CCT3

CCT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GML, 1GN1
Identifiers
Aliases	CCT3 , CCT-gamma, CCTG, PIG48, TCP-1-gamma, TRIC5, chaperonin containing TCP1 subunit 3
External IDs	OMIM: 600114; MGI: 104708; HomoloGene: 4373; GeneCards: CCT3; OMA:CCT3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,367,873 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,229,074 bp
RNA expression pattern
	Top expressed in
	gonad; ; embryo; ; islet of Langerhans; ; ventricular zone; ; ganglionic eminence; ; right adrenal gland; ; smooth muscle tissue; ; right testis; ; left testis; ; right adrenal cortex;
	Top expressed in
	primitive streak; ; otic placode; ; Paneth cell; ; maxillary prominence; ; saccule; ; mandibular prominence; ; otic vesicle; ; condyle; ; somite; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; protein folding chaperone activity ; protein binding ; ATP binding ; unfolded protein binding ; RNA binding ;
Cellular component	cell body ; myelin sheath ; plasma membrane ; zona pellucida receptor complex ; chaperonin-containing T-complex ; microtubule ; cytoskeleton ; extracellular exosome ; cytoplasm ; cytosol ;
Biological process	positive regulation of protein localization to Cajal body ; pore complex assembly ; protein stabilization ; positive regulation of telomere maintenance via telomerase ; toxin transport ; protein folding ; positive regulation of telomerase RNA localization to Cajal body ; binding of sperm to zona pellucida ; 'de novo' protein folding ; chaperone-mediated protein folding ;
	Sources:Amigo / QuickGO
Orthologs
	7203
	12462
	ENSG00000163468
	ENSMUSG00000001416
	P49368 ; Q5SZW8
	P80318
	NM_001008800 ; NM_001008883 ; NM_005998
	NM_009836
	NP_001008800 ; NP_005989
	NP_033966
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 03, 2024

T-complex protein 1 subunit gamma is a protein that in humans is encoded by the CCT3 gene.^[5]^[6]

Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

Interactions

CCT3 has been shown to interact with PPP4C.^[7]^[8]

Related Research Articles

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that is encoded by the PPP2CA gene.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.

In humans, the gene T-complex 1, a.k.a. TCP1, encodes the protein TCP-1, a.k.a. T-complex protein 1 subunit alpha.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene. Mutations in PPP2R5D cause Jordan's syndrome.

<span class="mw-page-title-main">CCT5 (gene)</span> Protein-coding gene in the species Homo sapiens

T-complex protein 1 subunit epsilon is a protein that in humans is encoded by the CCT5 gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.

T-complex protein 1 subunit theta is a protein that in humans is encoded by the CCT8 gene. The CCT8 protein is a component of the TRiC complex.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.

T-complex protein 1 subunit eta is a protein that in humans is encoded by the CCT7 gene.

T-complex protein 1 subunit delta is a protein that in humans is encoded by the CCT4 gene. The CCT4 protein is a component of the TRiC complex.

T-complex protein 1 subunit zeta is a protein that in humans is encoded by the CCT6A gene.

T-complex protein 1 subunit beta is a protein that in humans is encoded by the CCT2 gene.

Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.

Serine/threonine-protein phosphatase 4 regulatory subunit 3B is an enzyme that in humans is encoded by the SMEK2 gene.

Serine/threonine-protein phosphatase 4 regulatory subunit 1 is an enzyme that in humans is encoded by the PPP4R1 gene.

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163468 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001416 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Joly EC, Sévigny G, Todorov IT, Bibor-Hardy V (Mar 1994). "cDNA encoding a novel TCP1-related protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1217 (2): 224–6. doi:10.1016/0167-4781(94)90041-8. PMID 8110840.
1 2 "Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)".
↑ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi: 10.1074/jbc.M803443200 . PMC 2662017 . PMID 18715871.
↑ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi: 10.1074/mcp.M500231-MCP200 . PMID 16085932.

External links

Human CCT3 genome location and CCT3 gene details page in the UCSC Genome Browser .

Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. Bibcode:1994CBio....4...89K. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530. S2CID 31300131.
Sévigny G, Joly EC, Bibor-Hardy V, Lemieux N (Aug 1994). "Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization". Genomics. 22 (3): 634–6. doi:10.1006/geno.1994.1438. PMID 8001976.
Walkley NA, Demaine AG, Malik AN (Jan 1996). "Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma". The Biochemical Journal. 313 (Pt 2): 381–9. doi:10.1042/bj3130381. PMC 1216920 . PMID 8573069.
Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J (Dec 1999). "Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC". Molecular Cell. 4 (6): 1051–61. doi: 10.1016/S1097-2765(00)80233-6 . PMID 10635329.
Wong N, Chan A, Lee SW, Lam E, To KF, Lai PB, Li XN, Liew CT, Johnson PJ (Mar 2003). "Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression". Journal of Hepatology. 38 (3): 298–306. doi:10.1016/S0168-8278(02)00412-9. PMID 12586295.
Yuryev A, Wennogle LP (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (Oct 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (Dec 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry. 278 (51): 51901–10. doi: 10.1074/jbc.M309655200 . PMID 14532270.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163468 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001416 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8110840-5] Joly EC, Sévigny G, Todorov IT, Bibor-Hardy V (Mar 1994). "cDNA encoding a novel TCP1-related protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1217 (2): 224–6. doi:10.1016/0167-4781(94)90041-8. PMID 8110840.

[entrez-6] 1 2 "Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)".

[pmid18715871-7] Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi: 10.1074/jbc.M803443200 . PMC 2662017 . PMID 18715871.

[pmid16085932-8] Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi: 10.1074/mcp.M500231-MCP200 . PMID 16085932.

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