/s12031-012-9717-5. PMID 22415352. S2CID 14719772.
Kong Y, Bai PS, Sun H, Nan KJ, Chen NZ, Qi XG (2012). "The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer". Int. J. Biochem. Cell Biol. 44 (12): 2321–32. doi:10.1016/j.biocel.2012.08.006. PMID 22903020.
Moon M, Um SJ, Kim EJ (2012). "CAC1 negatively regulates RARα activity through cooperation with HDAC". Biochem. Biophys. Res. Commun. 427 (1): 41–6. doi:10.1016/j.bbrc.2012.08.142. PMID 22982681.
Kim J, Park UH, Moon M, Um SJ, Kim EJ (2013). "Negative regulation of ERα by a novel protein CAC1 through association with histone demethylase LSD1". FEBS Lett. 587 (1): 17–22. doi: 10.1016/j.febslet.2012.10.054 . PMID 23178685. S2CID 207659623.
Zheng Q, Zhao LY, Kong Y, Nan KJ, Yao Y, Liao ZJ (2013). "CDK-associated Cullin 1 can promote cell proliferation and inhibit cisplatin-induced apoptosis in the AGS gastric cancer cell line". World J Surg Oncol. 11: 5. doi: 10.1186/1477-7819-11-5 . PMC 3585504 . PMID 23311997.
Chen TJ, Gao F, Yang T, Thakur A, Ren H, Li Y, Zhang S, Wang T, Chen MW (2013). "CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells". Biochem. Biophys. Res. Commun. 437 (1): 108–13. doi:10.1016/j.bbrc.2013.06.048. PMID 23806693.
Kong Y, Ma LQ, Bai PS, Da R, Sun H, Qi XG, Ma JQ, Zhao RM, Chen NZ, Nan KJ (2013). "Helicobacter pylori promotes invasion and metastasis of gastric cancer cells through activation of AP-1 and up-regulation of CACUL1". Int. J. Biochem. Cell Biol. 45 (11): 2666–78. doi:10.1016/j.biocel.2013.08.015. PMID 24004834.
Ma HL, Wen XP, Zhang XZ, Wang XL, Zhao DL, Che SM, Dang CX (2015). "miR-106a* inhibits the proliferation of esophageal carcinoma cells by targeting CDK2-associated Cullin 1 (CACUL1)". Cell. Mol. Biol. (Noisy-le-grand). 61 (4): 56–62. PMID 26314198.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151893 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033417 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CDK2 associated cullin domain 1" . Retrieved 2018-01-05.

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CACUL1

Related Research Articles

References

Further reading