CCNB1IP1

CCNB1IP1
Identifiers
Aliases	CCNB1IP1 , C14orf18, HEI10, cyclin B1 interacting protein 1
External IDs	OMIM: 608249; MGI: 2685134; HomoloGene: 18819; GeneCards: CCNB1IP1; OMA:CCNB1IP1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q11.2 Start 20,311,368 bp [1] End 20,333,312 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C1 Start 51,026,705 bp [2] End 51,045,189 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary ganglionic eminence right ovary gastric mucosa cartilage tissue ventricular zone body of uterus apex of heart right auricle of heart left ventricle Top expressed in epiblast fetal liver hematopoietic progenitor cell embryo morula spermatocyte primitive streak embryo blastocyst otic placode primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding ubiquitin protein ligase activity transferase activity Cellular component condensed nuclear chromosome synaptonemal complex nucleus chromosome Biological process reciprocal meiotic recombination chiasma assembly meiosis blastocyst formation protein ubiquitination spermatid development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57820 239083 Ensembl ENSG00000100814 ENSMUSG00000071470 UniProt Q9NPC3 D3Z3K2 RefSeq (mRNA) NM_182852 NM_021178 NM_182849 NM_182851 NM_001111119 RefSeq (protein) NP_067001 NP_878269 NP_878272 NP_001104589 Location (UCSC) Chr 14: 20.31 – 20.33 Mb Chr 14: 51.03 – 51.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene. ^{[5] [6]}

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM] ^[6] It is considered a housekeeping gene.

During meiosis, crossing over between homologous chromosomes (homologs) facilitates accurate chromosome segregation. ^[7] In mammals, the ring-domain protein CCNB1IP1, also known as HEI10, promotes crossing over between each pair of homologs during meiosis. ^[7] Studies in the mouse showed that this pro-crossover ring-domain protein facilitates the homologous recombination and DNA repair processes that produce crossovers. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000100814 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071470 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Toby GG, Gherraby W, Coleman TR, Golemis EA (Mar 2003). "A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels". Mol Cell Biol. 23 (6): 2109–2122. doi:10.1128/MCB.23.6.2109-2122.2003. PMC   149478 . PMID   12612082.
6. "Entrez Gene: CCNB1IP1 cyclin B1 interacting protein 1".
7. Ito M, Yun Y, Kulkarni DS, Lee S, Sandhu S, Nuñez B, Hu L, Lee K, Lim N, Hirota RM, Prendergast R, Huang C, Huang I, Hunter N (January 2025). "Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis". Proc Natl Acad Sci U S A. 122 (2): e2412961121. doi:10.1073/pnas.2412961121. PMC   11745341 . PMID   39761402.

External links

• Human CCNB1IP1 genome location and CCNB1IP1 gene details page in the UCSC Genome Browser .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Grönholm M, Muranen T, Toby GG, et al. (2006). "A functional association between merlin and HEI10, a cell cycle regulator". Oncogene. 25 (32): 4389–4398. doi: 10.1038/sj.onc.1209475 . PMID   16532029.