CBY1

CBY1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WRQ
Identifiers
Aliases	CBY1 , C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1, chibby homolog 1 (Drosophila), chibby family member 1, beta catenin antagonist, Chibby1
External IDs	OMIM: 607757 MGI: 1920989 HomoloGene: 12514 GeneCards: CBY1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,673,854 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,667,660 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• beta-catenin binding ; • GO:0001948 protein binding ; • identical protein binding ; • protein homodimerization activity ;
Cellular component	• cytosol ; • trans-Golgi network ; • Golgi apparatus ; • nuclear speck ; • nucleus ; • nucleoplasm ; • cytoplasm ; • centriole ; • cytoskeleton ; • cell projection ; • ciliary basal body ;
Biological process	• protein localization ; • cardiac muscle cell differentiation ; • negative regulation of Wnt signaling pathway ; • cell differentiation ; • negative regulation of transcription, DNA-templated ; • fat cell differentiation ; • cell projection organization ; • protein homotetramerization ; • cilium assembly ; • ciliary transition zone assembly ;
	Sources:Amigo / QuickGO
Orthologs
	25776
	73739
	ENSG00000100211
	ENSMUSG00000022428
	Q9Y3M2
	Q9D1C2
	NM_015373 ; NM_001002880
	NM_028634
	NP_001002880 ; NP_056188
	NP_082910
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 07, 2021

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.^[5]^[6]^[7]

Function

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.^[7] CBY1 has also been shown to be important for ciliogenesis and is found at the transition zone of the cilium.^[8]

Interactions

CBY1 has been shown to interact with Beta-catenin.^[9] CBY1 has also been shown to interact with CEP164, FAM92A1, and RAB8.^[8]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100211 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022428 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi: 10.1038/990031 . PMID 10591208.
↑ Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem. 279 (33): 35009–16. doi: 10.1074/jbc.M314206200 . PMID 15194699.
1 2 "Entrez Gene: CBY1 chibby homolog 1 (Drosophila)".
1 2 Li FQ, Chen X, Fisher C, Siller SS, Zelikman K, Kuriyama R, Takemaru KI (November 2016). "BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis". Molecular and Cellular Biology. 36 (21): 2668–2680. doi:10.1128/MCB.00160-16. PMC 5064215 . PMID 27528616.
↑ Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature . 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206.

External links

Human CBY1 genome location and CBY1 gene details page in the UCSC Genome Browser .

Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086 . PMID 11337467.
Collins JE, Goward ME, Cole CG, Smink LJ, Huckle EJ, Knowles S, Bye JM, Beare DM, Dunham I (2003). "Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954 . PMID 12529303.
Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature. 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206.
Gad S, Teboul D, Lièvre A, Goasguen N, Berger A, Beaune P, Laurent-Puig P (2004). "Is the gene encoding Chibby implicated as a tumour suppressor in colorectal cancer ?". BMC Cancer. 4: 31. doi:10.1186/1471-2407-4-31. PMC 471554 . PMID 15245581.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604 . PMID 15461802.
Schuierer MM, Graf E, Takemaru K, Dietmaier W, Bosserhoff AK (2006). "Reduced expression of beta-catenin inhibitor Chibby in colon carcinoma cell lines". World J. Gastroenterol. 12 (10): 1529–35. PMID 16570344.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569.
Li FQ, Singh AM, Mofunanya A, Love D, Terada N, Moon RT, Takemaru K (2007). "Chibby Promotes Adipocyte Differentiation through Inhibition of β-Catenin Signaling". Mol. Cell. Biol. 27 (12): 4347–54. doi:10.1128/MCB.01640-06. PMC 1900052 . PMID 17403895.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100211 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022428 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi: 10.1038/990031 . PMID 10591208.

[pmid15194699-6] Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem. 279 (33): 35009–16. doi: 10.1074/jbc.M314206200 . PMID 15194699.

[entrez-7] 1 2 "Entrez Gene: CBY1 chibby homolog 1 (Drosophila)".

[pmid27528616-8] 1 2 Li FQ, Chen X, Fisher C, Siller SS, Zelikman K, Kuriyama R, Takemaru KI (November 2016). "BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis". Molecular and Cellular Biology. 36 (21): 2668–2680. doi:10.1128/MCB.00160-16. PMC 5064215 . PMID 27528616.

[pmid12712206-9] Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature . 422 (6934): 905–9. doi:10.1038/nature01570. PMID 12712206.

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