CCT4

Last updated

CCT4
Identifiers
Aliases CCT4 , CCT-DELTA, Cctd, SRB, chaperonin containing TCP1 subunit 4
External IDs OMIM: 605142; MGI: 104689; HomoloGene: 4695; GeneCards: CCT4; OMA:CCT4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006430
NM_001256721

NM_009837

RefSeq (protein)

NP_001243650
NP_006421

NP_033967

Location (UCSC) Chr 2: 61.87 – 61.89 Mb Chr 11: 22.94 – 22.95 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

T-complex protein 1 subunit delta is a protein that in humans is encoded by the CCT4 gene. [5] [6] The CCT4 protein is a component of the TRiC complex.

Contents

Interactions

CCT4 has been shown to interact with PPP4C. [7] [8]

Related Research Articles

<span class="mw-page-title-main">Chaperonin</span> InterPro Family

HSP60, also known as chaperonins (Cpn), is a family of heat shock proteins originally sorted by their 60kDa molecular mass. They prevent misfolding of proteins during stressful situations such as high heat, by assisting protein folding. HSP60 belong to a large class of molecules that assist protein folding, called molecular chaperones.

<span class="mw-page-title-main">EIF3S6</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit E (eIF3e) is a protein that in humans is encoded by the EIF3E gene.

<span class="mw-page-title-main">T-complex 1</span> Protein-coding gene in the species Homo sapiens

In humans, the gene T-complex 1, a.k.a. TCP1, encodes the protein TCP-1, a.k.a. T-complex protein 1 subunit alpha.

<span class="mw-page-title-main">EIF3A</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

<span class="mw-page-title-main">EIF2S2</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

<span class="mw-page-title-main">CCT5 (gene)</span> Protein-coding gene in the species Homo sapiens

T-complex protein 1 subunit epsilon is a protein that in humans is encoded by the CCT5 gene.

<span class="mw-page-title-main">PFDN1</span> Protein-coding gene in the species Homo sapiens

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.

<span class="mw-page-title-main">EIF3H</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene.

<span class="mw-page-title-main">CCT8</span> Protein-coding gene in the species Homo sapiens

T-complex protein 1 subunit theta is a protein that in humans is encoded by the CCT8 gene. The CCT8 protein is a component of the TRiC complex.

<span class="mw-page-title-main">PCYT1B</span> Protein-coding gene in the species Homo sapiens

Choline-phosphate cytidylyltransferase B is an enzyme that in humans is encoded by the PCYT1B gene.

<span class="mw-page-title-main">CCT7</span> Protein-coding gene in the species Homo sapiens

T-complex protein 1 subunit eta is a protein that in humans is encoded by the CCT7 gene.

<span class="mw-page-title-main">EIF3F</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a protein that in humans is encoded by the EIF3F gene.

<span class="mw-page-title-main">CCT6A</span> Protein-coding gene in the species Homo sapiens

T-complex protein 1 subunit zeta is a protein that in humans is encoded by the CCT6A gene.

<span class="mw-page-title-main">CCT2 (gene)</span> Protein-coding gene in humans

T-complex protein 1 subunit beta is a protein that in humans is encoded by the CCT2 gene.

<span class="mw-page-title-main">EIF3J</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 3 subunit J (eIF3j) is a protein that in humans is encoded by the EIF3J gene.

<span class="mw-page-title-main">CCT3</span> Protein-coding gene in the species Homo sapiens

T-complex protein 1 subunit gamma is a protein that in humans is encoded by the CCT3 gene.

<span class="mw-page-title-main">MRPS7</span> Protein-coding gene in the species Homo sapiens

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.

<span class="mw-page-title-main">PFDN4</span> Protein-coding gene in the species Homo sapiens

Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene.

<span class="mw-page-title-main">CCT6B</span> Protein-coding gene in the species Homo sapiens

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.

<span class="mw-page-title-main">TRiC (complex)</span> Multiprotein complex used in cellular proteostasis

T-complex protein Ring Complex (TRiC), otherwise known as Chaperonin Containing TCP-1 (CCT), is a multiprotein complex and the chaperonin of eukaryotic cells. Like the bacterial GroEL, the TRiC complex aids in the folding of ~10% of the proteome, and actin and tubulin are some of its best known substrates. TRiC is an example of a biological machine that folds substrates within the central cavity of its barrel-like assembly using the energy from ATP hydrolysis.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115484 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000007739 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC   109339 . PMID   9819444.
  6. "Entrez Gene: CCT4 chaperonin containing TCP1, subunit 4 (delta)".
  7. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi: 10.1074/jbc.M803443200 . PMC   2662017 . PMID   18715871.
  8. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi: 10.1074/mcp.M500231-MCP200 . PMID   16085932. S2CID   7531012.

Further reading