CBR3

CBR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HRB
Identifiers
Aliases	CBR3 , HEL-S-25, SDR21C2, hcarbonyl reductase 3
External IDs	OMIM: 603608 MGI: 1309992 HomoloGene: 20332 GeneCards: CBR3
Gene location (Human)
Chr.	Chromosome 21 (human)
End	36,146,562 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	93,487,878 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; minor salivary glands; ; vulva; ; oral cavity; ; Achilles tendon; ; human penis; ; synovial membrane; ; synovial joint; ; gastric mucosa; ; hair follicle;
	Top expressed in
	epithelium of stomach; ; pyloric antrum; ; mucous cell of stomach; ; cervix; ; esophagus; ; ankle joint; ; lip; ; condyle; ; olfactory tubercle; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity ; NADPH binding ; carbonyl reductase (NADPH) activity ; 3-keto sterol reductase activity ; protein binding ;
Cellular component	nucleoplasm ; extracellular space ; cytoplasm ; cytosol ;
Biological process	phylloquinone catabolic process ; cognition ; xenobiotic metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	874
	109857
	ENSG00000159231
	ENSMUSG00000022947
	O75828
	Q8K354
	NM_001236
	NM_173047
	NP_001227
	NP_766635
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 26, 2024

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene.^[5]^[6]^[7]

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159231 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022947 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Watanabe K, Sugawara C, Ono A, Fukuzumi Y, Itakura S, Yamazaki M, Tashiro H, Osoegawa K, Soeda E, Nomura T (May 1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics. 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.
1 2 "Entrez Gene: CBR3 carbonyl reductase 3".

External links

Human CBR3 genome location and CBR3 gene details page in the UCSC Genome Browser .

Wermuth B, Mäder-Heinemann G, Ernst E (1995). "Cloning and expression of carbonyl reductase from rat testis". Eur. J. Biochem. 228 (2): 473–9. doi:10.1111/j.1432-1033.1995.tb20286.x. PMID 7705364.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
Ismail E, Al-Mulla F, Tsuchida S, et al. (2000). "Carbonyl reductase: a novel metastasis-modulating function". Cancer Res. 60 (5): 1173–6. PMID 10728668.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID 10830953.
Umemoto M, Yokoyama Y, Sato S, et al. (2001). "Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer". Br. J. Cancer. 85 (7): 1032–6. doi:10.1038/sj.bjc.6692034. PMC 2375107 . PMID 11592776.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Lakhman SS, Ghosh D, Blanco JG (2005). "Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)". Drug Metab. Dispos. 33 (2): 254–7. doi:10.1124/dmd.104.002006. PMID 15537833. S2CID 18027092.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000159231 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022947 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9740676-5] Watanabe K, Sugawara C, Ono A, Fukuzumi Y, Itakura S, Yamazaki M, Tashiro H, Osoegawa K, Soeda E, Nomura T (May 1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics. 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676.

[pmid19027726-6] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.

[entrez-7] 1 2 "Entrez Gene: CBR3 carbonyl reductase 3".

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CBR3

Contents

Related Research Articles

References

External links

Further reading