CBR3

CBR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HRB
Identifiers
Aliases	CBR3 , HEL-S-25, SDR21C2, hcarbonyl reductase 3
External IDs	OMIM: 603608; MGI: 1309992; HomoloGene: 20332; GeneCards: CBR3; OMA:CBR3 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.12 Start 36,135,079 bp [1] End 36,146,562 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 C4|16 54.58 cM Start 93,480,103 bp [2] End 93,487,878 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium tendon of biceps brachii olfactory zone of nasal mucosa parotid gland cartilage tissue minor salivary glands vulva oral cavity mucosa of pharynx Achilles tendon Top expressed in epithelium of stomach pyloric antrum mucous cell of stomach cervix esophagus stroma of bone marrow skin of external ear ankle joint lip dorsal striatum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity NADPH binding carbonyl reductase (NADPH) activity 3-keto sterol reductase activity protein binding Cellular component nucleoplasm extracellular space cytoplasm cytosol Biological process phylloquinone catabolic process cognition xenobiotic metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 874 109857 Ensembl ENSG00000159231 ENSMUSG00000022947 UniProt O75828 Q8K354 RefSeq (mRNA) NM_001236 NM_173047 RefSeq (protein) NP_001227 NP_766635 Location (UCSC) Chr 21: 36.14 – 36.15 Mb Chr 16: 93.48 – 93.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene. ^{[5] [6] [7]}

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000159231 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022947 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Watanabe K, Sugawara C, Ono A, Fukuzumi Y, Itakura S, Yamazaki M, Tashiro H, Osoegawa K, Soeda E, Nomura T (May 1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics. 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID   9740676.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
7. "Entrez Gene: CBR3 carbonyl reductase 3".

External links

• Human CBR3 genome location and CBR3 gene details page in the UCSC Genome Browser .

Further reading

• Wermuth B, Mäder-Heinemann G, Ernst E (1995). "Cloning and expression of carbonyl reductase from rat testis". Eur. J. Biochem. 228 (2): 473–9. doi:10.1111/j.1432-1033.1995.tb20286.x (inactive 21 October 2025). PMID   7705364.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID   9503011.
• Ismail E, Al-Mulla F, Tsuchida S, et al. (2000). "Carbonyl reductase: a novel metastasis-modulating function". Cancer Res. 60 (5): 1173–6. PMID   10728668.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Umemoto M, Yokoyama Y, Sato S, et al. (2001). "Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer". Br. J. Cancer. 85 (7): 1032–6. doi:10.1038/sj.bjc.6692034. PMC   2375107 . PMID   11592776.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lakhman SS, Ghosh D, Blanco JG (2005). "Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)". Drug Metab. Dispos. 33 (2): 254–7. doi:10.1124/dmd.104.002006. PMID   15537833. S2CID   18027092.