CCT6B

CCT6B
Identifiers
Aliases	CCT6B , CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303, chaperonin containing TCP1 subunit 6B
External IDs	OMIM: 610730; MGI: 1329013; HomoloGene: 55978; GeneCards: CCT6B; OMA:CCT6B - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q12 Start 34,927,859 bp [1] End 34,981,078 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 C Start 82,610,076 bp [2] End 82,655,147 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis testicle gonad olfactory zone of nasal mucosa Achilles tendon gastrocnemius muscle palpebral conjunctiva gastric mucosa Top expressed in spermatid spermatocyte seminiferous tubule blastocyst embryo Ileal epithelium embryo morula morula right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATP binding protein folding chaperone activity unfolded protein binding Cellular component cytoplasm cytosol chaperonin-containing T-complex Biological process toxin transport protein folding chaperone-mediated protein complex assembly spermatogenesis protein transport 'de novo' protein folding chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10693 12467 Ensembl ENSG00000132141 ENSMUSG00000020698 UniProt Q92526 Q61390 RefSeq (mRNA) NM_001193529 NM_001193530 NM_006584 NM_001291242 NM_009839 RefSeq (protein) NP_001180458 NP_001180459 NP_006575 NP_001278171 NP_033969 Location (UCSC) Chr 17: 34.93 – 34.98 Mb Chr 11: 82.61 – 82.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene. ^{[5] [6] [7]}

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000132141 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020698 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ozaki K, Kuroki T, Hayashi S, Nakamura Y (Jan 1997). "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method". Genomics. 36 (2): 316–9. doi:10.1006/geno.1996.0467. PMID   8812458.
6. Kubota H, Hynes GM, Kerr SM, Willison KR (Feb 1997). "Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1" (PDF). FEBS Lett. 402 (1): 53–6. doi: 10.1016/S0014-5793(96)01501-3 . PMID   9013858. S2CID   1972107.
7. "Entrez Gene: CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)".

External links

• Human CCT6B genome location and CCT6B gene details page in the UCSC Genome Browser .

Further reading

• Stirling PC, Cuéllar J, Alfaro GA, et al. (2006). "PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates". J. Biol. Chem. 281 (11): 7012–21. doi: 10.1074/jbc.M513235200 . PMID   16415341.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.