CCDC80

CCDC80
Identifiers
Aliases	CCDC80 , DRO1, SSG1, URB, okuribin, coiled-coil domain containing 80, CL2, LINC01279
External IDs	OMIM: 608298; MGI: 1915146; HomoloGene: 12206; GeneCards: CCDC80; OMA:CCDC80 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.2 Start 112,596,797 bp [1] End 112,649,530 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B5 Start 44,913,765 bp [2] End 44,948,440 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura tendon of biceps brachii smooth muscle tissue skin of arm gallbladder skin of hip vena cava saphenous vein stromal cell of endometrium tibia Top expressed in calvaria stroma of bone marrow white adipose tissue ankle skin of external ear body of femur semi-lunar valve efferent ductule aortic valve umbilical cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fibronectin binding glycosaminoglycan binding heparin binding Cellular component extracellular region basement membrane interstitial matrix extracellular matrix Biological process extracellular matrix organization positive regulation of cell-substrate adhesion response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 151887 67896 Ensembl ENSG00000091986 ENSMUSG00000022665 UniProt Q76M96 Q8R2G6 RefSeq (mRNA) NM_199512 NM_199511 NM_178274 NM_026439 RefSeq (protein) NP_955805 NP_955806 NP_080715 Location (UCSC) Chr 3: 112.6 – 112.65 Mb Chr 16: 44.91 – 44.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Coiled-coil domain-containing protein 80 is a protein that in humans is encoded by the CCDC80 gene. ^{[5] [6] [7]} Bioinformatics analysis suggests the CCDC80 protein is a peroxiredoxin. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000091986 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022665 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bonaldo MF, Lennon G, Soares MB (May 1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
6. Liu Y, Monticone M, Tonachini L, Mastrogiacomo M, Marigo V, Cancedda R, Castagnola P (Aug 2004). "URB expression in human bone marrow stromal cells and during mouse development". Biochem Biophys Res Commun. 322 (2): 497–507. doi:10.1016/j.bbrc.2004.07.161. hdl: 11380/455523 . PMID   15325258.
7. "Entrez Gene: CCDC80 coiled-coil domain containing 80".
8. Pawłowski K, Muszewska A, Lenart A, et al. (2010). "A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins". BMC Genomics. 11: 590. doi: 10.1186/1471-2164-11-590 . PMC   3091736 . PMID   20964819.

External links

• Human CCDC80 genome location and CCDC80 gene details page in the UCSC Genome Browser .

Further reading

• Okada T, Nishizawa H, Kurata A, et al. (2008). "URB is abundantly expressed in adipose tissue and dysregulated in obesity". Biochem. Biophys. Res. Commun. 367 (2): 370–6. doi:10.1016/j.bbrc.2007.12.164. PMID   18178152.
• Cha SY, Sung YK, Im S, et al. (2005). "URB expression in human dermal papilla cells". J. Dermatol. Sci. 39 (2): 128–30. doi:10.1016/j.jdermsci.2005.05.005. PMID   15998583.
• Bommer GT, Jäger C, Dürr EM, et al. (2005). "DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells". J. Biol. Chem. 280 (9): 7962–75. doi: 10.1074/jbc.M412593200 . PMID   15563452.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Aoki K, Sun YJ, Aoki S, et al. (2002). "Cloning, expression, and mapping of a gene that is upregulated in adipose tissue of mice deficient in bombesin receptor subtype-3". Biochem. Biophys. Res. Commun. 290 (4): 1282–8. doi:10.1006/bbrc.2002.6337. PMID   11812002.