CARD10

CARD10
Identifiers
Aliases	CARD10 , BIMP1, CARMA3, caspase recruitment domain family member 10, IMD89
External IDs	OMIM: 607209 MGI: 2146012 HomoloGene: 8728 GeneCards: CARD10
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,519,542 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,687,242 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; jejunal mucosa; ; pancreatic ductal cell; ; sural nerve; ; duodenum; ; glomerulus; ; metanephric glomerulus; ; kidney tubule; ; right lobe of liver; ; visceral pleura;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; ventral tegmental area; ; motor neuron; ; pontine nuclei; ; sciatic nerve; ; renal corpuscle; ; kidney; ; utricle; ; right lung; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor complex adaptor activity ; protein binding ; CARD domain binding ;
Cellular component	cytoplasm ; CBM complex ;
Biological process	regulation of apoptotic process ; activation of NF-kappaB-inducing kinase activity ; negative regulation of cell migration involved in sprouting angiogenesis ; positive regulation of protein localization to nucleus ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	29775
	105844
	ENSG00000100065
	ENSMUSG00000033170
	Q9BWT7
	P58660
	NM_014550
	NM_130859
	NP_055365
	NP_570929
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated February 02, 2023

Caspase recruitment domain-containing protein 10 is a protein in the CARD-CC protein family that in humans is encoded by the CARD10 gene.^[5]^[6]^[7]

Function

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in signaling through highly specific protein-protein homophilic interactions. CARDs induce nuclear factor kappa-B (NF-κB; MIM 164011) activity through the IKK (e.g., IKBKB; MIM 603258) complex. CARD9 (MIM 607212), CARD10, CARD11 (MIM 607210), and CARD14 (MIM 607211) interact with BCL10 (MIM 603517) and are involved in NF-κB signaling complexes. Except for CARD9, these CARD proteins are members of the membrane-associated guanylate kinase (MAGUK) family.[supplied by OMIM]^[7]

Interactions

CARD10 has been shown to interact with BCL10.^[8]

Related Research Articles

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For the membrane coated vesicle used in transport, see here.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100065 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033170 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi: 10.1074/jbc.M102488200 . PMID 11259443.
↑ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi: 10.1016/S0014-5793(01)02414-0 . PMID 11356195.
1 2 "Entrez Gene: CARD10 caspase recruitment domain family, member 10".
↑ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi: 10.1074/jbc.M102488200 . PMID 11259443.

External links

Human CARD10 genome location and CARD10 gene details page in the UCSC Genome Browser .